source_paper
string | source_section
string | premise
string | target_doi
string | target_paper
string |
|---|---|---|---|---|
PMC9728410
|
Current Status of COVID-19 Vaccine Development
|
DNA vaccine candidates targeting SARS-CoV N protein as an immunogen can generate N-specific humoral and cellular immune response [93].
|
10.1128/JVI.78.9.4638-4645.2004
|
PMC387705
|
PMC9728410
|
Current Status of COVID-19 Vaccine Development
|
Another major hurdle for vaccine development is higher mutation rates of RNA viruses compared to DNA viruses, resulting in higher genetic diversity [94].
|
10.1371/journal.pbio.3000003
|
PMC6107253
|
PMC9728410
|
Current Status of COVID-19 Vaccine Development
|
Moreover, the RBD of the S protein is the most variable region in the coronavirus genome [95].
|
10.1038/s41586-020-2012-7
|
PMC7095418
|
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