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00F7E42707CA13179ACD7757F22E71D26FDD460D_p13
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00F7E42707CA13179ACD7757F22E71D26FDD460D
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sec[0]/sec[4]/p[0]
|
Les hommes âgés atteints de cancer de la prostate sont-ils sous-traités ?
| 4.191406
| -0.95197
|
biomedical
|
Study
|
[
0.9970703125,
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[
0.99658203125,
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Trois études récentes ont tenté de répondre à cette question. Alibahi et al. 33 ont extrait un groupe randomisé stratifié de 347 sujets, à partir de la cohorte des patients présentant un cancer de la prostate nouvellement diagnostiqué du Ontario Cancer Registry, entre 1995 et 1996. Ils ont montré qu'un patient de moins de 60 ans est plus susceptible de subir une prostatectomie radicale qu'une radiothérapie ou que de ne pas être traité. Les hommes de 60 à 69 ans sont plus susceptibles de recevoir une radiothérapie qu'une prostatectomie radicale, en particulier après 65 ans. Les hommes de 70 à 79 ans sont plus susceptibles de ne recevoir aucun traitement, et presque tous les sujets appartenant au groupe le plus âgé (plus de 80 ans) ne recevaient aucun traitement. L'âge du patient, le score index de Charlson 34 , le stade et l'année de spécialisation de l'urologue sont associés à une probabilité décroissante de recevoir un traitement curateur. Les sujets ayant une espérance de vie élevée reçoivent en général un traitement potentiellement curateur plus souvent que ceux dont l'espérance de vie est faible. De plus, de nombreux sujets ayant une espérance de vie restante limitée reçoivent un traitement potentiellement curateur. Mais, malgré une espérance de vie restante semblable, les hommes âgés sont beaucoup moins susceptibles de recevoir un traitement curateur que les hommes jeunes. Parmi les sujets ayant une espérance de vie supérieure à 10 ans, 72,7 % des hommes de moins de 60 ans et 67,5 % des hommes de 60 à 69 ans reçoivent un traitement potentiellement curateur, par rapport à seulement 40 % des hommes de 70 à 79 ans. Les différences sont encore plus marquées dans le cas de la chirurgie (65,5 %, 40 % et 0 %, respectivement). Dans cette étude, même après ajustement pour l'espérance de vie restante et pour d'autres variables prédictives, l'augmentation de l'âge était associée à une probabilité moindre de subir une prostatectomie radicale ou une radiothérapie.
|
[
"M. Waldert",
"B. Djavan",
"R. Yatani",
"I. Chigusa",
"K. Akazaki",
"G.N. Stemmermann",
"R.A. Welsh",
"P. Correa",
"F.T. Scardino",
"A. Jemal",
"T. Murray",
"A. Samuels",
"A. Ghafoor",
"E. Ward",
"M.J. Thun",
"L.M. Newcomer",
"J.L. Stanford",
"B.A. Blumenstein",
"M.K. Brawer",
"H.B. Carter",
"S. Piantadosi",
"J.T. Isaacs",
"H.I. Scher",
"J.T. Isaacs",
"M.J. Zelefsky",
"H.S. Ruchlin",
"J.M. Pellissier",
"G.W. Chodak",
"R.A. Thisted",
"G.S. Gerber",
"J.E. Johansson",
"J. Adolfsson",
"G.W. Jones",
"P.C. Albertsen",
"J.A. Hanley",
"D.F. Gleason",
"M.J. Barry",
"P.C. Albertsen",
"J.A. Hanley",
"J. Fine",
"M. Menon",
"B.G. Parulkar",
"S. Baker",
"M.D. Krahn",
"K.E. Bremner",
"J. Asaria",
"S.M. Alibhai",
"R. Nam",
"G. Tomlinson",
"J. Samet",
"W.C. Hunt",
"C. Key",
"C.G. Humble",
"J.S. Goodwin",
"G.L. Lu- Yao",
"D. McLerran",
"J. Wasson",
"J.E. Wennberg",
"R.K. Sverson",
"J.E. Montie",
"A.T. Porter",
"R.Y. Demers",
"C.E. Desch",
"L. Penberthy",
"C.J. Newschaffer",
"B.E. Hillner",
"M. Whittemore",
"D. McClish",
"J.S. Goodwin",
"W.C. Hunt",
"J.M. Samet",
"L.C. Harlan",
"A. Potosky",
"F.D. Gilliland",
"R. Hoffman",
"P.C. Albertsen",
"A.S. Hamilton",
"C.L. Bennett",
"S. Greenfield",
"H. Aronow",
"P. Ganz",
"N.J. Vogelzang",
"R.M. Elashoff",
"P.N. Post",
"P.J. Kil",
"A.J. Hendrikx",
"M.L. Janssen-Heijnen",
"M.A. Crommelin",
"J.W. Coebergh",
"Y. Yan",
"G.F. Carvalhal",
"W.J. Catalona",
"J.D. Young",
"A.H. Horan",
"M. McGehee",
"A.M. Minino",
"B.L. Smith",
"J.H. Wasson",
"C.C. Cushman",
"R.C. Bruskewitz",
"B. Littenberg",
"A.G. Mulley",
"J.E. Wennberg",
"J.E. Johansson",
"J.I. Epstein",
"P.C. Walsh",
"M. Carmichael",
"C.B. Brendler",
"P.A. Humphrey",
"D.W. Keetch",
"D.S. Smith",
"D.L. Shepherd",
"W.J. Catalona",
"M.J. Barry",
"C. Fleming",
"C.M. Coley",
"J.H. Wasson",
"M.C. Fahs",
"J.E. Oesterling",
"K.S. Ross",
"H.B. Carter",
"J.D. Pearson",
"H.A. Guess",
"H.B. Carter",
"P.K. Landis",
"E.J. Metter",
"L.A. Fleisher",
"J.D. Pearson",
"S.M. Alibhai",
"M.D. Krahn",
"M.M. Cohen",
"N.E. Fleshner",
"G.A. Tomlinson",
"G. Naglie",
"M.E. Charlson",
"P. Pompei",
"K.L. Ales",
"C.R. MacKenzie",
"K.L. Schwartz",
"S.M. Alibhai",
"G. Tomlinson",
"G. Naglie",
"M.D. Krahn",
"P. Dahm",
"A.D. Silverstein",
"A.Z. Weizer",
"A. Crisci",
"J. Vieweg",
"D.F. Paulson",
"J.A. Talcott",
"P. Rieker",
"J.A. Clark",
"K.J. Propert",
"J.C. Weeks",
"C.J. Beard",
"G.L. Lu-Yao",
"P. Albertsen",
"J. Warren",
"S.L. Yao",
"J.L. Stanford",
"Z. Feng",
"A.S. Hamilton",
"F.D. Gilliland",
"R.A. Stephenson",
"J.W. Eley",
"D.A. Corral",
"R.R. Bahnson"
] |
https://doi.org/10.1016/j.anuro.2006.09.002
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
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00F7E42707CA13179ACD7757F22E71D26FDD460D_p14
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00F7E42707CA13179ACD7757F22E71D26FDD460D
|
sec[0]/sec[4]/p[1]
|
Les hommes âgés atteints de cancer de la prostate sont-ils sous-traités ?
| 4.019531
| -0.23016
|
biomedical
|
Study
|
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Dans leur étude, Schwartz et al. 35 ont revu les décisions thérapeutiques dans une cohorte d'hommes atteints de cancer de la prostate localisé, pour déterminer si ces décisions étaient optimales et pour identifier les facteurs associés aux décisions thérapeutiques infraoptimales. L'âge, les maladies associées et le score de Gleason sont des facteurs prédictifs indépendants de traitement infraoptimal. Le groupe le plus souvent soumis à un traitement infraoptimal était celui des septuagénaires porteurs d'une tumeur moyennement ou peu différenciée et sans maladie associée ou présentant une maladie concomitante non grave. Plusieurs hommes de ce groupe étaient traités de manière insuffisante, c'est-à-dire n'étaient soumis qu'à une simple observation alors qu'un traitement potentiellement curateur aurait été préférable, provoquant des pertes en termes de résultats par rapport à ceux qui auraient pu être obtenus grâce à un traitement optimal.
|
[
"M. Waldert",
"B. Djavan",
"R. Yatani",
"I. Chigusa",
"K. Akazaki",
"G.N. Stemmermann",
"R.A. Welsh",
"P. Correa",
"F.T. Scardino",
"A. Jemal",
"T. Murray",
"A. Samuels",
"A. Ghafoor",
"E. Ward",
"M.J. Thun",
"L.M. Newcomer",
"J.L. Stanford",
"B.A. Blumenstein",
"M.K. Brawer",
"H.B. Carter",
"S. Piantadosi",
"J.T. Isaacs",
"H.I. Scher",
"J.T. Isaacs",
"M.J. Zelefsky",
"H.S. Ruchlin",
"J.M. Pellissier",
"G.W. Chodak",
"R.A. Thisted",
"G.S. Gerber",
"J.E. Johansson",
"J. Adolfsson",
"G.W. Jones",
"P.C. Albertsen",
"J.A. Hanley",
"D.F. Gleason",
"M.J. Barry",
"P.C. Albertsen",
"J.A. Hanley",
"J. Fine",
"M. Menon",
"B.G. Parulkar",
"S. Baker",
"M.D. Krahn",
"K.E. Bremner",
"J. Asaria",
"S.M. Alibhai",
"R. Nam",
"G. Tomlinson",
"J. Samet",
"W.C. Hunt",
"C. Key",
"C.G. Humble",
"J.S. Goodwin",
"G.L. Lu- Yao",
"D. McLerran",
"J. Wasson",
"J.E. Wennberg",
"R.K. Sverson",
"J.E. Montie",
"A.T. Porter",
"R.Y. Demers",
"C.E. Desch",
"L. Penberthy",
"C.J. Newschaffer",
"B.E. Hillner",
"M. Whittemore",
"D. McClish",
"J.S. Goodwin",
"W.C. Hunt",
"J.M. Samet",
"L.C. Harlan",
"A. Potosky",
"F.D. Gilliland",
"R. Hoffman",
"P.C. Albertsen",
"A.S. Hamilton",
"C.L. Bennett",
"S. Greenfield",
"H. Aronow",
"P. Ganz",
"N.J. Vogelzang",
"R.M. Elashoff",
"P.N. Post",
"P.J. Kil",
"A.J. Hendrikx",
"M.L. Janssen-Heijnen",
"M.A. Crommelin",
"J.W. Coebergh",
"Y. Yan",
"G.F. Carvalhal",
"W.J. Catalona",
"J.D. Young",
"A.H. Horan",
"M. McGehee",
"A.M. Minino",
"B.L. Smith",
"J.H. Wasson",
"C.C. Cushman",
"R.C. Bruskewitz",
"B. Littenberg",
"A.G. Mulley",
"J.E. Wennberg",
"J.E. Johansson",
"J.I. Epstein",
"P.C. Walsh",
"M. Carmichael",
"C.B. Brendler",
"P.A. Humphrey",
"D.W. Keetch",
"D.S. Smith",
"D.L. Shepherd",
"W.J. Catalona",
"M.J. Barry",
"C. Fleming",
"C.M. Coley",
"J.H. Wasson",
"M.C. Fahs",
"J.E. Oesterling",
"K.S. Ross",
"H.B. Carter",
"J.D. Pearson",
"H.A. Guess",
"H.B. Carter",
"P.K. Landis",
"E.J. Metter",
"L.A. Fleisher",
"J.D. Pearson",
"S.M. Alibhai",
"M.D. Krahn",
"M.M. Cohen",
"N.E. Fleshner",
"G.A. Tomlinson",
"G. Naglie",
"M.E. Charlson",
"P. Pompei",
"K.L. Ales",
"C.R. MacKenzie",
"K.L. Schwartz",
"S.M. Alibhai",
"G. Tomlinson",
"G. Naglie",
"M.D. Krahn",
"P. Dahm",
"A.D. Silverstein",
"A.Z. Weizer",
"A. Crisci",
"J. Vieweg",
"D.F. Paulson",
"J.A. Talcott",
"P. Rieker",
"J.A. Clark",
"K.J. Propert",
"J.C. Weeks",
"C.J. Beard",
"G.L. Lu-Yao",
"P. Albertsen",
"J. Warren",
"S.L. Yao",
"J.L. Stanford",
"Z. Feng",
"A.S. Hamilton",
"F.D. Gilliland",
"R.A. Stephenson",
"J.W. Eley",
"D.A. Corral",
"R.R. Bahnson"
] |
https://doi.org/10.1016/j.anuro.2006.09.002
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
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fr
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00F7E42707CA13179ACD7757F22E71D26FDD460D
|
sec[0]/sec[4]/p[2]
|
Les hommes âgés atteints de cancer de la prostate sont-ils sous-traités ?
| 4.128906
| -0.919165
|
biomedical
|
Study
|
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0.99365234375,
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0.004909515380859375,
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Dahm et al. 36 fournissent des estimations de probabilité de décès à long terme par cancer de la prostate et autres causes compétitives, chez 484 patients de 70 ans ou plus, soumis à chirurgie périnéale radicale pour un cancer de la prostate limité à l'organe, entre 1970 et 2000. Les hommes assignés à la prostatectomie radicale avaient un risque significativement inférieur de décès par cancer de la prostate par rapport aux patients assignés au groupe simple observation. Leurs résultats suggèrent que les cancers avec un score de Gleason de 6 ou moins à la biopsie présentent un risque biologique très faible chez les patients ayant une espérance de vie de 10 ans ou moins. Mais, même chez les patients de 70 ans ou plus, ayant un score de Gleason de 7, plus de patients mouraient de cancer de la prostate à 10 ans de suivi que d'autres causes. Chez les patients dont le cancer de la prostate est associé à un score de Gleason de 8 à 10, le risque de mourir de cancer de la prostate était de 40,2 %, et plus du double par rapport aux autres causes concomitantes. Les patients ayant un score de Gleason précis et une espérance de vie projetée d'au moins 10 ans pourraient avoir un risque semblable de mourir de cancer de la prostate par rapport aux patients plus jeunes.
|
[
"M. Waldert",
"B. Djavan",
"R. Yatani",
"I. Chigusa",
"K. Akazaki",
"G.N. Stemmermann",
"R.A. Welsh",
"P. Correa",
"F.T. Scardino",
"A. Jemal",
"T. Murray",
"A. Samuels",
"A. Ghafoor",
"E. Ward",
"M.J. Thun",
"L.M. Newcomer",
"J.L. Stanford",
"B.A. Blumenstein",
"M.K. Brawer",
"H.B. Carter",
"S. Piantadosi",
"J.T. Isaacs",
"H.I. Scher",
"J.T. Isaacs",
"M.J. Zelefsky",
"H.S. Ruchlin",
"J.M. Pellissier",
"G.W. Chodak",
"R.A. Thisted",
"G.S. Gerber",
"J.E. Johansson",
"J. Adolfsson",
"G.W. Jones",
"P.C. Albertsen",
"J.A. Hanley",
"D.F. Gleason",
"M.J. Barry",
"P.C. Albertsen",
"J.A. Hanley",
"J. Fine",
"M. Menon",
"B.G. Parulkar",
"S. Baker",
"M.D. Krahn",
"K.E. Bremner",
"J. Asaria",
"S.M. Alibhai",
"R. Nam",
"G. Tomlinson",
"J. Samet",
"W.C. Hunt",
"C. Key",
"C.G. Humble",
"J.S. Goodwin",
"G.L. Lu- Yao",
"D. McLerran",
"J. Wasson",
"J.E. Wennberg",
"R.K. Sverson",
"J.E. Montie",
"A.T. Porter",
"R.Y. Demers",
"C.E. Desch",
"L. Penberthy",
"C.J. Newschaffer",
"B.E. Hillner",
"M. Whittemore",
"D. McClish",
"J.S. Goodwin",
"W.C. Hunt",
"J.M. Samet",
"L.C. Harlan",
"A. Potosky",
"F.D. Gilliland",
"R. Hoffman",
"P.C. Albertsen",
"A.S. Hamilton",
"C.L. Bennett",
"S. Greenfield",
"H. Aronow",
"P. Ganz",
"N.J. Vogelzang",
"R.M. Elashoff",
"P.N. Post",
"P.J. Kil",
"A.J. Hendrikx",
"M.L. Janssen-Heijnen",
"M.A. Crommelin",
"J.W. Coebergh",
"Y. Yan",
"G.F. Carvalhal",
"W.J. Catalona",
"J.D. Young",
"A.H. Horan",
"M. McGehee",
"A.M. Minino",
"B.L. Smith",
"J.H. Wasson",
"C.C. Cushman",
"R.C. Bruskewitz",
"B. Littenberg",
"A.G. Mulley",
"J.E. Wennberg",
"J.E. Johansson",
"J.I. Epstein",
"P.C. Walsh",
"M. Carmichael",
"C.B. Brendler",
"P.A. Humphrey",
"D.W. Keetch",
"D.S. Smith",
"D.L. Shepherd",
"W.J. Catalona",
"M.J. Barry",
"C. Fleming",
"C.M. Coley",
"J.H. Wasson",
"M.C. Fahs",
"J.E. Oesterling",
"K.S. Ross",
"H.B. Carter",
"J.D. Pearson",
"H.A. Guess",
"H.B. Carter",
"P.K. Landis",
"E.J. Metter",
"L.A. Fleisher",
"J.D. Pearson",
"S.M. Alibhai",
"M.D. Krahn",
"M.M. Cohen",
"N.E. Fleshner",
"G.A. Tomlinson",
"G. Naglie",
"M.E. Charlson",
"P. Pompei",
"K.L. Ales",
"C.R. MacKenzie",
"K.L. Schwartz",
"S.M. Alibhai",
"G. Tomlinson",
"G. Naglie",
"M.D. Krahn",
"P. Dahm",
"A.D. Silverstein",
"A.Z. Weizer",
"A. Crisci",
"J. Vieweg",
"D.F. Paulson",
"J.A. Talcott",
"P. Rieker",
"J.A. Clark",
"K.J. Propert",
"J.C. Weeks",
"C.J. Beard",
"G.L. Lu-Yao",
"P. Albertsen",
"J. Warren",
"S.L. Yao",
"J.L. Stanford",
"Z. Feng",
"A.S. Hamilton",
"F.D. Gilliland",
"R.A. Stephenson",
"J.W. Eley",
"D.A. Corral",
"R.R. Bahnson"
] |
https://doi.org/10.1016/j.anuro.2006.09.002
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
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00F7E42707CA13179ACD7757F22E71D26FDD460D
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sec[0]/sec[4]/p[3]
|
Les hommes âgés atteints de cancer de la prostate sont-ils sous-traités ?
| 4.359375
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biomedical
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Du fait de l'impact potentiellement néfaste d'un cancer de la prostate agressif, les patients âgés en bonne santé devraient être suivis régulièrement par des dosages de PSA et subir une biopsie lorsque le PSA est élevé. Alors qu'aucune limite d'âge n'a été établie pour le dosage du PSA, il existe un consensus général sur le fait que les sujets ayant moins de 10 ans d'espérance de vie ont peu de chances de tirer bénéfice du dépistage en raison de la longue histoire naturelle du cancer de la prostate localisé non traité, et de la présence de causes concomitantes de décès 11 . Comme mentionné ci-dessus, le score de Gleason du cancer de la prostate est un puissant facteur prédictif de l'histoire naturelle de la maladie et doit être valorisé dans le processus décisionnel. Les patients ayant un cancer de la prostate peu différencié ont un risque élevé de décès par cancer de la prostate, même au-delà de 70 ans. Le traitement doit être adapté à l'individu, les cancers agressifs doivent être traités agressivement et l'âge des patients ne doit pas être considéré de façon inappropriée dans le processus décisionnel thérapeutique dans le cas d'un cancer de la prostate localisé. Mais pourquoi l'âge influence-t-il le choix thérapeutique, même chez les hommes âgés en bonne santé ? Divers facteurs pourraient l'expliquer. Les cliniciens seraient réticents à proposer un traitement agressif aux hommes âgés en raison d'un risque plus élevé d'effets secondaires à court et à long termes 37-39 . De plus, les urologues pourraient appliquer des seuils d'âge à la prostatectomie radicale. La règle des 10 ans pourrait avoir été transformée en limite d'âge à 70 ans, comme le montrent des enquêtes conduites aux États-Unis, au Royaume-Uni, au Canada et comme mis en évidence par les commentaires d'urologues reconnus 40 . L'âge du patient pourrait aussi influencer les préférences thérapeutiques. Les patients âgés pourraient être plus exposés aux risques et moins disposés à sacrifier leur qualité de vie au profit d'un prolongement de la vie. Certains sujets âgés pourraient préférer la chirurgie, même si elle n'apporte aucun bénéfice évident en termes de survie par rapport au traitement d'attente, et adhérer aux conseils de leur médecin ou désirer que leur médecin prenne la décision thérapeutique.
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Actuellement, aucun marqueur biologique du cancer de la prostate n'est disponible pour déterminer de manière certaine quels sujets peuvent être traités par la simple observation en toute sécurité. Les critères cliniques sont donc le meilleur moyen pour déterminer la présence d'une maladie de petit volume. La sélection et le suivi attentif des hommes âgés porteurs d'un cancer de petit volume pourraient fournir une alternative raisonnable au traitement de tous les cancers dépistés.
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Med Buccale Chir Buccale 2013;19:33-38 2010 © SFCO, SFMBCB, 2012 2010 DOI: 10.1051/mbcb/ 10.1051/mbcb/2012043 www.mbcb-journal.org Mise en point Traitement orthodontique dans les fentes labio-palatines au Mexique Eric Beljour1,*, Mónica Domínguez2, María del Carmen Rosas Ramírez2, Manuel Yudovich Burak2 1 Département d’Orthodontie, UNAM, et Division de Stomatologie-Orthodontie, Hôpital général Dr Manuel Gea González, Mexico, Mexique 2 Division de Stomatologie-Orthodontie, Hôpital général Dr Manuel Gea González, Mexico, Mexique Mots clés : fente labio-palatine / orthopédie préchirurgicale / traitement orthodontique / orthopédie maxillaire Résumé – Les patients ayant une fente labio-palatine (FLP) présentent diverses anomalies maxillo-faciales, associées à un faible potentiel de croissance et de développement des structures. En fonction de leurs manifestations phénotypiques, les FLP sont classées en formes modérées ou sévères. Pendant toutes les étapes de la croissance, les patients doivent être intégrés dans un programme individualisé de contrôle et de stimulation. Par ailleurs, les interventions chirurgicales peuvent comporter des séquelles qui majorent parfois certaines anomalies. Le traitement orthodontique est donc nécessaire et même capital pour obtenir les résultats désirés et assurer un état final harmonieux. Cet article présente un ensemble de mesures (interventions d’orthodontie et d’orthopédie maxillaire) dont l’application permet d’aboutir aux objectifs correspondant aux différentes étapes du développement du sujet et qui s’intègre dans le traitement golbal. Key words: cleft lip and palate / presurgical orthopedic management / orthodontic treatment / maxillofacial orthopedic Abstract – Orthodontic care and treatment in cleft lip and palate patients. The cleft lip and palate patients present alterations accompanied by a low growth and development potential of the maxillofacial structures. Depending on the phenotypic manifestations, they can be mild or severe. That is why these patients need an integrated and individualized program of control and stimulation during the growing stage. On the other hand, it is well known that the secondary problems resulted by surgical procedures may increase these alterations, making the orthodontics therapy being a great importance to obtain the correct balance, harmony and satisfactory results. This article presents the general orthopedics and orthodontics indicated to achieve optimal results in different stages during development and evolution of the multidisciplinary treatment. L’orthodontiste joue un rôle fondamental dans le traitement intégré des patients ayant des malformations craniomaxillo-faciales. Il contribue très tôt à la réhabilitation des patients ayant une fente labio-palatine (FLP) ou une autre anomalie dento-faciale. Il stimule la croissance et le développement des structures formant cette région, en utilisant des appareils orthopédiques fonctionnels. Par la suite, avec le traitement orthodontique, il complète le traitement des autres spécialistes du groupe multidisciplinaire participant à la prise en charge de ces patients. Pour les étapes tardives (patients n’ayant pas bénéficié d’une prise en charge * précoce), il contribue à la réhabilitation et cherche à obtenir un état stable à long terme du patient et l’amène à un état de santé physique et mental optimal . Objectifs On doit s’efforcer de soigner et de traiter tous les patients ayant une FLP pour empêcher le développement de troubles de l’occlusion dentaire, afin de prévenir ou de diminuer les manifestations et les séquelles anatomiques et fonctionnelles secondaires. Correspondance : orthodontie.haiti@yahoo.fr 33 Article publié par EDP Sciences Med Buccale Chir Buccale 2013;19:33-38 a E. Beljour et al. b c d Fig. 1. A : vue de face, B : vue de profil, C : vue inférieure, D : vue intra-buccale. Fig. 1. A: frontal view, B: lateral view, C: basal view, D: intraoral view. L’orthopédie fonctionnelle permet de réorienter la croissance de la région dento-faciale et d’obtenir une relation harmonieuse entre les os de la face donnant ainsi au sujet une occlusion fonctionnelle et esthétique stable. Avec un bon contrôle de la croissance, on pérennise le résultat des interventions chirurgicales et on obtient un équilibre optimum des maxillaires. La comparaison des l’état initial et de l’état final permet d’évaluer l’efficacité du traitement . Étape initiale : étude et traitement Orthopédie pré-chirurgicale Pendant les premiers mois, avant l’intervention de chirurgie réparatrice, l’orthopédie permet de stimuler et de mobiliser les segments maxillaires. Elle a pour objectif de repositionner, d’aligner et de réduire les segments maxillaires en les ramenant à une distance minimale afin de pouvoir effectuer une fermeture chirurgicale dans les meilleures conditions. Cette façon de procéder offre plusieurs avantages : elle permet de réaliser une fermeture de la lèvre sans tension, de restaurer le contour normal de l’arcade maxillaire, de faciliter l’alimentation er de repositionner les cartilages des ailes du nez et de la cloison nasale . Cette technique met à profit la malléabilité des cartilages et des segments osseux pendant les premières semaines de la vie. L’établissement d’un diagnostic initial très précoce permet d’identifier le type de FLP et de choisir les mesures thérapeutiques spécifiques pour le cas. La première étape est celle de l’orthopédie pré-chirurgicale qui s’applique de la naissance au 3ème mois. Dès la première visite, on procède á la prise des photographies extra et intra-buccales et à la prise d’empreinte pour la confection de modèles d’étude du procès alvéolaire supérieur. Des photographies extra-buccales sont prises systématiquement de face, de profil des deux côtés et en vue inférieure ; les photographies intra-buccales sont prises avec un miroir ce qui donne une bonne vue d’ensemble de la FLP . Les modèles permettent d’affiner le diagnostic et de fabriquer l’appareil indiqué. Pour les empreintes, 34 on utilise un élastomère, le polyvinyle de siloxane, car c’est un produit facile à contrôler ; le patient doit être placé dans une position inclinée, la tête en bas, pour éviter d’éventuelles complications par obstruction des voies respiratoires. Lors de l’auscultation, on doit considérer trois régions anatomiques spécifiques : le nez, le palais primaire et le palais secondaire. Le cartilage alaire constitue le cartilage le plus affecté ; il est déplacé dans les trois plans de l’espace, de façon proportionnelle à la taille de la fente. On distingue trois degrés selon l’importance de la fente . Dans le degré léger, on observe un déplacement horizontal vers le bas et en dehors de la pointe et de l’aile du nez du côté de la fente. Dans le degré modéré, un déplacement dans le plan horizontal et le plan vertical vers le bas, en dessous du plancher nasal, du côté de la fente. Dans le degré sévère, un déplacement dans les trois plans (horizontal, vertical et frontal) de la pointe et de l’aile du nez du côté de la fente. On y ajoute un composé septal lequel se trouve dévié à un degré allant de léger à modéré. Pour le palais primaire, on mesure la distance entre les bords de la FLP ; ceux-ci peuvent être alignés ou effondrés. Pour une FLP bilatérale, la distance entre le bord du maxillaire et le bord du prémaxillaire de chaque côté. Pour le palais secondaire, la distance entre les segments palatins à hauteur de la limite palais dur–palais mou. Pour réaliser le traitement d’orthopédie pré-chirurgical, on dispose de plusieurs appareils : plaques passives, plaques de pression sélective, appareil de Grayson, appareils pour étendre et élargir les orifices narinaires… Chaque appareil possède des indications spécifiques mais le choix dépend aussi des habitudes du praticien . L’appareil choisi doit être utilisé pendant trois mois et rester en bouche 10 heures par jour. Toutes les semaines, l’enfant est revu en consultation afin de réajuster l’appareil ou de le changer si nécessaire. Avant la chéiloplastie, on répète à nouveau toute la procédure initiale : prise de photographies, mesure de la taille de la FLP pour vérifier l’efficacité du traitement et réévaluer le patient avant l’intervention chirurgicale. Après la chéiloplastie, les consultations restent fréquentes (une fois pas semaine) pour surveiller si la pression secondaire au processus Med Buccale Chir Buccale 2013;19:33-38 a E. Beljour et al. b c Fig. 2. A : plaque de pression sélective avec extensions nasales, B : appareil de Grayson, C : plaque passive. Fig. 2. A: selective pressure device with nasal stents, B: Grayson's molding plate, C: passive plate. a b c Fig. 3. A : plaque de contention avec extensions nasales, B : conformateur nasal bilatéral avec appui céphalique, C : conformateur avec vis d’expansion. Fig. 3. A: retention plate with nasal stents, B: bilateral nasal splint with cranial support, C: splint with expansion screw. de cicatrisation n’affecte pas la croissance et le développement des structures. L’étape suivante s’étend normalement du troisième au douzième mois. On prend à nouveau des photos intra et extrabuccales et des empreintes pour réaliser des modèles d’étude. Les modèles sont utilisés pour la fabrication des appareils d’orthodontie et des mainteneurs d’espace. L’objectif de cette étape est de contenir les segments palatins, réduire la taille de la fente palatine et de tonifier les muscles pour rapprocher les segments palatins . L’auscultation nasale se fait de la même façon que lors de la première consultation. Pour allonger ou étendre le pilier et les orifices nasaux, et redonner au contour nasal sa forme, on utilise la plaque de Grayson, un appareil fait avec du fil orthodontique TMA 0.32 ou une plaque passive en résine acrylique avec deux extensions nasales en fil d’acier inoxydable, portant des conformateurs avec une vis. On utilise cette plaque quand il y a un effondrement important du nez. On active le vis une fois par semaine. L’appareil est utilisé tous les jours jusqu’à la fermeture chirurgicale du palais et on cesse d’activer la vis d’expansion nasale lorsqu’on a obtenu la symétrie des orifices narinaires. Il est recommandé aux parents de laver l’appareil tous les jours avec de l’eau et du savon . Le patient est vu en contrôle tous les mois et, à chaque consultation, on évalue la forme, la position et la direction de l’aile narinaire du côté affecté, le pilier nasal et la fente. En fonction de l’évolution et de l’avis de l’équipe interdisciplinaire, on programme la 2e intervention chirurgicale, la plastie palatine, qui comporte ou non un temps pharyngé. Période post-palatoplastie Après la fermeture du palais, on répète les mêmes procédures, en particulier la prise des photographies intra-buccales pour repérer une éventuelle anomalie ou fistule ; des photographies extra-buccales pour évaluer la taille du pilier nasal et la symétrie des orifices narinaires. L’objectif est de maintenir la stabilité des segments maxillaires et de la forme du nez. Pour réaliser ces objectifs, on utilise une plaque acrylique de contention avec des extensions nasales. Il est recommandé de l’utiliser tous les jours et les contrôles se font tous les mois. Orthopédie maxillaire En général, cette étape s’étend de 2 ans à 5 ans. De nouveau, on effectue un suivi photographique et des radiographies panoramiques et du crâne de profil. On réalise des modèles d’étude pour suivre l’évolution de l’occlusion : on évalue la forme de l’arcade dentaire, la présence d’occlusion croisée antérieure et/ ou postérieure, les distances intermolaire et inter-canine, les classes molaire et canine (I, II et III), l’over-jet, l’over-bite et la profondeur du palais. 35 Med Buccale Chir Buccale 2013;19:33-38 E. Beljour et al. Fig. 4. Modèle d’étude. Fig. 4. Study model. a b c Fig. 5. A : régulateur de fonction de Franckel, B : plaque d’expansion avec recouvrement occlusal et crochets pour le masque facial, C : masque facial. Fig. 5. A: Frankel functional regulator, B: expansion plate with occlusal covering and hooks for face mask, C: face mask. Sur la radiographie panoramique, on recherche la présence ou non de dents surnuméraires et/ou ectopiques, d’agénésie, on évalue la forme du corps et des ramus mandibulaires, la symétrie et le parallélisme des condyles. Sur la téléradiographie de profil, les relations antéro-postérieure et verticale des maxillaires entre eux et avec la base du crâne. L’objectif général est de corriger les décalages antéropostérieur, frontal et vertical du maxillaire et de la mandibule. Pour ce, on utilise un appareil intra-oral avec une vis d’expansion et des crochets en fil d’acier inoxydable, placés dans la région des canines et qui ont des supports dans la région molaire et au palais, pour adapter le masque facial. On peut aussi utiliser un appareil de stimulation musculaire (myo-fonctionnel) pour corriger le décalage inter-maxillaire, rééduquer la musculature péribuccale dans le cas où il existe des anomalies des praxies fonctionnelles. Il est recommandé d’utiliser le masque facial 12 à 14 heures par jour, et l’activation de la vis se fait en fonction du cas et de l’appareil . On effectue une consultation mensuelle pour évaluer l’évolution et ajuster ou modifier l’appareil si nécessaire. Greffe osseuse Cette intervention chirurgicale est effectuée entre 6 et 11 ans. En plus des éléments habituels, on doit disposer d’une radiographie occlusale et, dans certains cas, d’une tomographie. Sur la téléradiographie de profil, on réalise le tracé de l’analyse céphalométrique pour compléter le diagnostic. Il existe plusieurs types d’analyse céphalométrique (Ricketts, Jarabak, Tweed, Steiner…). Elle permet de diagnostiquer la position et la relation des maxillaires avec la base du crâne 36 (14-17). Les normes les plus utilisées sont celles de Steiner, en particulier l’angle SNA (selle turcique-nasion-point A), l’angle SNB (selle turcique-nasion-point B) et l’angle ANB qui donne la relation entre le maxillaire et la mandibule, donc le type de la classe squelettique . Sur la radiographie panoramique , on examine la présence des dents et leur taille pour décider de réaliser, si nécessaire, certaines extractions pour créer de l’espace. La radiographie occlusale donne la position et la forme des canines supérieures, et la taille de la fente après la fermeture du palais. Avec le traitement orthodontique, on cherche à aligner les dents permanentes présentes en bouche mais aussi à corriger le décalage sagittal, frontal et vertical maxillo-mandibulaire avant de réaliser la greffe osseuse alvéolaire secondaire. Pour ce traitement, on utilise des appareils intra-oraux ayant des supports dentaires et muqueux avec des vis d’expansion et des crochets pour utiliser éventuellement le masque facial. On peut aussi utiliser des appareils type Franckel ou Bimler et/ou des appareils orthodontiques classiques. Le traitement dure jusqu’à obtention d’une relation et d’une position adéquates du maxillaire et de la mandibule. Les consultations sont mensuelles et, à la fin de cette étape, on évalue une nouvelle fois les relations dentaires et squelettiques . Orthodontie conventionnelle et orthodontie pré-chirurgicale tardive Cette phase s’étend de 12 à 16 ans. Il est nécessaire comme pour les étapes précédentes, de faire une évaluation complète avec tous les éléments de diagnostic nécessaires comme les Med Buccale Chir Buccale 2013;19:33-38 E. Beljour et al. Fig. 6. Angles SNA, SNA et ANB et leurs valeurs normales. Fig. 6. SNA and SNB angles and their normal values. Fig. 8. Appareil orthodontique avec barre palatine. Fig. 8. Orthodontic appliance with transpalatal bar. Fig. 7. Radiographie panoramique. Fig. 7. Panoramic radiography. photographies, les modèles, les radiographies etc. À ce stade, on évalue le profil, la compétence labiale, l’occlusion dentaire, la symétrie faciale, les sinus maxillaires, le squelette, la classe dentaire et la classe squelettique avec l’aide de la céphalométrie. Les modèles sont utilisés pour fabriquer non seulement l’appareil de notre choix, mais aussi pour effectuer un montage sur articulateur semi-adaptable pour visualiser l’objectif du traitement, en simulant l’intervention chirugicale sur les modèles et en confectionnant un guide chirugical. L’objectif de cette étape est de corriger la malocclusion, puis de décompenser l’occlusion pour préparer et coordonner les arcades et la stabilité occlusale. On utilise un appareil orthodontique fixe ; la technique et la biomécanique utilisées varient avec le spécialiste en orthodontie . Généralement, a b il faut compter 24 mois avant d’arriver à une relation adéquate entre les dents et les arcades en vue de l’intervention de chirurgie maxillo-faciale. Puis, on réévalue le cas et on réalise une étude céphalométrique pour décider le type d’intervention que l’on doit réaliser et pour savoir de combien de millimètres il faut avancer le maxillaire pour corriger la relation maxillomandibulaire . Avec le modèle des deux arcades, on contrôle l’occlusion pour éviter toute interférence occlusale et on réalise un montage sur articulateur pour obtenir la relation maxillomandi-bulaire par rapport à la base du crâne. On réalise l’intervention chirurgicale sur les modèles montés sur articulateur et on confectionne le guide occlusal chirurgical qui servira de référence per-opératoire. Orthodontie postchirurgicale Cette étape s’étend du 3e jour postopératoire jusqu’à l’obtention d’une occlusion fonctionnelle et esthétique, stable. c d Fig. 9. Relation maxillo-mandibulaire avant (A et C) et après (B et D) l’intervention de chirurgie maxillo-faciale. Fig. 9. Intermaxillary relationship before (A & C) and after (B & D) maxillofacial surgery. 37 Med Buccale Chir Buccale 2013;19:33-38 Parfois, il est nécessaire d’utiliser des élastiques intermaxillaires pour maintenir l’occlusion, orienter les mouvements mandibulaires et contrecarrer les forces musculaires qui pourraient provoquer une récidive (21, 22). Il est important de ne pas utiliser les élastiques de manière prolongée pour éviter de créer une pseudo-arthrose. Ensuite, on réalise le dernier mouvement orthodontique pour terminer le traitement. Lorsque la stabilité des segments osseux est effective, on reprend les modèles d’étude et une radiographie panoramique pour analyser l’occlusion, et le parallélisme radiculaire avant de procéder à la dépose des appareils et la pose des arcs de contention. Si nécessaire, on réfère le patient à un confrère effectuer la réhabilitation prothétique. Conclusion Il a été démontré que l’application précoce de ces appareils et accessoires diminue le nombre d’interventions chirurgicales et améliore l’aspect physique du patient, ce qui a un retentissement psychologique et émotionnel favorable sur l’enfant et les parents. Le traitement multidisciplinaire et dynamique donne la possibilité de soigner les patients présentant une FLP et d’éduquer les parents en leur donnant une information adéquate et orientée qui permet, avec la participation de toute l’équipe, d’améliorer la vie de ces patients. Conflits d’intérêt : aucun Références 1. 2. 3. 4. 5. 6. 38 Berkowitz S. Cleft lip and palate diagnosis and a management, 2nd ed. Springer, London, 1996. Haas AJ. Palatal expansion: just the beginning of dentofacial orthopedics. Am J Orthod 1970;57:219-55. Kernahan DA, Stark RB. A new classification for cleft lip and palate. Plast Recons Surg 1958;22:435. Ortiz-Posadas MR, Vega-Alvarado L, Maya-Behar J. A new approach to classify cleft lip and palate. Cleft Pal Craniofac J 2001;38:545-50. Berkowitz S, Duncan R. Timing of cleft palate closure should be based on the radio of the area of the cleft to that of the palatal segments and not on age alone. Plast Recons Surg 2005;115:1483-99. Evans CA. Orthodontic treatment for patients with clefts. Clin Plast Surg 2004;31:271-90. E. Beljour et al. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. Grayson BH, Santiago PE, Brecht LE, Cutting CB. Presurgical nasoalveolar molding in infants with cleft lip and palate. Cleft Palate Craniofac J 1999;36:486-98. Grayson BH, Cutting CB. Presurgical nasoalveolar orthopedic molding in primary correction of the nose, lip and alveolus of infants born with unilateral and bilateral clefts. Cleft Palate Craniofac J 2001;38:193-8. Yeow VK, Chen PK, Chen YR, Noordhoff SM. The use of nasal splints in the primary management of unilateral cleft nasal deformity. Plast Reconstr Surg 1999;103:1347-54. Cutting C, Grayson B, Brecht L, Santiago P, Wood R, Kwon S. Presurgical columellar elongation and primary retrograde nasal reconstruction in one-stage bilateral cleft lip and nose repair. Plast Reconstr Surg 1998;101:630-6. Kozelj V. Experience with presurgical nasal molding in infants with cleft lip and nose deformity. Plast Reconstr Surg 2007;120:738-45. Frankel R. Maxillary retrusion in Class III and treatment with the functional corrector III. Trans Eur Orthod Soc 1970;249-59. Mc Namara JA Jr, Huge SA. The functional regulator (FR-3) of Fränkel. Am J Orthod 1985;88:409-24. Ricketts RM, Bench RW, Hilgers JJ, Schulhof R. An overview of computerized cephalometrics. Am J Orthod 1972;61:1-28. Steiner CC. Cephalometrics for you and me. Am J Orthod 1953;39:729-55. Steiner CC. The use of cephalometrics as an aid to planning and assessing orthodontic treatment. Am J Orthod 1960;46:721-35. Tweed CH. The Frankfort-mandibular incisor angle (FMIA) in orthodontic diagnosis, treatment planning, and prognosis. Angle Orthod 1964;24:121-69. Friede H, Johanson B. A follow-up study of cleft children treated with primary bone grafting. 1. Orthodontic aspects. Scand J Plast Reconstr Surg 1974;8:88-103. Lilja J, Moller M, Friede H, Lauritzen C, Petterson LE, Johanson B. Bone grafting at the stage of mixed dentition in cleft lip and palate patients. Scand J Plast Surg Hand Surg 1987;21:73-9. Johanson B, Ohlsson A, Friede H, Ahlgren J. A follow-up study of cleft lip and palate patients treated by orthodontics, secondary bone grafting and prosthetic rehabilitation. Scand J Plast Reconstr Surg 1974;8:121-35. Delaire J. Confection du masque orthopédique. Rev Stomatol Chir Maxillofac 1971;72:579-84. Delaire J. L’articulation fronto-maxillaire: bases théoriques et principes généraux d'application de forces extraorales postéroantérieures sur masque orthopédique. Rev Stomatol Chir Maxillofac 1976;77:921-30.
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Le développement des techniques de séquençage massif bouleverse notre compréhension des processus de transformation à l’origine des hémopathies malignes. Ces approches permettent d’identifier de nombreuses mutations acquises dans des maladies malignes dont les bases moléculaires étaient jusqu’à aujourd’hui mal connues. L’analyse des conséquences prévisibles de ces mutations a permis d’identifier des processus biologiques dont la dérégulation participerait aux mécanismes de transformation.
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"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
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Dans une série de travaux publiés récemment, les séquences codantes de l’ADN obtenu à partir des cellules mononucléées de la moelle osseuse de patients souffrant d’un syndrome myélodysplasique 1 (SMD) ont été comparées à celles de l’ADN de cellules considérées comme exemptes de la maladie (lymphocytes T ou prélèvement jugal) [ 1 – 3 ]. Cette approche a permis d’identifier en moyenne 10 mutations acquises par échantillon et de confirmer la fréquence des mutations déjà connues dans cette maladie. Elle a révélé l’existence de mutations touchant des gènes dont les produits sont impliqués dans le contrôle du mécanisme d’épissage des ARN messagers ( Tableau I ) . Les mutations de cette catégorie de gènes sont trouvées dans 45 à 85 % des SMD, et sont le plus souvent mutuellement exclusives. La majorité des mutations observées sont des mutations faux-sens, situées dans des régions restreintes des protéines. Les mutations du gène SF3B1 sont observées plus fréquemment dans les SMD avec sidéroblastes en couronne 2 . Ces mutations de SF3B1 ont été décrites comme étant un critère de bon pronostic indépendant dans les SMD, mais ce point n’est pas consensuel .
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[
"Frederik Damm",
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"Y Shiraishi",
"E Papaemmanuil",
"M Cazzola",
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"D Shen",
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"C Quivoron",
"L Couronne",
"V Della Valle",
"A Yokoi",
"Y Kotake",
"K Takahashi",
"D Rossi",
"A Bruscaggin",
"V Spina",
"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
|
N/A
|
N/A
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Génétique des hémopathies malignes : les apports des techniques de séquençage massif
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Tableau I. Mutations des gènes codant pour des protéines impliquées dans la biologie de l’ARN dans les hémopathies myéloïdes et les LLC. Données provenant des références . SMD : syndrome myélodysplasique ; SMP : syndrome myéloprolifératif ; LMMC : leucémie myélomonocytaire chronique ; LAM : leucémie aiguë myéloïde ; LLC : leucémie lymphoïde chronique. Pour la dénomination des gènes, voir Glossaire . Gène SMD sans sidéroblastes en couronne SMD avec sidéroblastes en couronne SMP LMMC LAM LLC SF3B1 6,5 % (10/155) 75,3 % (55/73) 0 % (0/53) 4,5 % (4/88) 3,2 % (7/213) 9,7 % (27/279) SRSF2 11,6 % (18/155) 5,5 % (4/73) 1,9 % (1/53) 28,4 % (25/88) 2,3 % (5/213) ZRSR2 7,7 % (12/155) 1,4 % (1/73) 1,9 % (1/53) 8 % (7/88) 0,5 % (1/213) 1 % (1/105) U2AF35 11,6 % (18/155) 0 % (0/73) 1,9 % (1/53) 8 % (7/88) 3,8 % (8/213) 8,7 % (13/150) U2AF65 0,6 % (1/155) 0 % (0/73) 0 % (0/53) 1,1 % (1/88) 0 % (0/213) 1,9 % (2/105) SF3A1 1,3 % (2/155) 0 % (0/73) 0 % (0/53) 1,1 % (1/88) 0,9 % (2/213) SF1 1,3 % (2/155) 0 % (0/73) 1,9 % (1/53) 0 % (0/88) 0 % (0/213) PRPF40B 1,9 % (3/155) 0 % (0/73) 1,9 % (1/53) 0 % (0/88) 0,9 % (2/213) NXF1 4,7 % (1/21) 0 % (0/4) 0 % (0/7) 2,8 % (3/105) XPO1 12,5 % (1/8) 2,4 % (4/165) 0 % (0/21) 1,9 % (2/105) 1 % (1/91)
|
[
"Frederik Damm",
"Florence Nguyen-Khac",
"Olivier Kosmider",
"Michaela Fontenay",
"Olivier A. Bernard",
"K Yoshida",
"M Sanada",
"Y Shiraishi",
"E Papaemmanuil",
"M Cazzola",
"J Boultwood",
"TA Graubert",
"D Shen",
"L Ding",
"MM Patnaik",
"TL Lasho",
"JM Hodnefield",
"F Damm",
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"L Wang",
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"Y Wan",
"V Quesada",
"L Conde",
"N Villamor",
"AA Ferrando",
"M Di Ianni",
"S Baldoni",
"E Rosati",
"G Fabbri",
"S Rasi",
"D Rossi",
"XS Puente",
"M Pinyol",
"V Quesada",
"E Hiriart",
"H Gruffat",
"M Buisson",
"S Xu",
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"HR Christofk",
"MG Vander Heiden",
"MH Harris",
"M Gabut",
"P Samavarchi-Tehrani",
"X Wang",
"RF Luco",
"T Misteli",
"MA Chapman",
"MS Lawrence",
"JJ Keats",
"L Ding",
"TJ Ley",
"DE Larson",
"BL Ebert",
"TL Lasho",
"CM Finke",
"CA Hanson",
"Y Kikushige",
"F Ishikawa",
"T Miyamoto",
"C Quivoron",
"L Couronne",
"V Della Valle",
"A Yokoi",
"Y Kotake",
"K Takahashi",
"D Rossi",
"A Bruscaggin",
"V Spina",
"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
|
N/A
|
N/A
|
fr
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Génétique des hémopathies malignes : les apports des techniques de séquençage massif
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Des analyses similaires ont été réalisées dans la leucémie lymphoïde chronique (LLC). Dans cette maladie, le génome de cellules tumorales - des lymphocytes B CD19 + CD5 + - a été comparé à celui de cellules contrôles non tumorales, soit granuleuses, soit fibroblastiques . Dans une première publication, des mutations de onze gènes ont été identifiées de façon récurrente, dont certains déjà connus dans cette pathologie, tels que TP53 et ATM (voir Glossaire) ( Tableau II ) . Les prédictions fonctionnelles montrent que ces gènes interviennent normalement dans cinq processus cellulaires : la réparation des dommages de l’ADN et le cycle cellulaire, la voie de signalisation Wnt, la voie de signalisation NOTCH1, les voies de signalisation de l’inflammation, et les mécanismes de contrôle de l’épissage . Lorsque les échantillons présentent des mutations des régions hypervariables des gènes codant pour les chaînes lourdes des immunoglobulines (IGHV) remaniés, le nombre de mutations acquises modifiant la séquence codante est supérieur (12,8 par échantillon) à ce qu’il est dans les échantillons dépourvus de ces mutations somatiques (10,6 par échantillon) . Des mutations des gènes POT1 - dont le produit est impliqué dans la biologie des télomères -, CHD2 - dont le produit est impliqué dans le contrôle de la structure chromatinienne -, et LRP1B - un gène candidat suppresseur de tumeur -, allongent la liste des gènes fréquemment mutés dans les LLC.
|
[
"Frederik Damm",
"Florence Nguyen-Khac",
"Olivier Kosmider",
"Michaela Fontenay",
"Olivier A. Bernard",
"K Yoshida",
"M Sanada",
"Y Shiraishi",
"E Papaemmanuil",
"M Cazzola",
"J Boultwood",
"TA Graubert",
"D Shen",
"L Ding",
"MM Patnaik",
"TL Lasho",
"JM Hodnefield",
"F Damm",
"F Thol",
"O Kosmider",
"L Wang",
"MS Lawrence",
"Y Wan",
"V Quesada",
"L Conde",
"N Villamor",
"AA Ferrando",
"M Di Ianni",
"S Baldoni",
"E Rosati",
"G Fabbri",
"S Rasi",
"D Rossi",
"XS Puente",
"M Pinyol",
"V Quesada",
"E Hiriart",
"H Gruffat",
"M Buisson",
"S Xu",
"MA Powers",
"HR Christofk",
"MG Vander Heiden",
"MH Harris",
"M Gabut",
"P Samavarchi-Tehrani",
"X Wang",
"RF Luco",
"T Misteli",
"MA Chapman",
"MS Lawrence",
"JJ Keats",
"L Ding",
"TJ Ley",
"DE Larson",
"BL Ebert",
"TL Lasho",
"CM Finke",
"CA Hanson",
"Y Kikushige",
"F Ishikawa",
"T Miyamoto",
"C Quivoron",
"L Couronne",
"V Della Valle",
"A Yokoi",
"Y Kotake",
"K Takahashi",
"D Rossi",
"A Bruscaggin",
"V Spina",
"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
|
N/A
|
N/A
|
fr
| 0.999998
| 3.122513
| 4.075633
| 3.387143
| 4.266872
| 0.008245
| 1.024672
| -0.000791
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0112B54A652D9818D8F6CBDFC132BBE045FD1133
|
sec[0]/p[4]
|
Génétique des hémopathies malignes : les apports des techniques de séquençage massif
| 4.398438
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Study
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Tableau II. Principaux gènes mutés dans les LLC. NGS : next generation sequencing ; les gènes indiqués en gras ont une fonction définie. Dénomination des gènes , voir Glossaire. Gène Fréquence Fonction Remarque Références TP53 15 % (15/91) Contrôle des dommages à l’ADN et du cycle cellulaire NGS SF3B1 15 % (14/91) Métabolisme de l’ARN NGS SF3B1 9,5 % (10/105) NGS SF3B1 5 % (17/301) Échantillons successifs SF3B1 17 % (10 of 59) Échantillons résistants à la fludarabine MYD88 10 % (9/91) Inflammation et voies de signalisation NFκB et JAK NGS MYD88 2,8 % (3/105) NGS ATM 9 % (9/91) Contrôle des dommages à l’ADN et du cycle cellulaire NGS ATM 3,8 % (4/105) NGS NOTCH1 4 % (4/91) Voie Notch NGS NOTCH1 4,7 % (5/105) NGS NOTCH1 8,3 % Échantillons au diagnostic NOTCH1 (31,0 %) Transformation (Richter) NOTCH1 (20,8 %) Échantillons chimiorésistants FBWX7 4 % (4/91) Voie Notch NGS ZMYM3 4 % (4/91) Histone déacétylase - structure chromatinienne NGS ZMYM3 1,9 % (2/105) NGS un exemple de mutation dans ZMYM1 DDX3X 3 % (3/91) Métabolisme de l’ARN NGS DDX3X 1,9 % (2/105) Métabolisme de l’ARN NGS MAPK1 3 % (3/91) Inflammation et voies de signalisation NFκB et JAK NGS l CHD2 4,7 % (5/105) Hélicase - structure chromatinienne NGS CHD2 1 % (1/91) NGS POT1 4,7 % (5/105) Biologie des télomères NGS POT1 1 %(1/91) NGS ASXL1 2,8 % (3/105) Polycomb NGS ASXL1 1 % (1/91) NGS NXF1 2,8 % (3/105) Métabolisme de l’ARN NGS SFRS1 1,9 % (2/105) Métabolisme de l’ARN NGS U2AF65 1,9 % (2/105) Métabolisme de l’ARN NGS U2AF65 1 % (1/91) NGS XPO1 1,9 % (2/105) Métabolisme de l’ARN NGS XPO1 1 % (1/91) NGS
|
[
"Frederik Damm",
"Florence Nguyen-Khac",
"Olivier Kosmider",
"Michaela Fontenay",
"Olivier A. Bernard",
"K Yoshida",
"M Sanada",
"Y Shiraishi",
"E Papaemmanuil",
"M Cazzola",
"J Boultwood",
"TA Graubert",
"D Shen",
"L Ding",
"MM Patnaik",
"TL Lasho",
"JM Hodnefield",
"F Damm",
"F Thol",
"O Kosmider",
"L Wang",
"MS Lawrence",
"Y Wan",
"V Quesada",
"L Conde",
"N Villamor",
"AA Ferrando",
"M Di Ianni",
"S Baldoni",
"E Rosati",
"G Fabbri",
"S Rasi",
"D Rossi",
"XS Puente",
"M Pinyol",
"V Quesada",
"E Hiriart",
"H Gruffat",
"M Buisson",
"S Xu",
"MA Powers",
"HR Christofk",
"MG Vander Heiden",
"MH Harris",
"M Gabut",
"P Samavarchi-Tehrani",
"X Wang",
"RF Luco",
"T Misteli",
"MA Chapman",
"MS Lawrence",
"JJ Keats",
"L Ding",
"TJ Ley",
"DE Larson",
"BL Ebert",
"TL Lasho",
"CM Finke",
"CA Hanson",
"Y Kikushige",
"F Ishikawa",
"T Miyamoto",
"C Quivoron",
"L Couronne",
"V Della Valle",
"A Yokoi",
"Y Kotake",
"K Takahashi",
"D Rossi",
"A Bruscaggin",
"V Spina",
"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
|
N/A
|
N/A
|
fr
| 0.999997
| 1.849265
| 3.550889
| 3.079793
| 4.040473
| 0.035744
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0112B54A652D9818D8F6CBDFC132BBE045FD1133
|
sec[0]/p[5]
|
Génétique des hémopathies malignes : les apports des techniques de séquençage massif
| 4.074219
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|
biomedical
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Ces résultats pourraient avoir une application clinique. En effet, les mutations de certains gènes semblent associées aux critères cliniques ou biologiques caractéristiques de la LLC. Par exemple, les mutations de NOTCH1 et de FBXW7 sont associées à la présence d’une trisomie 12 et à un statut non muté des IGHV . Les mutations de MYD88 sont associées au caractère muté des IGHV et aux délétions de la région chromosomique 13q14 . Les mutations de SF3B1 sont associées aux délétions de la région chromosomique 11q22 (et aux mutations du gène ATM qui est localisé dans cette région), à un mauvais pronostic et une résistance à la fludarabine.
|
[
"Frederik Damm",
"Florence Nguyen-Khac",
"Olivier Kosmider",
"Michaela Fontenay",
"Olivier A. Bernard",
"K Yoshida",
"M Sanada",
"Y Shiraishi",
"E Papaemmanuil",
"M Cazzola",
"J Boultwood",
"TA Graubert",
"D Shen",
"L Ding",
"MM Patnaik",
"TL Lasho",
"JM Hodnefield",
"F Damm",
"F Thol",
"O Kosmider",
"L Wang",
"MS Lawrence",
"Y Wan",
"V Quesada",
"L Conde",
"N Villamor",
"AA Ferrando",
"M Di Ianni",
"S Baldoni",
"E Rosati",
"G Fabbri",
"S Rasi",
"D Rossi",
"XS Puente",
"M Pinyol",
"V Quesada",
"E Hiriart",
"H Gruffat",
"M Buisson",
"S Xu",
"MA Powers",
"HR Christofk",
"MG Vander Heiden",
"MH Harris",
"M Gabut",
"P Samavarchi-Tehrani",
"X Wang",
"RF Luco",
"T Misteli",
"MA Chapman",
"MS Lawrence",
"JJ Keats",
"L Ding",
"TJ Ley",
"DE Larson",
"BL Ebert",
"TL Lasho",
"CM Finke",
"CA Hanson",
"Y Kikushige",
"F Ishikawa",
"T Miyamoto",
"C Quivoron",
"L Couronne",
"V Della Valle",
"A Yokoi",
"Y Kotake",
"K Takahashi",
"D Rossi",
"A Bruscaggin",
"V Spina",
"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
|
N/A
|
N/A
|
fr
| 0.999996
| 2.793527
| 4.005627
| 2.995207
| 3.987407
| 0.010057
| 0.994603
| -0.000826
| 6.169887
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| 1.703132
|
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|
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|
sec[1]/sec[0]/p[0]
|
Les LLC partagent des mutations avec les autres pathologies lymphoïdes
| 4.433594
| 0.27167
|
biomedical
|
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|
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[
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Des mutations de NOTCH1 sont connues depuis plusieurs années dans les leucémies aiguës lymphoblastiques T (LAL-T) ; elles se traduisent par une activation constitutive de la transcription des gènes cibles de cette voie . Durant sa maturation, la protéine NOTCH1 est clivée en deux parties : une partie extracellulaire (ECN) et une partie intracellulaire (ICN) qui interagissent entre elles. L’interaction de NOTCH1 avec ses ligands libère ICN qui migre dans le noyau où elle interagit avec le facteur de transcription RBPJk et active les gènes cibles de la voie. Dans les LAL-T, les mutations de NOTCH1 peuvent soit faciliter la dissociation de la partie intracellulaire ICN de NOTCH1, soit entraîner la perte du domaine PEST de déstabilisation de ICN. Ce sont des mutations de ce dernier type qui sont présentes dans les LLC, principalement une mutation « saut de phase » touchant le codon correspondant à l’acide aminé P2515 [ 9 – 11 ]. Des mutations de NOTCH1 sont également trouvées dans les lymphomes. Comme pour les LAL-T, des mutations inactivatrices du gène FBXW7 - qui exerce normalement un rétrocontrôle sur la voie NOTCH1 - sont aussi retrouvées dans les LLC .
|
[
"Frederik Damm",
"Florence Nguyen-Khac",
"Olivier Kosmider",
"Michaela Fontenay",
"Olivier A. Bernard",
"K Yoshida",
"M Sanada",
"Y Shiraishi",
"E Papaemmanuil",
"M Cazzola",
"J Boultwood",
"TA Graubert",
"D Shen",
"L Ding",
"MM Patnaik",
"TL Lasho",
"JM Hodnefield",
"F Damm",
"F Thol",
"O Kosmider",
"L Wang",
"MS Lawrence",
"Y Wan",
"V Quesada",
"L Conde",
"N Villamor",
"AA Ferrando",
"M Di Ianni",
"S Baldoni",
"E Rosati",
"G Fabbri",
"S Rasi",
"D Rossi",
"XS Puente",
"M Pinyol",
"V Quesada",
"E Hiriart",
"H Gruffat",
"M Buisson",
"S Xu",
"MA Powers",
"HR Christofk",
"MG Vander Heiden",
"MH Harris",
"M Gabut",
"P Samavarchi-Tehrani",
"X Wang",
"RF Luco",
"T Misteli",
"MA Chapman",
"MS Lawrence",
"JJ Keats",
"L Ding",
"TJ Ley",
"DE Larson",
"BL Ebert",
"TL Lasho",
"CM Finke",
"CA Hanson",
"Y Kikushige",
"F Ishikawa",
"T Miyamoto",
"C Quivoron",
"L Couronne",
"V Della Valle",
"A Yokoi",
"Y Kotake",
"K Takahashi",
"D Rossi",
"A Bruscaggin",
"V Spina",
"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
|
N/A
|
N/A
|
fr
| 0.999996
| 3.193285
| 4.075415
| 3.41879
| 4.305577
| -0.00908
| 1.044438
| 0.001352
| 5.468856
| -3.575979
| 4.676682
| 0.996656
| 1.038734
| 0.044685
| 1.931388
|
medical_knowledge
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|
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0112B54A652D9818D8F6CBDFC132BBE045FD1133
|
sec[1]/sec[0]/p[1]
|
Les LLC partagent des mutations avec les autres pathologies lymphoïdes
| 3.560547
| 1.923996
|
biomedical
|
Study
|
[
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[
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Des mutations ponctuelles de MYD88 ont déjà été décrites dans des lymphomes de type B. Il s’agit systématiquement de mutations faux-sens de type activateur. Les mutations de MYD88 entraînent l’activation des facteurs de transcription STAT3 et NFkB. La mutation L265P décrite dans les LLC est largement majoritaire dans les lymphomes de type B.
|
[
"Frederik Damm",
"Florence Nguyen-Khac",
"Olivier Kosmider",
"Michaela Fontenay",
"Olivier A. Bernard",
"K Yoshida",
"M Sanada",
"Y Shiraishi",
"E Papaemmanuil",
"M Cazzola",
"J Boultwood",
"TA Graubert",
"D Shen",
"L Ding",
"MM Patnaik",
"TL Lasho",
"JM Hodnefield",
"F Damm",
"F Thol",
"O Kosmider",
"L Wang",
"MS Lawrence",
"Y Wan",
"V Quesada",
"L Conde",
"N Villamor",
"AA Ferrando",
"M Di Ianni",
"S Baldoni",
"E Rosati",
"G Fabbri",
"S Rasi",
"D Rossi",
"XS Puente",
"M Pinyol",
"V Quesada",
"E Hiriart",
"H Gruffat",
"M Buisson",
"S Xu",
"MA Powers",
"HR Christofk",
"MG Vander Heiden",
"MH Harris",
"M Gabut",
"P Samavarchi-Tehrani",
"X Wang",
"RF Luco",
"T Misteli",
"MA Chapman",
"MS Lawrence",
"JJ Keats",
"L Ding",
"TJ Ley",
"DE Larson",
"BL Ebert",
"TL Lasho",
"CM Finke",
"CA Hanson",
"Y Kikushige",
"F Ishikawa",
"T Miyamoto",
"C Quivoron",
"L Couronne",
"V Della Valle",
"A Yokoi",
"Y Kotake",
"K Takahashi",
"D Rossi",
"A Bruscaggin",
"V Spina",
"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
|
N/A
|
N/A
|
fr
| 0.999998
| 2.497294
| 3.993565
| 2.973699
| 4.023665
| 0.000852
| 1.01075
| -0.000279
| 5.894407
| -2.763413
| 5.204522
| 0.803908
| 0.838953
| 0.047901
| 3.100841
|
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|
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|
0112B54A652D9818D8F6CBDFC132BBE045FD1133
|
sec[1]/sec[1]/p[0]
|
Implication récurrente de gènes dont les produits participent à la biologie de l’ARN
| 4.128906
| 0.872414
|
biomedical
|
Study
|
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La surprise de cette série de résultats récents est l’identification de mutations dans des gènes dont les produits sont impliqués dans le contrôle de l’épissage de l’ARN. L’implication d’oncogènes dans les mécanismes de maturation de l’ARN est connue depuis longtemps. On peut citer OTT/RBM15 qui est impliqué dans l’export des ARN messagers vers le cytoplasme et remanié dans les translocations t(1;22)(p13;q13) des leucémies à mégacaryoblastes . Un autre exemple est l’implication des protéines du nucléopore, NUP98 et NUP214, dans des protéines de fusion créées par des remaniements géniques .
|
[
"Frederik Damm",
"Florence Nguyen-Khac",
"Olivier Kosmider",
"Michaela Fontenay",
"Olivier A. Bernard",
"K Yoshida",
"M Sanada",
"Y Shiraishi",
"E Papaemmanuil",
"M Cazzola",
"J Boultwood",
"TA Graubert",
"D Shen",
"L Ding",
"MM Patnaik",
"TL Lasho",
"JM Hodnefield",
"F Damm",
"F Thol",
"O Kosmider",
"L Wang",
"MS Lawrence",
"Y Wan",
"V Quesada",
"L Conde",
"N Villamor",
"AA Ferrando",
"M Di Ianni",
"S Baldoni",
"E Rosati",
"G Fabbri",
"S Rasi",
"D Rossi",
"XS Puente",
"M Pinyol",
"V Quesada",
"E Hiriart",
"H Gruffat",
"M Buisson",
"S Xu",
"MA Powers",
"HR Christofk",
"MG Vander Heiden",
"MH Harris",
"M Gabut",
"P Samavarchi-Tehrani",
"X Wang",
"RF Luco",
"T Misteli",
"MA Chapman",
"MS Lawrence",
"JJ Keats",
"L Ding",
"TJ Ley",
"DE Larson",
"BL Ebert",
"TL Lasho",
"CM Finke",
"CA Hanson",
"Y Kikushige",
"F Ishikawa",
"T Miyamoto",
"C Quivoron",
"L Couronne",
"V Della Valle",
"A Yokoi",
"Y Kotake",
"K Takahashi",
"D Rossi",
"A Bruscaggin",
"V Spina",
"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
|
N/A
|
N/A
|
fr
| 0.999998
| 2.868597
| 3.927485
| 2.992872
| 4.040918
| 0.022156
| 1.01366
| -0.001556
| 6.74408
| -2.679983
| 3.302525
| 0.898403
| 0.594785
| 0.079613
| -0.771508
|
medical_knowledge
| 0.487753
|
questions
| 0.996772
| 0
| 0.999202
| 1
| 0.99994
| 1
| 0.999777
|
0112B54A652D9818D8F6CBDFC132BBE045FD1133_p9
|
0112B54A652D9818D8F6CBDFC132BBE045FD1133
|
sec[1]/sec[1]/p[1]
|
Implication récurrente de gènes dont les produits participent à la biologie de l’ARN
| 4.308594
| 1.772089
|
biomedical
|
Study
|
[
0.99755859375,
0.0004591941833496094,
0.0019521713256835938
] |
[
0.9755859375,
0.0229949951171875,
0.0011758804321289062,
0.0002651214599609375
] |
Dans les SMD, 8 gènes codant pour des protéines impliquées dans l’épissage sont mutés avec une fréquence variable . Hormis les mutations inactivatrices qui touchent - presque uniquement chez les hommes - le gène SRSF2 localisé sur le chromosome X, les autres mutations sont des mutations faux-sens qui s’accumulent à haute densité dans des régions spécifiques de ces gènes, affectant très souvent un acide aminé unique. Ce type de profil de mutation indique souvent un gain de fonction. Ces mutations pourraient affecter l’efficacité de l’assemblage des splicéosomes ou de l’épissage lui-même. L’expression de la plupart des gènes pourrait être affectée du fait du maintien inopportun d’introns dans les transcrits matures, de l’omission d’exons, ou de la dérégulation des épissages alternatifs. Le rôle de l’épissage alternatif dans la différenciation cellulaire a été établi dans plusieurs exemples et la dérégulation de ces processus pourrait participer à la transformation cellulaire ( → ).
|
[
"Frederik Damm",
"Florence Nguyen-Khac",
"Olivier Kosmider",
"Michaela Fontenay",
"Olivier A. Bernard",
"K Yoshida",
"M Sanada",
"Y Shiraishi",
"E Papaemmanuil",
"M Cazzola",
"J Boultwood",
"TA Graubert",
"D Shen",
"L Ding",
"MM Patnaik",
"TL Lasho",
"JM Hodnefield",
"F Damm",
"F Thol",
"O Kosmider",
"L Wang",
"MS Lawrence",
"Y Wan",
"V Quesada",
"L Conde",
"N Villamor",
"AA Ferrando",
"M Di Ianni",
"S Baldoni",
"E Rosati",
"G Fabbri",
"S Rasi",
"D Rossi",
"XS Puente",
"M Pinyol",
"V Quesada",
"E Hiriart",
"H Gruffat",
"M Buisson",
"S Xu",
"MA Powers",
"HR Christofk",
"MG Vander Heiden",
"MH Harris",
"M Gabut",
"P Samavarchi-Tehrani",
"X Wang",
"RF Luco",
"T Misteli",
"MA Chapman",
"MS Lawrence",
"JJ Keats",
"L Ding",
"TJ Ley",
"DE Larson",
"BL Ebert",
"TL Lasho",
"CM Finke",
"CA Hanson",
"Y Kikushige",
"F Ishikawa",
"T Miyamoto",
"C Quivoron",
"L Couronne",
"V Della Valle",
"A Yokoi",
"Y Kotake",
"K Takahashi",
"D Rossi",
"A Bruscaggin",
"V Spina",
"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
|
N/A
|
N/A
|
fr
| 0.999995
| 3.153389
| 3.957569
| 3.017042
| 3.976142
| 0.01052
| 1.028459
| 0.001241
| 6.299137
| -2.465853
| 2.909579
| 1.004689
| 0.854199
| 0.05276
| 2.5068
|
medical_knowledge
| 0.997765
|
questions
| 0.975372
| 0
| 0.99945
| 1
| 0.999987
| 1
| 0.999157
|
0112B54A652D9818D8F6CBDFC132BBE045FD1133_p10
|
0112B54A652D9818D8F6CBDFC132BBE045FD1133
|
sec[1]/sec[1]/p[2]
|
Implication récurrente de gènes dont les produits participent à la biologie de l’ARN
| 0.981934
| -1.060443
|
other
|
Other
|
[
0.08209228515625,
0.0015668869018554688,
0.91650390625
] |
[
0.00952911376953125,
0.98828125,
0.00142669677734375,
0.0006442070007324219
] |
(→) Voir m/s n° 4, avril 2012, pages 372 et 381
|
[
"Frederik Damm",
"Florence Nguyen-Khac",
"Olivier Kosmider",
"Michaela Fontenay",
"Olivier A. Bernard",
"K Yoshida",
"M Sanada",
"Y Shiraishi",
"E Papaemmanuil",
"M Cazzola",
"J Boultwood",
"TA Graubert",
"D Shen",
"L Ding",
"MM Patnaik",
"TL Lasho",
"JM Hodnefield",
"F Damm",
"F Thol",
"O Kosmider",
"L Wang",
"MS Lawrence",
"Y Wan",
"V Quesada",
"L Conde",
"N Villamor",
"AA Ferrando",
"M Di Ianni",
"S Baldoni",
"E Rosati",
"G Fabbri",
"S Rasi",
"D Rossi",
"XS Puente",
"M Pinyol",
"V Quesada",
"E Hiriart",
"H Gruffat",
"M Buisson",
"S Xu",
"MA Powers",
"HR Christofk",
"MG Vander Heiden",
"MH Harris",
"M Gabut",
"P Samavarchi-Tehrani",
"X Wang",
"RF Luco",
"T Misteli",
"MA Chapman",
"MS Lawrence",
"JJ Keats",
"L Ding",
"TJ Ley",
"DE Larson",
"BL Ebert",
"TL Lasho",
"CM Finke",
"CA Hanson",
"Y Kikushige",
"F Ishikawa",
"T Miyamoto",
"C Quivoron",
"L Couronne",
"V Della Valle",
"A Yokoi",
"Y Kotake",
"K Takahashi",
"D Rossi",
"A Bruscaggin",
"V Spina",
"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
|
N/A
|
N/A
|
fr
| 0.999996
| 1.005726
| 3.094742
| 0.963963
| 0.940439
| -0.021947
| -0.002095
| -0.002042
| -0.882973
| -3.541097
| 6.423882
| 1.014275
| 0.264316
| -0.042927
| 4.441303
|
other
| 0.99509
|
questions
| 0.999368
| 0
| 0.999532
| 1
| 0.999964
| 0
| 0.998376
|
0112B54A652D9818D8F6CBDFC132BBE045FD1133_p11
|
0112B54A652D9818D8F6CBDFC132BBE045FD1133
|
sec[1]/sec[1]/p[3]
|
Implication récurrente de gènes dont les produits participent à la biologie de l’ARN
| 3.998047
| 0.636127
|
biomedical
|
Study
|
[
0.99658203125,
0.0006270408630371094,
0.0028820037841796875
] |
[
0.80322265625,
0.1929931640625,
0.0029888153076171875,
0.00067901611328125
] |
Les mutations affectant l’épissage pourraient également entraîner une variation soit de l’efficacité de la transcription en amont, soit de la cinétique de l’export vers le cytoplasme en aval. Les vitesses de transcription, d’épissage et de transport vers le cytoplasme sont liées et influencent la structure chromatinienne . Schématiquement, un ralentissement (ou une accélération) de ces processus pourrait aboutir à la fermeture (ou à l’ouverture) de la chromatine indépendamment de la régulation normale, et donc à des anomalies de la différenciation cellulaire.
|
[
"Frederik Damm",
"Florence Nguyen-Khac",
"Olivier Kosmider",
"Michaela Fontenay",
"Olivier A. Bernard",
"K Yoshida",
"M Sanada",
"Y Shiraishi",
"E Papaemmanuil",
"M Cazzola",
"J Boultwood",
"TA Graubert",
"D Shen",
"L Ding",
"MM Patnaik",
"TL Lasho",
"JM Hodnefield",
"F Damm",
"F Thol",
"O Kosmider",
"L Wang",
"MS Lawrence",
"Y Wan",
"V Quesada",
"L Conde",
"N Villamor",
"AA Ferrando",
"M Di Ianni",
"S Baldoni",
"E Rosati",
"G Fabbri",
"S Rasi",
"D Rossi",
"XS Puente",
"M Pinyol",
"V Quesada",
"E Hiriart",
"H Gruffat",
"M Buisson",
"S Xu",
"MA Powers",
"HR Christofk",
"MG Vander Heiden",
"MH Harris",
"M Gabut",
"P Samavarchi-Tehrani",
"X Wang",
"RF Luco",
"T Misteli",
"MA Chapman",
"MS Lawrence",
"JJ Keats",
"L Ding",
"TJ Ley",
"DE Larson",
"BL Ebert",
"TL Lasho",
"CM Finke",
"CA Hanson",
"Y Kikushige",
"F Ishikawa",
"T Miyamoto",
"C Quivoron",
"L Couronne",
"V Della Valle",
"A Yokoi",
"Y Kotake",
"K Takahashi",
"D Rossi",
"A Bruscaggin",
"V Spina",
"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
|
N/A
|
N/A
|
fr
| 0.999995
| 3.041497
| 4.008345
| 3.013694
| 4.00614
| 0.00752
| 1.045268
| 0.001186
| 6.476674
| -3.140847
| -1.070412
| -0.026108
| -0.013252
| -0.016119
| 2.369096
|
medical_knowledge
| 0.997732
|
questions
| 0.994863
| 0
| 0.960188
| 1
| 0.999881
| 1
| 0.999484
|
0112B54A652D9818D8F6CBDFC132BBE045FD1133_p12
|
0112B54A652D9818D8F6CBDFC132BBE045FD1133
|
sec[1]/sec[1]/p[4]
|
Implication récurrente de gènes dont les produits participent à la biologie de l’ARN
| 3.955078
| -0.343015
|
biomedical
|
Study
|
[
0.99755859375,
0.0004527568817138672,
0.0021820068359375
] |
[
0.88720703125,
0.111083984375,
0.0010700225830078125,
0.00045561790466308594
] |
Il est possible que des altérations touchant d’autres aspects de la biologie de l’ARN jouent également un rôle dans les processus de transformation. Dans les LLC, des mutations de CPSF2 , DDX3X et XPO1 (qui code pour l’exportine 1) ont été décrites. Le produit de CPSF2 est impliqué dans les processus de polyadénylation de l’ARN messager, les protéines de la famille des DEAD-box sont impliquées dans la biologie des ARN et XPO1 participe à l’export nucléocytoplasmique de protéines et d’ARN.
|
[
"Frederik Damm",
"Florence Nguyen-Khac",
"Olivier Kosmider",
"Michaela Fontenay",
"Olivier A. Bernard",
"K Yoshida",
"M Sanada",
"Y Shiraishi",
"E Papaemmanuil",
"M Cazzola",
"J Boultwood",
"TA Graubert",
"D Shen",
"L Ding",
"MM Patnaik",
"TL Lasho",
"JM Hodnefield",
"F Damm",
"F Thol",
"O Kosmider",
"L Wang",
"MS Lawrence",
"Y Wan",
"V Quesada",
"L Conde",
"N Villamor",
"AA Ferrando",
"M Di Ianni",
"S Baldoni",
"E Rosati",
"G Fabbri",
"S Rasi",
"D Rossi",
"XS Puente",
"M Pinyol",
"V Quesada",
"E Hiriart",
"H Gruffat",
"M Buisson",
"S Xu",
"MA Powers",
"HR Christofk",
"MG Vander Heiden",
"MH Harris",
"M Gabut",
"P Samavarchi-Tehrani",
"X Wang",
"RF Luco",
"T Misteli",
"MA Chapman",
"MS Lawrence",
"JJ Keats",
"L Ding",
"TJ Ley",
"DE Larson",
"BL Ebert",
"TL Lasho",
"CM Finke",
"CA Hanson",
"Y Kikushige",
"F Ishikawa",
"T Miyamoto",
"C Quivoron",
"L Couronne",
"V Della Valle",
"A Yokoi",
"Y Kotake",
"K Takahashi",
"D Rossi",
"A Bruscaggin",
"V Spina",
"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
|
N/A
|
N/A
|
fr
| 0.999998
| 2.655913
| 3.995282
| 2.943708
| 3.946975
| -0.02058
| 0.997923
| 0.00307
| 5.938593
| -3.48579
| -0.10601
| 0.19143
| 0.856758
| -0.029329
| 1.508395
|
medical_knowledge
| 0.994507
|
questions
| 0.992479
| 0
| 0.983714
| 1
| 0.999493
| 1
| 0.998928
|
0112B54A652D9818D8F6CBDFC132BBE045FD1133_p13
|
0112B54A652D9818D8F6CBDFC132BBE045FD1133
|
sec[1]/sec[1]/p[5]
|
Implication récurrente de gènes dont les produits participent à la biologie de l’ARN
| 4.335938
| 0.433853
|
biomedical
|
Study
|
[
0.99853515625,
0.0003304481506347656,
0.0013380050659179688
] |
[
0.9921875,
0.006755828857421875,
0.0011415481567382812,
0.00014257431030273438
] |
Des mutations affectant des gènes dont les produits participent au contrôle de la traduction ou de la stabilité des ARNm ont été décrites dans le myélome, un autre type de tumeur de la lignée lymphoïde B . Des mutations de DIS3 (qui code pour une sous-unité catalytique des exosomes) ont été décrites : elles semblent être des mutations inactivatrices, associées à la perte de l’autre copie du gène. Ces mutations pourraient aboutir à une accumulation de certains ARNm et interférer avec le contrôle de la traduction. Des mutations de DIS3 ont par ailleurs été décrites dans des LAM (leucémies aiguës myéloblastiques) et dans deux échantillons de LLC . Des mutations de LRRK2 , dont la protéine est impliquée, entre autres, dans le contrôle de la traduction par ses capacités à phosphoryler le facteur d’initiation de la traduction 4EBP, ont été rapportées. De plus, le gène FAM46C - qui est également muté dans le myélome - jouerait un rôle dans la traduction ou la stabilité de l’ARN.
|
[
"Frederik Damm",
"Florence Nguyen-Khac",
"Olivier Kosmider",
"Michaela Fontenay",
"Olivier A. Bernard",
"K Yoshida",
"M Sanada",
"Y Shiraishi",
"E Papaemmanuil",
"M Cazzola",
"J Boultwood",
"TA Graubert",
"D Shen",
"L Ding",
"MM Patnaik",
"TL Lasho",
"JM Hodnefield",
"F Damm",
"F Thol",
"O Kosmider",
"L Wang",
"MS Lawrence",
"Y Wan",
"V Quesada",
"L Conde",
"N Villamor",
"AA Ferrando",
"M Di Ianni",
"S Baldoni",
"E Rosati",
"G Fabbri",
"S Rasi",
"D Rossi",
"XS Puente",
"M Pinyol",
"V Quesada",
"E Hiriart",
"H Gruffat",
"M Buisson",
"S Xu",
"MA Powers",
"HR Christofk",
"MG Vander Heiden",
"MH Harris",
"M Gabut",
"P Samavarchi-Tehrani",
"X Wang",
"RF Luco",
"T Misteli",
"MA Chapman",
"MS Lawrence",
"JJ Keats",
"L Ding",
"TJ Ley",
"DE Larson",
"BL Ebert",
"TL Lasho",
"CM Finke",
"CA Hanson",
"Y Kikushige",
"F Ishikawa",
"T Miyamoto",
"C Quivoron",
"L Couronne",
"V Della Valle",
"A Yokoi",
"Y Kotake",
"K Takahashi",
"D Rossi",
"A Bruscaggin",
"V Spina",
"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
|
N/A
|
N/A
|
fr
| 0.999996
| 2.887832
| 3.989543
| 3.063959
| 4.001479
| -0.00216
| 1.023546
| 0.002102
| 6.591528
| -2.886723
| 1.065666
| 0.626378
| 1.007055
| 0.027063
| 2.149005
|
medical_knowledge
| 0.970522
|
questions
| 0.996337
| 0
| 0.999288
| 1
| 0.999978
| 1
| 0.999805
|
0112B54A652D9818D8F6CBDFC132BBE045FD1133_p14
|
0112B54A652D9818D8F6CBDFC132BBE045FD1133
|
sec[1]/sec[1]/p[6]
|
Implication récurrente de gènes dont les produits participent à la biologie de l’ARN
| 3.527344
| -0.7368
|
biomedical
|
Study
|
[
0.9970703125,
0.00035881996154785156,
0.0025310516357421875
] |
[
0.81103515625,
0.1854248046875,
0.0028972625732421875,
0.0006604194641113281
] |
Ces données sont bien sûr très récentes, mais il est curieux de constater que plusieurs étapes de la biologie de l’ARN, maturation, transport, traduction et dégradation, semblent être ciblées dans les processus de transformation tumorale. Elles s’ajoutent à la description du rôle de la perte du gène RPS14 , codant pour une protéine ribosomique, dans la pathogenèse des SMD avec 5q- et un rôle potentiel des ARN non codants dans le contrôle de l’épissage .
|
[
"Frederik Damm",
"Florence Nguyen-Khac",
"Olivier Kosmider",
"Michaela Fontenay",
"Olivier A. Bernard",
"K Yoshida",
"M Sanada",
"Y Shiraishi",
"E Papaemmanuil",
"M Cazzola",
"J Boultwood",
"TA Graubert",
"D Shen",
"L Ding",
"MM Patnaik",
"TL Lasho",
"JM Hodnefield",
"F Damm",
"F Thol",
"O Kosmider",
"L Wang",
"MS Lawrence",
"Y Wan",
"V Quesada",
"L Conde",
"N Villamor",
"AA Ferrando",
"M Di Ianni",
"S Baldoni",
"E Rosati",
"G Fabbri",
"S Rasi",
"D Rossi",
"XS Puente",
"M Pinyol",
"V Quesada",
"E Hiriart",
"H Gruffat",
"M Buisson",
"S Xu",
"MA Powers",
"HR Christofk",
"MG Vander Heiden",
"MH Harris",
"M Gabut",
"P Samavarchi-Tehrani",
"X Wang",
"RF Luco",
"T Misteli",
"MA Chapman",
"MS Lawrence",
"JJ Keats",
"L Ding",
"TJ Ley",
"DE Larson",
"BL Ebert",
"TL Lasho",
"CM Finke",
"CA Hanson",
"Y Kikushige",
"F Ishikawa",
"T Miyamoto",
"C Quivoron",
"L Couronne",
"V Della Valle",
"A Yokoi",
"Y Kotake",
"K Takahashi",
"D Rossi",
"A Bruscaggin",
"V Spina",
"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
|
N/A
|
N/A
|
fr
| 0.999996
| 2.494435
| 3.939508
| 3.057401
| 4.023915
| -0.017063
| 1.01018
| 0.003926
| 6.352025
| -2.471814
| -0.314099
| 0.261719
| 0.836265
| 0.047918
| -1.68515
|
research_findings
| 0.486479
|
questions
| 0.997285
| 0
| 0.982557
| 1
| 0.999718
| 1
| 0.999828
|
0112B54A652D9818D8F6CBDFC132BBE045FD1133_p15
|
0112B54A652D9818D8F6CBDFC132BBE045FD1133
|
sec[1]/sec[2]/p[0]
|
Les mutations du gène SF3B1 sont fréquentes dans les LLC et les SMD
| 4.378906
| -0.238161
|
biomedical
|
Study
|
[
0.99853515625,
0.0003771781921386719,
0.00127410888671875
] |
[
0.9853515625,
0.0126495361328125,
0.0016021728515625,
0.0002486705780029297
] |
Le gène SF3B1 , qui code pour une protéine impliquée dans l’épissage, est muté dans 10 à 15 % des SMD et une proportion équivalente de LLC. L’identification d’un gène muté à la fois dans les SMD et les LLC est inattendue, tant ces deux pathologies sont considérées comme éloignées sur le plan physiopathologique. Les SMD sont considérées comme des maladies de la cellule souche, tandis que les LLC sont considérées comme résultant de la transformation de cellules engagées dans la différenciation lymphoïde de type B. Une explication évidente est que les mutations de SF3B1 ont les mêmes conséquences dans les deux types de cellules, et donc participent aussi bien à la transformation d’un lymphocyte B qu’à celle d’un progéniteur myéloïde. L’observation de mutations de SF3B1 dans d’autres tumeurs, incluant des syndromes myéloprolifératifs et des tumeurs solides, plaide en faveur de cette hypothèse . SF3B1 pourrait participer à l’activité des polycomb repressive complex .
|
[
"Frederik Damm",
"Florence Nguyen-Khac",
"Olivier Kosmider",
"Michaela Fontenay",
"Olivier A. Bernard",
"K Yoshida",
"M Sanada",
"Y Shiraishi",
"E Papaemmanuil",
"M Cazzola",
"J Boultwood",
"TA Graubert",
"D Shen",
"L Ding",
"MM Patnaik",
"TL Lasho",
"JM Hodnefield",
"F Damm",
"F Thol",
"O Kosmider",
"L Wang",
"MS Lawrence",
"Y Wan",
"V Quesada",
"L Conde",
"N Villamor",
"AA Ferrando",
"M Di Ianni",
"S Baldoni",
"E Rosati",
"G Fabbri",
"S Rasi",
"D Rossi",
"XS Puente",
"M Pinyol",
"V Quesada",
"E Hiriart",
"H Gruffat",
"M Buisson",
"S Xu",
"MA Powers",
"HR Christofk",
"MG Vander Heiden",
"MH Harris",
"M Gabut",
"P Samavarchi-Tehrani",
"X Wang",
"RF Luco",
"T Misteli",
"MA Chapman",
"MS Lawrence",
"JJ Keats",
"L Ding",
"TJ Ley",
"DE Larson",
"BL Ebert",
"TL Lasho",
"CM Finke",
"CA Hanson",
"Y Kikushige",
"F Ishikawa",
"T Miyamoto",
"C Quivoron",
"L Couronne",
"V Della Valle",
"A Yokoi",
"Y Kotake",
"K Takahashi",
"D Rossi",
"A Bruscaggin",
"V Spina",
"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
|
N/A
|
N/A
|
fr
| 0.999996
| 3.216154
| 4.009895
| 2.99379
| 3.965438
| -0.012588
| 1.021366
| 0.001164
| 5.307725
| -3.053584
| 1.390823
| 1.012985
| 1.031425
| -0.027042
| 1.663167
|
medical_knowledge
| 0.987889
|
questions
| 0.992529
| 0
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| 1
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|
0112B54A652D9818D8F6CBDFC132BBE045FD1133_p16
|
0112B54A652D9818D8F6CBDFC132BBE045FD1133
|
sec[1]/sec[2]/p[1]
|
Les mutations du gène SF3B1 sont fréquentes dans les LLC et les SMD
| 3.634766
| -1.39304
|
biomedical
|
Study
|
[
0.998046875,
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[
0.7060546875,
0.291015625,
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0.0009756088256835938
] |
Des données récentes indiquent que les LLC pourraient dériver d’anomalies des cellules souches hématopoïétiques . Un autre argument vient des études récentes du gène TET2 . Les mutations de TET2 peuvent être observées dans des hémopathies myéloïdes malignes et dans des hémopathies lymphoïdes matures, principalement lymphoïdes T. Dans ces deux cas, il est possible de mettre en évidence la présence de ces mutations dans les progéniteurs myéloïdes, suggérant également que ces pathologies pouvant avoir pour origine une cellule souche
|
[
"Frederik Damm",
"Florence Nguyen-Khac",
"Olivier Kosmider",
"Michaela Fontenay",
"Olivier A. Bernard",
"K Yoshida",
"M Sanada",
"Y Shiraishi",
"E Papaemmanuil",
"M Cazzola",
"J Boultwood",
"TA Graubert",
"D Shen",
"L Ding",
"MM Patnaik",
"TL Lasho",
"JM Hodnefield",
"F Damm",
"F Thol",
"O Kosmider",
"L Wang",
"MS Lawrence",
"Y Wan",
"V Quesada",
"L Conde",
"N Villamor",
"AA Ferrando",
"M Di Ianni",
"S Baldoni",
"E Rosati",
"G Fabbri",
"S Rasi",
"D Rossi",
"XS Puente",
"M Pinyol",
"V Quesada",
"E Hiriart",
"H Gruffat",
"M Buisson",
"S Xu",
"MA Powers",
"HR Christofk",
"MG Vander Heiden",
"MH Harris",
"M Gabut",
"P Samavarchi-Tehrani",
"X Wang",
"RF Luco",
"T Misteli",
"MA Chapman",
"MS Lawrence",
"JJ Keats",
"L Ding",
"TJ Ley",
"DE Larson",
"BL Ebert",
"TL Lasho",
"CM Finke",
"CA Hanson",
"Y Kikushige",
"F Ishikawa",
"T Miyamoto",
"C Quivoron",
"L Couronne",
"V Della Valle",
"A Yokoi",
"Y Kotake",
"K Takahashi",
"D Rossi",
"A Bruscaggin",
"V Spina",
"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
|
N/A
|
N/A
|
fr
| 0.999998
| 2.773344
| 3.934294
| 3.019259
| 3.943238
| -0.013962
| 1.001919
| 0.002056
| 4.529773
| -1.688113
| -1.123119
| 0.182841
| 0.912369
| -0.025497
| -0.547134
|
medical_knowledge
| 0.826873
|
questions
| 0.977288
| 0
| 0.972393
| 1
| 0.997422
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|
0112B54A652D9818D8F6CBDFC132BBE045FD1133_p17
|
0112B54A652D9818D8F6CBDFC132BBE045FD1133
|
sec[1]/sec[2]/p[2]
|
Les mutations du gène SF3B1 sont fréquentes dans les LLC et les SMD
| 3.537109
| -0.143477
|
biomedical
|
Other
|
[
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[
0.1690673828125,
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Une partie de ces données pourrait rapidement trouver une application clinique du fait d’un lien établi entre ces mutations, la présentation clinique au diagnostic et le pronostic. De plus, SF3B1 est déjà la cible d’agents thérapeutiques, tels que la splicéostatine A . Curieusement, les conséquences cellulaires de ces mutations semblent être néfastes pour la croissance cellulaire. La compréhension des mécanismes d’action de ces mutations est essentielle pour le développement de thérapies ciblées, mais nécessitera des analyses fonctionnelles plus poussées et le développement de modèles sophistiqués.
|
[
"Frederik Damm",
"Florence Nguyen-Khac",
"Olivier Kosmider",
"Michaela Fontenay",
"Olivier A. Bernard",
"K Yoshida",
"M Sanada",
"Y Shiraishi",
"E Papaemmanuil",
"M Cazzola",
"J Boultwood",
"TA Graubert",
"D Shen",
"L Ding",
"MM Patnaik",
"TL Lasho",
"JM Hodnefield",
"F Damm",
"F Thol",
"O Kosmider",
"L Wang",
"MS Lawrence",
"Y Wan",
"V Quesada",
"L Conde",
"N Villamor",
"AA Ferrando",
"M Di Ianni",
"S Baldoni",
"E Rosati",
"G Fabbri",
"S Rasi",
"D Rossi",
"XS Puente",
"M Pinyol",
"V Quesada",
"E Hiriart",
"H Gruffat",
"M Buisson",
"S Xu",
"MA Powers",
"HR Christofk",
"MG Vander Heiden",
"MH Harris",
"M Gabut",
"P Samavarchi-Tehrani",
"X Wang",
"RF Luco",
"T Misteli",
"MA Chapman",
"MS Lawrence",
"JJ Keats",
"L Ding",
"TJ Ley",
"DE Larson",
"BL Ebert",
"TL Lasho",
"CM Finke",
"CA Hanson",
"Y Kikushige",
"F Ishikawa",
"T Miyamoto",
"C Quivoron",
"L Couronne",
"V Della Valle",
"A Yokoi",
"Y Kotake",
"K Takahashi",
"D Rossi",
"A Bruscaggin",
"V Spina",
"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
|
N/A
|
N/A
|
fr
| 0.999997
| 2.628434
| 3.873434
| 2.97338
| 3.943648
| 0.011234
| 0.984188
| 0.002296
| 6.720134
| -2.639786
| -0.029904
| 0.042083
| 0.332698
| -0.010536
| -0.185041
|
medical_knowledge
| 0.884765
|
questions
| 0.990939
| 0
| 0.993597
| 1
| 0.999961
| 1
| 0.999833
|
0112B54A652D9818D8F6CBDFC132BBE045FD1133_p18
|
0112B54A652D9818D8F6CBDFC132BBE045FD1133
|
sec[2]/p[0]
|
Liens d’intérêt
| 1.072266
| -2.188749
|
other
|
Other
|
[
0.115478515625,
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[
0.0079193115234375,
0.990234375,
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Les auteurs déclarent n’avoir aucun lien d’intérêt concernant les données publiées dans cet article.
|
[
"Frederik Damm",
"Florence Nguyen-Khac",
"Olivier Kosmider",
"Michaela Fontenay",
"Olivier A. Bernard",
"K Yoshida",
"M Sanada",
"Y Shiraishi",
"E Papaemmanuil",
"M Cazzola",
"J Boultwood",
"TA Graubert",
"D Shen",
"L Ding",
"MM Patnaik",
"TL Lasho",
"JM Hodnefield",
"F Damm",
"F Thol",
"O Kosmider",
"L Wang",
"MS Lawrence",
"Y Wan",
"V Quesada",
"L Conde",
"N Villamor",
"AA Ferrando",
"M Di Ianni",
"S Baldoni",
"E Rosati",
"G Fabbri",
"S Rasi",
"D Rossi",
"XS Puente",
"M Pinyol",
"V Quesada",
"E Hiriart",
"H Gruffat",
"M Buisson",
"S Xu",
"MA Powers",
"HR Christofk",
"MG Vander Heiden",
"MH Harris",
"M Gabut",
"P Samavarchi-Tehrani",
"X Wang",
"RF Luco",
"T Misteli",
"MA Chapman",
"MS Lawrence",
"JJ Keats",
"L Ding",
"TJ Ley",
"DE Larson",
"BL Ebert",
"TL Lasho",
"CM Finke",
"CA Hanson",
"Y Kikushige",
"F Ishikawa",
"T Miyamoto",
"C Quivoron",
"L Couronne",
"V Della Valle",
"A Yokoi",
"Y Kotake",
"K Takahashi",
"D Rossi",
"A Bruscaggin",
"V Spina",
"OA Bernard",
"DG Gilliland",
"T Mercher",
"T Mercher",
"C Quivoron",
"L Couronné"
] |
https://doi.org/10.1051/medsci/2012285002
|
N/A
|
N/A
|
fr
| 0.999997
| 0.960112
| 4.978096
| 0.963496
| 0.925495
| 0.016377
| -0.003751
| 0.002131
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|
policy_administrative
| 0.973843
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questions
| 0.999817
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011DB975795A2F99BE9259140A301F1F20722D9A_p0
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[0]/p[0]
|
Abréviations
| 2.935547
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biomedical
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Other
|
[
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ADA Anti-Drug Antibodies BALT Bronchus-Associated Lymphoid Tissues CMH Complexe Majeur d’Histocompatibilité ELISA Enzyme-Linked ImmunoSorbent Assay EMA European Medicines Agency (Agence Européenne du Médicament) FDA Food and Drug Administration ICH International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (Conseil International d’Harmonisation des Exigences Techniques pour l’Enregistrement des Médicaments à Usage Humain) KLH Keyhole Limpet Hemocyanin LLNA Local Lymph Node Assay LLNP Local Lymph Node Proliferation LPS Lipopolysaccharide NALT Nasal-Associated Lymphoid Tissues NHP Primate non humain NOAE No Observed Adverse Effect Level OCDE Organisation de Coopération et de Développement Économiques OPPTS Office of Prevention, Pesticides and Toxic Substances PBMC Cellules mononuclées du sang périphérique PFC Plaque-Forming Cell Assay REACH Registration, Evaluation, Autorisation and Restriction of Chemicals SRBC Erythrocytes de mouton ( Sheep Red Blood Cells ) TDAR T-cell Dependent Antibody Response TIAR T-cell Independent Antibody Response TT Tetanus toxoid (anatoxine tétanique) US EPA US Environmental Protection Agency (Agence de Protection de l’Environnement des États-Unis)
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
"H. Van Loveren",
"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
"J.H. Dean",
"J.R. Hincks",
"B. Remandet",
"J. Descotes",
"J. Descotes",
"J. Descotes",
"P. Wexler",
"R.Z. Dintzis",
"B. Vogelstein",
"H.M. Dintzis",
"M.A. Dobrovolskaia",
"S.E. McNeil",
"S.A. Elmore",
"EMA",
"EMA",
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"R.M. Tighe",
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"E.A. Lefevre",
"B.V. Carr",
"H. Prentice",
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"B. Charleston",
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"D. Finco",
"M.M. Fort",
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"K. Harper",
"W.S. Helms",
"J.A. Mitchell",
"R. O’Lone",
"S.T. Parish",
"M.-S. Piche",
"D.M. Reed",
"G. Reichmann",
"P.C. Ryan",
"R. Stebbings",
"M. Walker",
"H.G. Haggerty",
"T. Hartung",
"E. Corsini",
"C.J. Janeway",
"P. Travers",
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"M.J. Shlomchik",
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"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
en
| 0.571426
| 1.358607
| 4.276995
| 2.127694
| 3.842298
| -0.076425
| 0.957271
| 0.005617
| -1.538072
| -4.59356
| 5.348031
| 0.190661
| 0.880584
| 0.959664
| 2.586613
|
other
| 0.67001
|
questions
| 0.999825
| 0
| 0.999131
| 1
| 0.999983
| 1
| 0.987809
|
011DB975795A2F99BE9259140A301F1F20722D9A_p1
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[1]/p[0]
|
Introduction
| 4.625
| -0.792516
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biomedical
|
Study
|
[
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[
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L’immunotoxicologie est l’étude du dysfonctionnement du système immunitaire induit par l’exposition à un xénobiotique chimique ou biologique. L’immunotoxicité peut se manifester par une immunosuppression, une immunostimulation, une allergie ou une réaction auto-immune ( Tableau 1 ) . C’est une branche relativement récente de l’évaluation toxicologique des xénobiotiques qui s’applique à divers produits qui peuvent impacter la santé humaine et animale : pharmaceutiques (médicaments, cosmétiques), agro-alimentaires (pesticides, additifs alimentaires), chimiques, environnementaux (métaux lourds, particules), professionnels (hydrocarbures aromatiques polycycliques), entre autres . Alors que des cas d’allergie et d’hypersensibilité à un produit étaient déjà documentés, notamment pour les pathologies respiratoires , les cas d’immunosuppression sont signalés depuis les années 1970 et c’est en 1977 qu’est publiée la première revue d’immunotoxicologie . À la suite de l’émergence des médicaments immunomodulateurs, le domaine de l’immunotoxicologie est apparu en 1983. Ces immunomodulateurs peuvent altérer le fonctionnement du système immunitaire et sont notamment utilisés dans la transplantation d’organe, la chimiothérapie et le traitement de maladies auto-immunes . Par ailleurs, de nombreux nouveaux traitements utilisent des molécules issues des biotechnologies comme les anticorps monoclonaux, les protéines recombinantes (cytokines, hormones, facteurs de croissance) ou les protéines de substitution (facteurs de coagulation, enzymes). En raison de leur taille plus importante que celle des molécules conventionnelles et du degré d’humanisation des anticorps, ces protéines peuvent présenter une immunogénicité et générer des anticorps dirigés contre ces médicaments, les ADA ( Anti-Drug Antibodies ). Ces ADA peuvent notamment diminuer l’efficacité du traitement ou mettre en danger le patient par une réponse auto-immune .
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
"H. Van Loveren",
"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
"J.H. Dean",
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"H. Geyer",
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"M.J. Shlomchik",
"P.W.F. Karmaus",
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"R. Kaul",
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"E.W. Evans",
"R. Kawai",
"S. Ito",
"T. Aida",
"H. Hattori",
"T. Kimura",
"T. Furukawa",
"K. Mori",
"A. Sanbuissho",
"T. Kawada",
"L.D. Koller",
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"J. van Bilsen",
"H. Cnossen",
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"J. Garthoff",
"A. Wolterbeek",
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"L. Cowan",
"M. Lagrou",
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"M.B. Neradilek",
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"H. Lebrec",
"B. Molinier",
"D. Boverhof",
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"D.Y. Logel",
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"A.M. Kaplan",
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"B.W. Neun",
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"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
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Bien que les méthodes analytiques en immunologie soient déjà développées et utilisées communément dans les laboratoires, dans les premiers temps de l’immunotoxicologie, l’absence de standardisation des plans d’étude expérimentaux rendait délicate la comparaison des résultats entre les différents laboratoires . Des lignes directrices ont été mises en place à partir de 1996 afin de répondre à cette problématique et aux exigences réglementaires découlant des référentiels de l’Organisation de Coopération et de Développement Économiques (OCDE) . L’OCDE propose des lignes directrices généralistes permettant de détecter des effets immunotoxiques de produits chimiques, comme par exemple OCDE 407 pour le rat et OCDE 409 pour les non rongeurs , qui ont été publiées en 1981. En 1995, elles ont été revues afin d’ajouter la mention de l’immunotoxicité. Les premières lignes directrices spécifiques concernaient les tests in vivo sur les rongeurs pour les pesticides, publiées par l’Agence de Protection de l’Environnement des États-Unis ( US Environmental Protection Agency , US EPA) en 1996 avec les lignes directrices OPPTS 880.3550 et OPPTS 870.7800 pour évaluer l’immunotoxicité et OPPTS 880.3800 pour évaluer la réponse immunitaire. L’OCDE a ensuite proposé en 2018 des lignes directrices plus spécifiques, avec OCDE 443 concernant les études de reprotoxicité et OCDE 406 « Sensibilisation de la peau » . Pour les médicaments à usage humain, la ligne directrice S8 a été rédigée par le Conseil International d’Harmonisation des Exigences Techniques pour l’Enregistrement des Médicaments à Usage Humain ( International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use , ICH). Les produits biotechnologiques ont leur procédure spécifique dans la ligne directrice S6 de l’ICH . Ces lignes directrices sont reprises notamment par les agences de santé européenne (Agence Européenne du Médicament ou European Medicines Agency , EMA) et américaine ( Food and Drug Administration , FDA), mais l’évaluation des effets allergisants ou auto-immuns n’y est pas décrite. Concernant les produits chimiques, le règlement REACH ( Registration, Evaluation, Autorisation and Restriction of Chemicals ) ne demande pas de réaliser des tests d’immunotoxicité en première intention. Cependant, le règlement REACH impose d’effectuer des études à doses répétées pour les essais d’immunotoxicologie à court (28 jours) ou à long terme (90 jours) .
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
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"G.R. Burleson",
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"R.W. Luebke",
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"J.H. Dean",
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] |
https://doi.org/10.1051/jbio/2022020
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Pour l’évaluation de l’immunotoxicité d’un nouveau médicament à usage humain, les laboratoires suivent depuis le 1 er mai 2006 la ligne directrice S8 établie par l’ICH. Celle-ci a pour but de permettre la détection d’un potentiel effet immunotoxique basée sur une évaluation à niveaux de preuves, puis l’exploration et l’affirmation de cet effet par des essais pertinents le cas échéant . Tous les nouveaux médicaments à usage humain doivent être évalués pour leur immunotoxicité en plus des études de toxicologie générale. Il est recommandé d’estimer cette immunotoxicité avant la phase III (développement clinique) pour une nouvelle molécule.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
"H. Van Loveren",
"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
"J.H. Dean",
"J.R. Hincks",
"B. Remandet",
"J. Descotes",
"J. Descotes",
"J. Descotes",
"P. Wexler",
"R.Z. Dintzis",
"B. Vogelstein",
"H.M. Dintzis",
"M.A. Dobrovolskaia",
"S.E. McNeil",
"S.A. Elmore",
"EMA",
"EMA",
"S.T. Espenschied",
"R.M. Tighe",
"K.M. Gowdy",
"J.T. Farmer",
"R.R. Dietert",
"A.S. Faqi",
"V. Galbiati",
"M. Mitjans",
"E. Corsini",
"D. Germolec",
"R. Luebke",
"A. Rooney",
"K. Shipkowski",
"R. Vandebriel",
"H. van Loveren",
"D.R. Germolec",
"K.A. Shipkowski",
"R.P. Frawley",
"E. Evans",
"H. Geyer",
"M. Wuhrer",
"A. Resemann",
"R. Geyer",
"C.F. Grant",
"E.A. Lefevre",
"B.V. Carr",
"H. Prentice",
"S. Gubbins",
"A.J. Pollard",
"C. Charreyre",
"B. Charleston",
"C. Grimaldi",
"D. Finco",
"M.M. Fort",
"D. Gliddon",
"K. Harper",
"W.S. Helms",
"J.A. Mitchell",
"R. O’Lone",
"S.T. Parish",
"M.-S. Piche",
"D.M. Reed",
"G. Reichmann",
"P.C. Ryan",
"R. Stebbings",
"M. Walker",
"H.G. Haggerty",
"T. Hartung",
"E. Corsini",
"C.J. Janeway",
"P. Travers",
"M. Walport",
"M.J. Shlomchik",
"P.W.F. Karmaus",
"A.L. Karmaus",
"R. Kaul",
"T.T. Kawabata",
"E.W. Evans",
"R. Kawai",
"S. Ito",
"T. Aida",
"H. Hattori",
"T. Kimura",
"T. Furukawa",
"K. Mori",
"A. Sanbuissho",
"T. Kawada",
"L.D. Koller",
"C.F. Kuper",
"J. van Bilsen",
"H. Cnossen",
"G. Houben",
"J. Garthoff",
"A. Wolterbeek",
"G.S. Ladics",
"H. Lebrec",
"L. Cowan",
"M. Lagrou",
"C. Krejsa",
"M.B. Neradilek",
"N.L. Polissar",
"L. Black",
"J. Bussière",
"H. Lebrec",
"B. Molinier",
"D. Boverhof",
"M. Collinge",
"W. Freebern",
"K. Henson",
"D.T. Mytych",
"H.D. Ochs",
"R. Wange",
"Y. Yang",
"L. Zhou",
"J. Arrington",
"M.S. Christin-Piché",
"J. Shenton",
"D.Y. Logel",
"P.R. Jaschke",
"S. Lorenzo-Herrero",
"C. Sordo-Bahamonde",
"S. González",
"A. López-Soto",
"M.I. Luster",
"S. Mahalingam",
"J. Peter",
"Z. Xu",
"D. Bordoloi",
"M. Ho",
"V.S. Kalyanaraman",
"A. Srinivasan",
"K. Muthumani",
"P.L. Martin",
"S. Meunier",
"M. de Bourayne",
"M. Hamze",
"A. Azam",
"E. Correia",
"C. Menier",
"B. Maillère",
"J.J. Mond",
"Q. Vos",
"A. Lees",
"C.M. Snapper",
"M. Nagarkatti",
"S.A. Rieder",
"P.S. Nagarkatti",
"OECD",
"OECD",
"OECD",
"OECD",
"M. Oellerich",
"G. Brandhorst",
"M. Shipkova",
"E. Wieland",
"A. Dasgupta",
"J.S. Orange",
"M. Ballow",
"E.R. Stiehm",
"Z.K. Ballas",
"J. Chinen",
"M. De La Morena",
"D. Kumararatne",
"T.O. Harville",
"P. Hesterberg",
"M. Koleilat",
"S. McGhee",
"E.E. Perez",
"J. Raasch",
"R. Scherzer",
"H. Schroeder",
"C. Seroogy",
"A. Huissoon",
"R.U. Sorensen",
"R. Katial",
"V.L. Peachee",
"M.J. Smith",
"M.J. Beck",
"D.G. Stump",
"K.L. White",
"L. Peyton Myers",
"L.M. Plitnick",
"D.J. Herzyk",
"L.M. Plunkett",
"A.M. Kaplan",
"R.A. Becker",
"T.M. Potter",
"B.W. Neun",
"M.A. Dobrovolskaia",
"T. Rabadi",
"M.F. Brady",
"L. Richards",
"B. Erko",
"K. Ponpetch",
"S.J. Ryan",
"S. Liang",
"A.N. Rumianek",
"D.R. Greaves",
"ScienceDirect",
"R. Sharon",
"P.R. McMaster",
"A.M. Kask",
"J.D. Owens",
"W.E. Paul",
"L. Taylor",
"C. Recio",
"D.R. Greaves",
"A.J. Iqbal",
"The European Commission",
"Thériaque",
"Thériaque",
"Thériaque",
"US EPA",
"US EPA",
"US EPA",
"J.G. Vos",
"J.A. Moore",
"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999996
| 2.344409
| 4.013764
| 2.878474
| 3.716818
| 0.012382
| 0.969321
| -0.001181
| 0.128032
| -5.472437
| 6.563108
| 1.002685
| 0.904485
| -0.049813
| 2.932632
|
policy_administrative
| 0.969237
|
questions
| 0.99962
| 0
| 0.99554
| 1
| 0.999992
| 1
| 0.999757
|
011DB975795A2F99BE9259140A301F1F20722D9A_p4
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[2]/p[1]
|
Essais d’immunotoxicité pour les médicaments à usage humain
| 1.837891
| -1.519619
|
biomedical
|
Other
|
[
0.96728515625,
0.0029201507568359375,
0.0299530029296875
] |
[
0.05718994140625,
0.93896484375,
0.0024967193603515625,
0.0012407302856445312
] |
Cette évaluation du potentiel immunotoxique d’un médicament à usage humain se fait par une approche à deux paliers :
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
"H. Van Loveren",
"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
"J.H. Dean",
"J.R. Hincks",
"B. Remandet",
"J. Descotes",
"J. Descotes",
"J. Descotes",
"P. Wexler",
"R.Z. Dintzis",
"B. Vogelstein",
"H.M. Dintzis",
"M.A. Dobrovolskaia",
"S.E. McNeil",
"S.A. Elmore",
"EMA",
"EMA",
"S.T. Espenschied",
"R.M. Tighe",
"K.M. Gowdy",
"J.T. Farmer",
"R.R. Dietert",
"A.S. Faqi",
"V. Galbiati",
"M. Mitjans",
"E. Corsini",
"D. Germolec",
"R. Luebke",
"A. Rooney",
"K. Shipkowski",
"R. Vandebriel",
"H. van Loveren",
"D.R. Germolec",
"K.A. Shipkowski",
"R.P. Frawley",
"E. Evans",
"H. Geyer",
"M. Wuhrer",
"A. Resemann",
"R. Geyer",
"C.F. Grant",
"E.A. Lefevre",
"B.V. Carr",
"H. Prentice",
"S. Gubbins",
"A.J. Pollard",
"C. Charreyre",
"B. Charleston",
"C. Grimaldi",
"D. Finco",
"M.M. Fort",
"D. Gliddon",
"K. Harper",
"W.S. Helms",
"J.A. Mitchell",
"R. O’Lone",
"S.T. Parish",
"M.-S. Piche",
"D.M. Reed",
"G. Reichmann",
"P.C. Ryan",
"R. Stebbings",
"M. Walker",
"H.G. Haggerty",
"T. Hartung",
"E. Corsini",
"C.J. Janeway",
"P. Travers",
"M. Walport",
"M.J. Shlomchik",
"P.W.F. Karmaus",
"A.L. Karmaus",
"R. Kaul",
"T.T. Kawabata",
"E.W. Evans",
"R. Kawai",
"S. Ito",
"T. Aida",
"H. Hattori",
"T. Kimura",
"T. Furukawa",
"K. Mori",
"A. Sanbuissho",
"T. Kawada",
"L.D. Koller",
"C.F. Kuper",
"J. van Bilsen",
"H. Cnossen",
"G. Houben",
"J. Garthoff",
"A. Wolterbeek",
"G.S. Ladics",
"H. Lebrec",
"L. Cowan",
"M. Lagrou",
"C. Krejsa",
"M.B. Neradilek",
"N.L. Polissar",
"L. Black",
"J. Bussière",
"H. Lebrec",
"B. Molinier",
"D. Boverhof",
"M. Collinge",
"W. Freebern",
"K. Henson",
"D.T. Mytych",
"H.D. Ochs",
"R. Wange",
"Y. Yang",
"L. Zhou",
"J. Arrington",
"M.S. Christin-Piché",
"J. Shenton",
"D.Y. Logel",
"P.R. Jaschke",
"S. Lorenzo-Herrero",
"C. Sordo-Bahamonde",
"S. González",
"A. López-Soto",
"M.I. Luster",
"S. Mahalingam",
"J. Peter",
"Z. Xu",
"D. Bordoloi",
"M. Ho",
"V.S. Kalyanaraman",
"A. Srinivasan",
"K. Muthumani",
"P.L. Martin",
"S. Meunier",
"M. de Bourayne",
"M. Hamze",
"A. Azam",
"E. Correia",
"C. Menier",
"B. Maillère",
"J.J. Mond",
"Q. Vos",
"A. Lees",
"C.M. Snapper",
"M. Nagarkatti",
"S.A. Rieder",
"P.S. Nagarkatti",
"OECD",
"OECD",
"OECD",
"OECD",
"M. Oellerich",
"G. Brandhorst",
"M. Shipkova",
"E. Wieland",
"A. Dasgupta",
"J.S. Orange",
"M. Ballow",
"E.R. Stiehm",
"Z.K. Ballas",
"J. Chinen",
"M. De La Morena",
"D. Kumararatne",
"T.O. Harville",
"P. Hesterberg",
"M. Koleilat",
"S. McGhee",
"E.E. Perez",
"J. Raasch",
"R. Scherzer",
"H. Schroeder",
"C. Seroogy",
"A. Huissoon",
"R.U. Sorensen",
"R. Katial",
"V.L. Peachee",
"M.J. Smith",
"M.J. Beck",
"D.G. Stump",
"K.L. White",
"L. Peyton Myers",
"L.M. Plitnick",
"D.J. Herzyk",
"L.M. Plunkett",
"A.M. Kaplan",
"R.A. Becker",
"T.M. Potter",
"B.W. Neun",
"M.A. Dobrovolskaia",
"T. Rabadi",
"M.F. Brady",
"L. Richards",
"B. Erko",
"K. Ponpetch",
"S.J. Ryan",
"S. Liang",
"A.N. Rumianek",
"D.R. Greaves",
"ScienceDirect",
"R. Sharon",
"P.R. McMaster",
"A.M. Kask",
"J.D. Owens",
"W.E. Paul",
"L. Taylor",
"C. Recio",
"D.R. Greaves",
"A.J. Iqbal",
"The European Commission",
"Thériaque",
"Thériaque",
"Thériaque",
"US EPA",
"US EPA",
"US EPA",
"J.G. Vos",
"J.A. Moore",
"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999998
| 2.072062
| 4.290322
| 1.864023
| 3.379903
| -0.006256
| 0.909178
| -0.003678
| 3.111414
| -6.965605
| 6.179606
| 0.262292
| 0.06043
| 0.026304
| 4.269925
|
medical_knowledge
| 0.879707
|
questions
| 0.999716
| 0
| 0.999629
| 1
| 0.999987
| 1
| 0.630806
|
011DB975795A2F99BE9259140A301F1F20722D9A_p5
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[2]/p[2]
|
Essais d’immunotoxicité pour les médicaments à usage humain
| 3.705078
| -1.17153
|
biomedical
|
Study
|
[
0.9970703125,
0.0007839202880859375,
0.0022716522216796875
] |
[
0.7685546875,
0.2294921875,
0.0011806488037109375,
0.0005950927734375
] |
Le premier palier doit permettre la détection d’un effet potentiellement immunotoxique de la molécule en utilisant des tests observationnels cliniques et biologiques souvent inclus dans le développement préclinique et clinique du médicament ( Tableau 2 ). Le second palier est effectué si un effet immunotoxique est détecté, d’abord pour le confirmer puis pour l’explorer afin de décrire le mécanisme lié à l’immunotoxicité, notamment par des tests fonctionnels.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
"H. Van Loveren",
"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
"J.H. Dean",
"J.R. Hincks",
"B. Remandet",
"J. Descotes",
"J. Descotes",
"J. Descotes",
"P. Wexler",
"R.Z. Dintzis",
"B. Vogelstein",
"H.M. Dintzis",
"M.A. Dobrovolskaia",
"S.E. McNeil",
"S.A. Elmore",
"EMA",
"EMA",
"S.T. Espenschied",
"R.M. Tighe",
"K.M. Gowdy",
"J.T. Farmer",
"R.R. Dietert",
"A.S. Faqi",
"V. Galbiati",
"M. Mitjans",
"E. Corsini",
"D. Germolec",
"R. Luebke",
"A. Rooney",
"K. Shipkowski",
"R. Vandebriel",
"H. van Loveren",
"D.R. Germolec",
"K.A. Shipkowski",
"R.P. Frawley",
"E. Evans",
"H. Geyer",
"M. Wuhrer",
"A. Resemann",
"R. Geyer",
"C.F. Grant",
"E.A. Lefevre",
"B.V. Carr",
"H. Prentice",
"S. Gubbins",
"A.J. Pollard",
"C. Charreyre",
"B. Charleston",
"C. Grimaldi",
"D. Finco",
"M.M. Fort",
"D. Gliddon",
"K. Harper",
"W.S. Helms",
"J.A. Mitchell",
"R. O’Lone",
"S.T. Parish",
"M.-S. Piche",
"D.M. Reed",
"G. Reichmann",
"P.C. Ryan",
"R. Stebbings",
"M. Walker",
"H.G. Haggerty",
"T. Hartung",
"E. Corsini",
"C.J. Janeway",
"P. Travers",
"M. Walport",
"M.J. Shlomchik",
"P.W.F. Karmaus",
"A.L. Karmaus",
"R. Kaul",
"T.T. Kawabata",
"E.W. Evans",
"R. Kawai",
"S. Ito",
"T. Aida",
"H. Hattori",
"T. Kimura",
"T. Furukawa",
"K. Mori",
"A. Sanbuissho",
"T. Kawada",
"L.D. Koller",
"C.F. Kuper",
"J. van Bilsen",
"H. Cnossen",
"G. Houben",
"J. Garthoff",
"A. Wolterbeek",
"G.S. Ladics",
"H. Lebrec",
"L. Cowan",
"M. Lagrou",
"C. Krejsa",
"M.B. Neradilek",
"N.L. Polissar",
"L. Black",
"J. Bussière",
"H. Lebrec",
"B. Molinier",
"D. Boverhof",
"M. Collinge",
"W. Freebern",
"K. Henson",
"D.T. Mytych",
"H.D. Ochs",
"R. Wange",
"Y. Yang",
"L. Zhou",
"J. Arrington",
"M.S. Christin-Piché",
"J. Shenton",
"D.Y. Logel",
"P.R. Jaschke",
"S. Lorenzo-Herrero",
"C. Sordo-Bahamonde",
"S. González",
"A. López-Soto",
"M.I. Luster",
"S. Mahalingam",
"J. Peter",
"Z. Xu",
"D. Bordoloi",
"M. Ho",
"V.S. Kalyanaraman",
"A. Srinivasan",
"K. Muthumani",
"P.L. Martin",
"S. Meunier",
"M. de Bourayne",
"M. Hamze",
"A. Azam",
"E. Correia",
"C. Menier",
"B. Maillère",
"J.J. Mond",
"Q. Vos",
"A. Lees",
"C.M. Snapper",
"M. Nagarkatti",
"S.A. Rieder",
"P.S. Nagarkatti",
"OECD",
"OECD",
"OECD",
"OECD",
"M. Oellerich",
"G. Brandhorst",
"M. Shipkova",
"E. Wieland",
"A. Dasgupta",
"J.S. Orange",
"M. Ballow",
"E.R. Stiehm",
"Z.K. Ballas",
"J. Chinen",
"M. De La Morena",
"D. Kumararatne",
"T.O. Harville",
"P. Hesterberg",
"M. Koleilat",
"S. McGhee",
"E.E. Perez",
"J. Raasch",
"R. Scherzer",
"H. Schroeder",
"C. Seroogy",
"A. Huissoon",
"R.U. Sorensen",
"R. Katial",
"V.L. Peachee",
"M.J. Smith",
"M.J. Beck",
"D.G. Stump",
"K.L. White",
"L. Peyton Myers",
"L.M. Plitnick",
"D.J. Herzyk",
"L.M. Plunkett",
"A.M. Kaplan",
"R.A. Becker",
"T.M. Potter",
"B.W. Neun",
"M.A. Dobrovolskaia",
"T. Rabadi",
"M.F. Brady",
"L. Richards",
"B. Erko",
"K. Ponpetch",
"S.J. Ryan",
"S. Liang",
"A.N. Rumianek",
"D.R. Greaves",
"ScienceDirect",
"R. Sharon",
"P.R. McMaster",
"A.M. Kask",
"J.D. Owens",
"W.E. Paul",
"L. Taylor",
"C. Recio",
"D.R. Greaves",
"A.J. Iqbal",
"The European Commission",
"Thériaque",
"Thériaque",
"Thériaque",
"US EPA",
"US EPA",
"US EPA",
"J.G. Vos",
"J.A. Moore",
"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999995
| 2.728674
| 3.979336
| 2.965311
| 3.927375
| -0.009496
| 0.932053
| -0.002927
| 1.815129
| -6.358681
| 5.906456
| 0.870866
| -0.013642
| 0.000702
| 3.645789
|
medical_knowledge
| 0.769661
|
questions
| 0.999871
| 0
| 0.998225
| 1
| 0.99998
| 1
| 0.999671
|
011DB975795A2F99BE9259140A301F1F20722D9A_p6
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[2]/p[3]
|
Essais d’immunotoxicité pour les médicaments à usage humain
| 4.199219
| -0.175745
|
biomedical
|
Study
|
[
0.99853515625,
0.0004017353057861328,
0.000827789306640625
] |
[
0.99853515625,
0.0009431838989257812,
0.0006074905395507812,
0.000058650970458984375
] |
Pour le premier palier, les paramètres ou marqueurs peuvent être (i) identifiés lors d’études de toxicologie générale, sur la base des propriétés pharmacologiques, pharmacocinétiques et physicochimiques du principe actif, et (ii) associés à une population ciblée particulière (immunodéprimés) ou à des conditions d’administrations particulières ou encore d’après des données cliniques ( Tableau 2 ). En plus de la présence ou non de ces marqueurs, il est également important de prendre en compte la significativité statistique des résultats, la sévérité des effets, les doses et durées d’exposition pour lesquelles il y a eu un effet, le nombre d’espèces atteintes, la réversibilité des effets, les facteurs de stress associés à l’étude, ainsi que les cellules atteintes et le mécanisme de l’effet toxique observé. L’évaluation de ces marqueurs d’immunotoxicité permet la mise en place ou non d’une étude proprement dite de l’immunotoxicité de la molécule. La présence d’un seul marqueur d’intensité suffisante peut justifier les études d’immunotoxicité. Si cette évaluation n’est pas réalisée, elle doit être justifiée par l’entreprise qui développe la molécule.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
"H. Van Loveren",
"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
"J.H. Dean",
"J.R. Hincks",
"B. Remandet",
"J. Descotes",
"J. Descotes",
"J. Descotes",
"P. Wexler",
"R.Z. Dintzis",
"B. Vogelstein",
"H.M. Dintzis",
"M.A. Dobrovolskaia",
"S.E. McNeil",
"S.A. Elmore",
"EMA",
"EMA",
"S.T. Espenschied",
"R.M. Tighe",
"K.M. Gowdy",
"J.T. Farmer",
"R.R. Dietert",
"A.S. Faqi",
"V. Galbiati",
"M. Mitjans",
"E. Corsini",
"D. Germolec",
"R. Luebke",
"A. Rooney",
"K. Shipkowski",
"R. Vandebriel",
"H. van Loveren",
"D.R. Germolec",
"K.A. Shipkowski",
"R.P. Frawley",
"E. Evans",
"H. Geyer",
"M. Wuhrer",
"A. Resemann",
"R. Geyer",
"C.F. Grant",
"E.A. Lefevre",
"B.V. Carr",
"H. Prentice",
"S. Gubbins",
"A.J. Pollard",
"C. Charreyre",
"B. Charleston",
"C. Grimaldi",
"D. Finco",
"M.M. Fort",
"D. Gliddon",
"K. Harper",
"W.S. Helms",
"J.A. Mitchell",
"R. O’Lone",
"S.T. Parish",
"M.-S. Piche",
"D.M. Reed",
"G. Reichmann",
"P.C. Ryan",
"R. Stebbings",
"M. Walker",
"H.G. Haggerty",
"T. Hartung",
"E. Corsini",
"C.J. Janeway",
"P. Travers",
"M. Walport",
"M.J. Shlomchik",
"P.W.F. Karmaus",
"A.L. Karmaus",
"R. Kaul",
"T.T. Kawabata",
"E.W. Evans",
"R. Kawai",
"S. Ito",
"T. Aida",
"H. Hattori",
"T. Kimura",
"T. Furukawa",
"K. Mori",
"A. Sanbuissho",
"T. Kawada",
"L.D. Koller",
"C.F. Kuper",
"J. van Bilsen",
"H. Cnossen",
"G. Houben",
"J. Garthoff",
"A. Wolterbeek",
"G.S. Ladics",
"H. Lebrec",
"L. Cowan",
"M. Lagrou",
"C. Krejsa",
"M.B. Neradilek",
"N.L. Polissar",
"L. Black",
"J. Bussière",
"H. Lebrec",
"B. Molinier",
"D. Boverhof",
"M. Collinge",
"W. Freebern",
"K. Henson",
"D.T. Mytych",
"H.D. Ochs",
"R. Wange",
"Y. Yang",
"L. Zhou",
"J. Arrington",
"M.S. Christin-Piché",
"J. Shenton",
"D.Y. Logel",
"P.R. Jaschke",
"S. Lorenzo-Herrero",
"C. Sordo-Bahamonde",
"S. González",
"A. López-Soto",
"M.I. Luster",
"S. Mahalingam",
"J. Peter",
"Z. Xu",
"D. Bordoloi",
"M. Ho",
"V.S. Kalyanaraman",
"A. Srinivasan",
"K. Muthumani",
"P.L. Martin",
"S. Meunier",
"M. de Bourayne",
"M. Hamze",
"A. Azam",
"E. Correia",
"C. Menier",
"B. Maillère",
"J.J. Mond",
"Q. Vos",
"A. Lees",
"C.M. Snapper",
"M. Nagarkatti",
"S.A. Rieder",
"P.S. Nagarkatti",
"OECD",
"OECD",
"OECD",
"OECD",
"M. Oellerich",
"G. Brandhorst",
"M. Shipkova",
"E. Wieland",
"A. Dasgupta",
"J.S. Orange",
"M. Ballow",
"E.R. Stiehm",
"Z.K. Ballas",
"J. Chinen",
"M. De La Morena",
"D. Kumararatne",
"T.O. Harville",
"P. Hesterberg",
"M. Koleilat",
"S. McGhee",
"E.E. Perez",
"J. Raasch",
"R. Scherzer",
"H. Schroeder",
"C. Seroogy",
"A. Huissoon",
"R.U. Sorensen",
"R. Katial",
"V.L. Peachee",
"M.J. Smith",
"M.J. Beck",
"D.G. Stump",
"K.L. White",
"L. Peyton Myers",
"L.M. Plitnick",
"D.J. Herzyk",
"L.M. Plunkett",
"A.M. Kaplan",
"R.A. Becker",
"T.M. Potter",
"B.W. Neun",
"M.A. Dobrovolskaia",
"T. Rabadi",
"M.F. Brady",
"L. Richards",
"B. Erko",
"K. Ponpetch",
"S.J. Ryan",
"S. Liang",
"A.N. Rumianek",
"D.R. Greaves",
"ScienceDirect",
"R. Sharon",
"P.R. McMaster",
"A.M. Kask",
"J.D. Owens",
"W.E. Paul",
"L. Taylor",
"C. Recio",
"D.R. Greaves",
"A.J. Iqbal",
"The European Commission",
"Thériaque",
"Thériaque",
"Thériaque",
"US EPA",
"US EPA",
"US EPA",
"J.G. Vos",
"J.A. Moore",
"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999996
| 2.77883
| 3.967563
| 2.983932
| 3.954561
| -0.002685
| 0.98141
| -0.002075
| 4.969723
| -6.82471
| 6.140394
| 0.898369
| 0.035474
| 0.664138
| 3.819783
|
medical_knowledge
| 0.986549
|
questions
| 0.999829
| 0
| 0.999975
| 1
| 0.999998
| 1
| 0.999736
|
011DB975795A2F99BE9259140A301F1F20722D9A_p7
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[2]/p[4]
|
Essais d’immunotoxicité pour les médicaments à usage humain
| 2.511719
| -2.484437
|
biomedical
|
Other
|
[
0.98828125,
0.0016374588012695312,
0.01031494140625
] |
[
0.12017822265625,
0.8779296875,
0.001132965087890625,
0.000896453857421875
] |
Le plan d’étude d’évaluation de l’immunotoxicité doit, selon la ligne directrice ICH S8, prendre en compte les doses, la durée d’exposition, la voie d’administration et l’espèce utilisée.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
"H. Van Loveren",
"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
"J.H. Dean",
"J.R. Hincks",
"B. Remandet",
"J. Descotes",
"J. Descotes",
"J. Descotes",
"P. Wexler",
"R.Z. Dintzis",
"B. Vogelstein",
"H.M. Dintzis",
"M.A. Dobrovolskaia",
"S.E. McNeil",
"S.A. Elmore",
"EMA",
"EMA",
"S.T. Espenschied",
"R.M. Tighe",
"K.M. Gowdy",
"J.T. Farmer",
"R.R. Dietert",
"A.S. Faqi",
"V. Galbiati",
"M. Mitjans",
"E. Corsini",
"D. Germolec",
"R. Luebke",
"A. Rooney",
"K. Shipkowski",
"R. Vandebriel",
"H. van Loveren",
"D.R. Germolec",
"K.A. Shipkowski",
"R.P. Frawley",
"E. Evans",
"H. Geyer",
"M. Wuhrer",
"A. Resemann",
"R. Geyer",
"C.F. Grant",
"E.A. Lefevre",
"B.V. Carr",
"H. Prentice",
"S. Gubbins",
"A.J. Pollard",
"C. Charreyre",
"B. Charleston",
"C. Grimaldi",
"D. Finco",
"M.M. Fort",
"D. Gliddon",
"K. Harper",
"W.S. Helms",
"J.A. Mitchell",
"R. O’Lone",
"S.T. Parish",
"M.-S. Piche",
"D.M. Reed",
"G. Reichmann",
"P.C. Ryan",
"R. Stebbings",
"M. Walker",
"H.G. Haggerty",
"T. Hartung",
"E. Corsini",
"C.J. Janeway",
"P. Travers",
"M. Walport",
"M.J. Shlomchik",
"P.W.F. Karmaus",
"A.L. Karmaus",
"R. Kaul",
"T.T. Kawabata",
"E.W. Evans",
"R. Kawai",
"S. Ito",
"T. Aida",
"H. Hattori",
"T. Kimura",
"T. Furukawa",
"K. Mori",
"A. Sanbuissho",
"T. Kawada",
"L.D. Koller",
"C.F. Kuper",
"J. van Bilsen",
"H. Cnossen",
"G. Houben",
"J. Garthoff",
"A. Wolterbeek",
"G.S. Ladics",
"H. Lebrec",
"L. Cowan",
"M. Lagrou",
"C. Krejsa",
"M.B. Neradilek",
"N.L. Polissar",
"L. Black",
"J. Bussière",
"H. Lebrec",
"B. Molinier",
"D. Boverhof",
"M. Collinge",
"W. Freebern",
"K. Henson",
"D.T. Mytych",
"H.D. Ochs",
"R. Wange",
"Y. Yang",
"L. Zhou",
"J. Arrington",
"M.S. Christin-Piché",
"J. Shenton",
"D.Y. Logel",
"P.R. Jaschke",
"S. Lorenzo-Herrero",
"C. Sordo-Bahamonde",
"S. González",
"A. López-Soto",
"M.I. Luster",
"S. Mahalingam",
"J. Peter",
"Z. Xu",
"D. Bordoloi",
"M. Ho",
"V.S. Kalyanaraman",
"A. Srinivasan",
"K. Muthumani",
"P.L. Martin",
"S. Meunier",
"M. de Bourayne",
"M. Hamze",
"A. Azam",
"E. Correia",
"C. Menier",
"B. Maillère",
"J.J. Mond",
"Q. Vos",
"A. Lees",
"C.M. Snapper",
"M. Nagarkatti",
"S.A. Rieder",
"P.S. Nagarkatti",
"OECD",
"OECD",
"OECD",
"OECD",
"M. Oellerich",
"G. Brandhorst",
"M. Shipkova",
"E. Wieland",
"A. Dasgupta",
"J.S. Orange",
"M. Ballow",
"E.R. Stiehm",
"Z.K. Ballas",
"J. Chinen",
"M. De La Morena",
"D. Kumararatne",
"T.O. Harville",
"P. Hesterberg",
"M. Koleilat",
"S. McGhee",
"E.E. Perez",
"J. Raasch",
"R. Scherzer",
"H. Schroeder",
"C. Seroogy",
"A. Huissoon",
"R.U. Sorensen",
"R. Katial",
"V.L. Peachee",
"M.J. Smith",
"M.J. Beck",
"D.G. Stump",
"K.L. White",
"L. Peyton Myers",
"L.M. Plitnick",
"D.J. Herzyk",
"L.M. Plunkett",
"A.M. Kaplan",
"R.A. Becker",
"T.M. Potter",
"B.W. Neun",
"M.A. Dobrovolskaia",
"T. Rabadi",
"M.F. Brady",
"L. Richards",
"B. Erko",
"K. Ponpetch",
"S.J. Ryan",
"S. Liang",
"A.N. Rumianek",
"D.R. Greaves",
"ScienceDirect",
"R. Sharon",
"P.R. McMaster",
"A.M. Kask",
"J.D. Owens",
"W.E. Paul",
"L. Taylor",
"C. Recio",
"D.R. Greaves",
"A.J. Iqbal",
"The European Commission",
"Thériaque",
"Thériaque",
"Thériaque",
"US EPA",
"US EPA",
"US EPA",
"J.G. Vos",
"J.A. Moore",
"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999996
| 1.933419
| 3.982543
| 2.048061
| 3.391403
| -0.018408
| 0.976534
| -0.002543
| -0.772331
| -3.361513
| 5.566404
| 0.24144
| 0.818334
| 0.160493
| 4.002243
|
clinical_guidance
| 0.574719
|
questions
| 0.999668
| 4
| 0.526558
| 1
| 0.999544
| 1
| 0.998509
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011DB975795A2F99BE9259140A301F1F20722D9A_p8
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[2]/p[5]
|
Essais d’immunotoxicité pour les médicaments à usage humain
| 4.117188
| -0.072865
|
biomedical
|
Study
|
[
0.9970703125,
0.0003864765167236328,
0.0023040771484375
] |
[
0.88671875,
0.1041259765625,
0.00890350341796875,
0.0003840923309326172
] |
Le choix de l’espèce repose sur la capacité de la molécule à être pharmacologiquement active chez l’animal. Ce choix est donc basé sur le degré d’homologie de la cible (récepteur, épitope) entre l’animal et l’homme, l’affinité de liaison, les similitudes pharmacocinétiques et les données obtenues lors d’études précliniques de toxicologie générale. Les espèces utilisées dans les études d’immunotoxicologie sont les rongeurs (souris, rat), le lapin, le miniporc, le chien et les primates non humains (singes cynomolgus et rhésus) . La souris est souvent utilisée pour réaliser des études d’immunologie fondamentale car son génotype et sa réponse immunitaire générale sont connus . Les primates non humains sont de plus de plus inclus dans les études avec l’avènement des biotechnologies (protéines recombinantes ou de substitution, anticorps monoclonaux). Par exemple, le choix du singe cynomolgus ( Macaca fasciularis ) dont la génétique et la physiologie sont proches de celles de l’Homme, notamment en immunologie, en endocrinologie et en neurologie, permet de mieux prédire les risques toxicologiques chez l’Homme. Il est par ailleurs recommandé d’évaluer l’immunotoxicité chez les deux sexes .
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
"H. Van Loveren",
"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
"J.H. Dean",
"J.R. Hincks",
"B. Remandet",
"J. Descotes",
"J. Descotes",
"J. Descotes",
"P. Wexler",
"R.Z. Dintzis",
"B. Vogelstein",
"H.M. Dintzis",
"M.A. Dobrovolskaia",
"S.E. McNeil",
"S.A. Elmore",
"EMA",
"EMA",
"S.T. Espenschied",
"R.M. Tighe",
"K.M. Gowdy",
"J.T. Farmer",
"R.R. Dietert",
"A.S. Faqi",
"V. Galbiati",
"M. Mitjans",
"E. Corsini",
"D. Germolec",
"R. Luebke",
"A. Rooney",
"K. Shipkowski",
"R. Vandebriel",
"H. van Loveren",
"D.R. Germolec",
"K.A. Shipkowski",
"R.P. Frawley",
"E. Evans",
"H. Geyer",
"M. Wuhrer",
"A. Resemann",
"R. Geyer",
"C.F. Grant",
"E.A. Lefevre",
"B.V. Carr",
"H. Prentice",
"S. Gubbins",
"A.J. Pollard",
"C. Charreyre",
"B. Charleston",
"C. Grimaldi",
"D. Finco",
"M.M. Fort",
"D. Gliddon",
"K. Harper",
"W.S. Helms",
"J.A. Mitchell",
"R. O’Lone",
"S.T. Parish",
"M.-S. Piche",
"D.M. Reed",
"G. Reichmann",
"P.C. Ryan",
"R. Stebbings",
"M. Walker",
"H.G. Haggerty",
"T. Hartung",
"E. Corsini",
"C.J. Janeway",
"P. Travers",
"M. Walport",
"M.J. Shlomchik",
"P.W.F. Karmaus",
"A.L. Karmaus",
"R. Kaul",
"T.T. Kawabata",
"E.W. Evans",
"R. Kawai",
"S. Ito",
"T. Aida",
"H. Hattori",
"T. Kimura",
"T. Furukawa",
"K. Mori",
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"US EPA",
"US EPA",
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"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
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| 0.999995
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011DB975795A2F99BE9259140A301F1F20722D9A_p9
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[2]/p[6]
|
Essais d’immunotoxicité pour les médicaments à usage humain
| 3.361328
| -3.599121
|
biomedical
|
Other
|
[
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[
0.232666015625,
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La dose sélectionnée doit être suffisamment élevée et supérieure à la NOAEL ( No Observed Adverse Effect Level ), tout en évitant de générer une toxicité systémique liée par exemple au stress . Il est recommandé d’évaluer plusieurs doses sur un schéma répété afin de déterminer l’existence ou non d’un effet-dose ainsi que la dose pharmacologiquement active la plus élevée sans effets immunologiques. Concernant la voie d’administration, il est recommandé d’utiliser la même que celle qui sera utilisée chez l’Homme.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
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"J.W. van der Laan",
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"H. Van Loveren",
"J.H. Dean",
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"R. Kaul",
"T.T. Kawabata",
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"T. Kimura",
"T. Furukawa",
"K. Mori",
"A. Sanbuissho",
"T. Kawada",
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"C.F. Kuper",
"J. van Bilsen",
"H. Cnossen",
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"J.S. Orange",
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"E.R. Stiehm",
"Z.K. Ballas",
"J. Chinen",
"M. De La Morena",
"D. Kumararatne",
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"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
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011DB975795A2F99BE9259140A301F1F20722D9A_p10
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011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[2]/p[7]
|
Essais d’immunotoxicité pour les médicaments à usage humain
| 3.71875
| -0.43858
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biomedical
|
Study
|
[
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[
0.75439453125,
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La durée d’exposition à la molécule à tester doit être suffisamment longue pour suivre la cinétique des marqueurs de modifications du système immunitaire. Pour une étude s’intéressant à la réponse humorale en utilisant le test TDAR (voir plus loin), ces marqueurs sont les immunoglobulines M (IgM) et G (IgG). Afin de couvrir la demi-vie de ces immunoglobulines, il est nécessaire de réaliser une étude ayant une durée de 21 à 30 jours (28 jours en moyenne). Certaines études peuvent être de plus longue durée (90 jours) : c’est le cas pour l’évaluation des vaccins qui prennent aussi en compte le phénomène de mémoire immunitaire avec les stratégies de rappels vaccinaux.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
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"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
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"R.W. Luebke",
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"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
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"J. Descotes",
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"P.C. Ryan",
"R. Stebbings",
"M. Walker",
"H.G. Haggerty",
"T. Hartung",
"E. Corsini",
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"P. Travers",
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"S. Ito",
"T. Aida",
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"T. Kimura",
"T. Furukawa",
"K. Mori",
"A. Sanbuissho",
"T. Kawada",
"L.D. Koller",
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"J. van Bilsen",
"H. Cnossen",
"G. Houben",
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"A. Wolterbeek",
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"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
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011DB975795A2F99BE9259140A301F1F20722D9A
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sec[3]/p[0]
|
Techniques d’évaluation du mécanisme de l’immunotoxicité
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[
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L’évaluation de l’immunotoxicité peut être réalisée in vivo (directement dans l’organisme vivant), in vitro (sur des cultures primaires ou des lignées cellulaires, la molécule testée étant ajoutée lors de la culture) ou ex vivo (les animaux sont traités puis les tissus ou les cellules sont prélevés pour être directement analysés ou cultivés in vitro ). Les tests sont observationnels ou fonctionnels.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
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https://doi.org/10.1051/jbio/2022020
|
N/A
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N/A
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Techniques d’évaluation du mécanisme de l’immunotoxicité
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La préoccupation du bien-être animal a eu comme conséquence la mise en place de la règle des 3R (réduire, remplacer, raffiner). De ce fait, les tests in vitro constituent une approche éthiquement mieux acceptée grâce à l’utilisation de cellules, de lignées cellulaires ou de composants cellulaires, de préférence issus de l’Homme. Cependant, il est nécessaire de bien caractériser les populations cellulaires car cette technique n’est pas toujours représentative des mécanismes en jeu dans un organisme entier . Par ailleurs, il n’est pas encore possible de reproduire correctement l’ensemble du processus de l’immunisation in vitro avec la totalité des partenaires cellulaires. C’est pourquoi les modèles animaux sont encore utiles et utilisés pour étudier ce processus de manière plus pertinente.
|
[
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"Lars Petter Jordheim",
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] |
https://doi.org/10.1051/jbio/2022020
|
N/A
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Techniques d’évaluation du mécanisme de l’immunotoxicité
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Selon la ligne directrice ICH S8, chaque test utilisé doit être validé par le laboratoire qui l’emploie pour répondre à des exigences qualité. Les critères de validation à démontrer sont au minimum la précision intra- et inter-essais, la détermination des limites de quantification et la stabilité des échantillons. Il est aussi recommandé de bien caractériser le contrôle positif, élément essentiel lors des analyses permettant de valider les résultats, et de travailler dans un environnement respectant les Bonnes Pratiques de Laboratoire.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
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"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
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| 0.999995
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011DB975795A2F99BE9259140A301F1F20722D9A
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sec[3]/sec[0]/p[0]
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Les tests observationnels en immunotoxicologie
| 2.941406
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biomedical
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[
0.99560546875,
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[
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|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
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"P. Italiani",
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"R.W. Luebke",
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"M. De La Morena",
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"T.O. Harville",
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"M. Ding",
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"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
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|
Les tests observationnels en immunotoxicologie
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biomedical
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[
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[
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L’anatomopathologie apprécie dans un premier temps sur le plan macroscopique la modification de la forme, la taille ou l’aspect des organes ou des tissus lymphoïdes comme le thymus, la rate et les ganglions lymphatiques drainant la zone d’administration du médicament . Lors des mesures, l’âge, le sexe, l’origine de l’élevage, l’état nutritionnel, les variations hormonales, le stress ou encore la présence d’infections ou de tumeurs sont notés. En effet, des variabilités inter-individuelles et intra-individuelles peuvent exister pour cette approche et doivent être prises en compte dans l’évaluation des risques.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
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"L. Canesi",
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"Y. Yang",
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"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
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"J.H. Dean",
"J.H. Dean",
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"R. Stebbings",
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"T. Hartung",
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"M. Walport",
"M.J. Shlomchik",
"P.W.F. Karmaus",
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"T.T. Kawabata",
"E.W. Evans",
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"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
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011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[3]/sec[0]/p[2]
|
Les tests observationnels en immunotoxicologie
| 3.925781
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biomedical
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Study
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[
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[
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L’anatomopathologie permet ensuite d’apprécier sur le plan microscopique et de manière semi-quantitative les modifications liées aux cellules des mêmes organes lymphoïdes . Des prélèvements complémentaires peuvent être réalisés en fonction de la voie d’administration du produit, comme par exemple les plaques de Peyer au niveau intestinal pour la voie orale, les tissus lymphoïdes associés aux bronches ( Bronchus-Associated Lymphoid Tissues ou BALT) et les tissus lymphoïdes associés à la cavité nasale ( Nasal-Associated Lymphoid Tissues ou NALT) pour la voie respiratoire.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
"H. Van Loveren",
"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
"J.H. Dean",
"J.R. Hincks",
"B. Remandet",
"J. Descotes",
"J. Descotes",
"J. Descotes",
"P. Wexler",
"R.Z. Dintzis",
"B. Vogelstein",
"H.M. Dintzis",
"M.A. Dobrovolskaia",
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"S.A. Elmore",
"EMA",
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"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
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| 0.999997
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011DB975795A2F99BE9259140A301F1F20722D9A_p17
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[3]/sec[0]/p[3]
|
Les tests observationnels en immunotoxicologie
| 4.101563
| 1.091593
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biomedical
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Study
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0.99853515625,
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[
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Les immunoglobulines sériques sont dosées de façon non spécifique (Ig totales) ou par isotype (IgG, IgM, IgA, IgE). Cette analyse permet de montrer l’aspect général de la réponse immunitaire humorale en cas d’anomalies des globulines et en absence d’étiologies hépatiques ou rénales. Le dosage des immunoglobulines sériques se fait principalement par technique ELISA ( Enzyme-Linked ImmunoSorbent Assay ) et plus rarement par immunofixation. Les limites de ce dosage s’expliquent par le fait que les résultats ne sont qu’un reflet de la réponse immunitaire humorale générale. Cette technique n’est pas informative dans le suivi d’un traitement en cours car elle ne prend en compte ni la stimulation antigénique, ni la spécificité antigénique c’est-à-dire la capacité d’un antigène à être reconnu par l’immunoglobuline.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
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"C. Boisseau",
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"J. Descotes",
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"B. Luebke",
"J. Botham",
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"E. Evans",
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"S.E. Loveless",
"H. Lu",
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"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
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"E. Corsini",
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"J.H. Dean",
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"D.M. Reed",
"G. Reichmann",
"P.C. Ryan",
"R. Stebbings",
"M. Walker",
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"T. Hartung",
"E. Corsini",
"C.J. Janeway",
"P. Travers",
"M. Walport",
"M.J. Shlomchik",
"P.W.F. Karmaus",
"A.L. Karmaus",
"R. Kaul",
"T.T. Kawabata",
"E.W. Evans",
"R. Kawai",
"S. Ito",
"T. Aida",
"H. Hattori",
"T. Kimura",
"T. Furukawa",
"K. Mori",
"A. Sanbuissho",
"T. Kawada",
"L.D. Koller",
"C.F. Kuper",
"J. van Bilsen",
"H. Cnossen",
"G. Houben",
"J. Garthoff",
"A. Wolterbeek",
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"J.G. Vos",
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"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999997
| 3.209159
| 3.999943
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011DB975795A2F99BE9259140A301F1F20722D9A
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|
Les tests observationnels en immunotoxicologie
| 4.117188
| 0.263906
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biomedical
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Study
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[
0.9990234375,
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[
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Les cytokines peuvent aussi être quantifiées afin de préciser le mécanisme d’immunotoxicité de la molécule étudiée. Cependant, plusieurs contraintes liées à leurs caractéristiques en limitent l’intérêt : elles ont une demi-vie brève, peuvent agir à longue distance et sont en faible concentration même après stimulation (de l’ordre du pg/mL) . En effet, contrairement aux hormones qui sont secrétées constitutivement et dont l’action est modulée en fonction de la quantité présente, les cytokines ne sont sécrétées qu’en réponse à un stimulus. Les analyses de cytokines peuvent être réalisées à partir de prélèvements de sang total ou de sérum ou à partir de cultures ex vivo ou in vitro , et peuvent concerner les molécules elles-mêmes par différentes techniques ELISA (singleplex, multiplex, ELISPOT), ou leurs ARN messagers par RT-PCR quantitative.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
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"K.L. White",
"Y. Yang",
"G.R. Burleson",
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"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
"H. Van Loveren",
"J.H. Dean",
"J.H. Dean",
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"T.R. Jerrells",
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"J.R. Hincks",
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"US EPA",
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"J.A. Moore",
"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999994
| 3.078673
| 3.98377
| 3.058609
| 3.93771
| 0.021032
| 0.971267
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| 3.280263
|
medical_knowledge
| 0.997702
|
questions
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| 0
| 0.999938
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| 0.999997
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| 0.999518
|
011DB975795A2F99BE9259140A301F1F20722D9A_p19
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[3]/sec[0]/p[5]
|
Les tests observationnels en immunotoxicologie
| 3.957031
| 1.921042
|
biomedical
|
Study
|
[
0.9970703125,
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[
0.80615234375,
0.190673828125,
0.0026416778564453125,
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Enfin, l’immunophénotypage permet l’identification et l’énumération des leucocytes par l’utilisation d’anticorps spécifiques de marqueurs de surface plus ou moins spécifiques d’un type cellulaire, et la cytométrie en flux ou l’immunohistochimie. Il permet d’observer la variation quantitative de cellules d’une population (pourcentage de cellules positives) ou le taux d’expression d’un marqueur (intensité du signal par cellule). Pour les études de toxicité à doses répétées, l’immunophénotypage permet de suivre les variations des populations cellulaires pendant les périodes avec et sans exposition à la molécule .
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
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"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
"H. Van Loveren",
"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
"J.H. Dean",
"J.R. Hincks",
"B. Remandet",
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"J. Descotes",
"J. Descotes",
"P. Wexler",
"R.Z. Dintzis",
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"C.F. Grant",
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"H. Prentice",
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"C. Charreyre",
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"C. Grimaldi",
"D. Finco",
"M.M. Fort",
"D. Gliddon",
"K. Harper",
"W.S. Helms",
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"R. O’Lone",
"S.T. Parish",
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"D.M. Reed",
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"P.C. Ryan",
"R. Stebbings",
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"T. Hartung",
"E. Corsini",
"C.J. Janeway",
"P. Travers",
"M. Walport",
"M.J. Shlomchik",
"P.W.F. Karmaus",
"A.L. Karmaus",
"R. Kaul",
"T.T. Kawabata",
"E.W. Evans",
"R. Kawai",
"S. Ito",
"T. Aida",
"H. Hattori",
"T. Kimura",
"T. Furukawa",
"K. Mori",
"A. Sanbuissho",
"T. Kawada",
"L.D. Koller",
"C.F. Kuper",
"J. van Bilsen",
"H. Cnossen",
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"J. Garthoff",
"A. Wolterbeek",
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"H. Lebrec",
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"C. Krejsa",
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"Y. Yang",
"L. Zhou",
"J. Arrington",
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"J. Shenton",
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"S. Lorenzo-Herrero",
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"S. González",
"A. López-Soto",
"M.I. Luster",
"S. Mahalingam",
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"V.S. Kalyanaraman",
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"K. Muthumani",
"P.L. Martin",
"S. Meunier",
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"M. Hamze",
"A. Azam",
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"C. Menier",
"B. Maillère",
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"OECD",
"OECD",
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"A. Dasgupta",
"J.S. Orange",
"M. Ballow",
"E.R. Stiehm",
"Z.K. Ballas",
"J. Chinen",
"M. De La Morena",
"D. Kumararatne",
"T.O. Harville",
"P. Hesterberg",
"M. Koleilat",
"S. McGhee",
"E.E. Perez",
"J. Raasch",
"R. Scherzer",
"H. Schroeder",
"C. Seroogy",
"A. Huissoon",
"R.U. Sorensen",
"R. Katial",
"V.L. Peachee",
"M.J. Smith",
"M.J. Beck",
"D.G. Stump",
"K.L. White",
"L. Peyton Myers",
"L.M. Plitnick",
"D.J. Herzyk",
"L.M. Plunkett",
"A.M. Kaplan",
"R.A. Becker",
"T.M. Potter",
"B.W. Neun",
"M.A. Dobrovolskaia",
"T. Rabadi",
"M.F. Brady",
"L. Richards",
"B. Erko",
"K. Ponpetch",
"S.J. Ryan",
"S. Liang",
"A.N. Rumianek",
"D.R. Greaves",
"ScienceDirect",
"R. Sharon",
"P.R. McMaster",
"A.M. Kask",
"J.D. Owens",
"W.E. Paul",
"L. Taylor",
"C. Recio",
"D.R. Greaves",
"A.J. Iqbal",
"The European Commission",
"Thériaque",
"Thériaque",
"Thériaque",
"US EPA",
"US EPA",
"US EPA",
"J.G. Vos",
"J.A. Moore",
"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999997
| 3.029265
| 3.961603
| 3.072217
| 4.021204
| -0.015684
| 0.958792
| -0.000684
| 3.160317
| -5.866442
| 6.641238
| 0.378847
| 0.096298
| 0.028947
| 3.800902
|
medical_knowledge
| 0.998409
|
questions
| 0.999391
| 0
| 0.999914
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| 0.999806
|
011DB975795A2F99BE9259140A301F1F20722D9A_p20
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[3]/sec[1]/p[0]
|
Les tests fonctionnels en immunotoxicologie
| 2.033203
| 0.892151
|
biomedical
|
Other
|
[
0.9853515625,
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[
0.038787841796875,
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Les tests fonctionnels renseignent sur la fonction immunitaire et aident à caractériser les mécanismes d’immunotoxicité. Ils peuvent être réalisés in vitro ou in vivo .
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
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"J.-J. Legrand",
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"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
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"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
"H. Van Loveren",
"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
"J.H. Dean",
"J.R. Hincks",
"B. Remandet",
"J. Descotes",
"J. Descotes",
"J. Descotes",
"P. Wexler",
"R.Z. Dintzis",
"B. Vogelstein",
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"M. Mitjans",
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"D. Germolec",
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"A. Rooney",
"K. Shipkowski",
"R. Vandebriel",
"H. van Loveren",
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"K.A. Shipkowski",
"R.P. Frawley",
"E. Evans",
"H. Geyer",
"M. Wuhrer",
"A. Resemann",
"R. Geyer",
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"E.A. Lefevre",
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"H. Prentice",
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"A.J. Pollard",
"C. Charreyre",
"B. Charleston",
"C. Grimaldi",
"D. Finco",
"M.M. Fort",
"D. Gliddon",
"K. Harper",
"W.S. Helms",
"J.A. Mitchell",
"R. O’Lone",
"S.T. Parish",
"M.-S. Piche",
"D.M. Reed",
"G. Reichmann",
"P.C. Ryan",
"R. Stebbings",
"M. Walker",
"H.G. Haggerty",
"T. Hartung",
"E. Corsini",
"C.J. Janeway",
"P. Travers",
"M. Walport",
"M.J. Shlomchik",
"P.W.F. Karmaus",
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"R. Kaul",
"T.T. Kawabata",
"E.W. Evans",
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"T. Aida",
"H. Hattori",
"T. Kimura",
"T. Furukawa",
"K. Mori",
"A. Sanbuissho",
"T. Kawada",
"L.D. Koller",
"C.F. Kuper",
"J. van Bilsen",
"H. Cnossen",
"G. Houben",
"J. Garthoff",
"A. Wolterbeek",
"G.S. Ladics",
"H. Lebrec",
"L. Cowan",
"M. Lagrou",
"C. Krejsa",
"M.B. Neradilek",
"N.L. Polissar",
"L. Black",
"J. Bussière",
"H. Lebrec",
"B. Molinier",
"D. Boverhof",
"M. Collinge",
"W. Freebern",
"K. Henson",
"D.T. Mytych",
"H.D. Ochs",
"R. Wange",
"Y. Yang",
"L. Zhou",
"J. Arrington",
"M.S. Christin-Piché",
"J. Shenton",
"D.Y. Logel",
"P.R. Jaschke",
"S. Lorenzo-Herrero",
"C. Sordo-Bahamonde",
"S. González",
"A. López-Soto",
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"S. Mahalingam",
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"J.S. Orange",
"M. Ballow",
"E.R. Stiehm",
"Z.K. Ballas",
"J. Chinen",
"M. De La Morena",
"D. Kumararatne",
"T.O. Harville",
"P. Hesterberg",
"M. Koleilat",
"S. McGhee",
"E.E. Perez",
"J. Raasch",
"R. Scherzer",
"H. Schroeder",
"C. Seroogy",
"A. Huissoon",
"R.U. Sorensen",
"R. Katial",
"V.L. Peachee",
"M.J. Smith",
"M.J. Beck",
"D.G. Stump",
"K.L. White",
"L. Peyton Myers",
"L.M. Plitnick",
"D.J. Herzyk",
"L.M. Plunkett",
"A.M. Kaplan",
"R.A. Becker",
"T.M. Potter",
"B.W. Neun",
"M.A. Dobrovolskaia",
"T. Rabadi",
"M.F. Brady",
"L. Richards",
"B. Erko",
"K. Ponpetch",
"S.J. Ryan",
"S. Liang",
"A.N. Rumianek",
"D.R. Greaves",
"ScienceDirect",
"R. Sharon",
"P.R. McMaster",
"A.M. Kask",
"J.D. Owens",
"W.E. Paul",
"L. Taylor",
"C. Recio",
"D.R. Greaves",
"A.J. Iqbal",
"The European Commission",
"Thériaque",
"Thériaque",
"Thériaque",
"US EPA",
"US EPA",
"US EPA",
"J.G. Vos",
"J.A. Moore",
"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999997
| 2.193923
| 4.160722
| 2.133715
| 3.238583
| -0.010507
| 0.987674
| -0.000868
| 2.648847
| -6.088927
| 6.441681
| 0.011457
| 0.036954
| 0.028041
| 4.049484
|
medical_knowledge
| 0.999428
|
questions
| 0.998798
| 0
| 0.999763
| 1
| 0.999983
| 1
| 0.99826
|
011DB975795A2F99BE9259140A301F1F20722D9A_p21
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[3]/sec[1]/sec[0]/p[0]
|
Tests in vitro et ex vivo
| 3.525391
| 2.093406
|
biomedical
|
Study
|
[
0.9970703125,
0.00030040740966796875,
0.002628326416015625
] |
[
0.66845703125,
0.3291015625,
0.0018415451049804688,
0.0004558563232421875
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Les tests fonctionnels in vitro utilisant des cultures cellulaires ont été développés après l’émergence de la notion du bien-être animal et l’application de la règle des 3R. Ils englobent le test de prolifération lymphocytaire (lymphocytes B et T), la mesure de l’activité des cellules NK, le test de relargage des cytokines et la mesure de l’activité des macrophages et des polynucléaires.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
"H. Van Loveren",
"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
"J.H. Dean",
"J.R. Hincks",
"B. Remandet",
"J. Descotes",
"J. Descotes",
"J. Descotes",
"P. Wexler",
"R.Z. Dintzis",
"B. Vogelstein",
"H.M. Dintzis",
"M.A. Dobrovolskaia",
"S.E. McNeil",
"S.A. Elmore",
"EMA",
"EMA",
"S.T. Espenschied",
"R.M. Tighe",
"K.M. Gowdy",
"J.T. Farmer",
"R.R. Dietert",
"A.S. Faqi",
"V. Galbiati",
"M. Mitjans",
"E. Corsini",
"D. Germolec",
"R. Luebke",
"A. Rooney",
"K. Shipkowski",
"R. Vandebriel",
"H. van Loveren",
"D.R. Germolec",
"K.A. Shipkowski",
"R.P. Frawley",
"E. Evans",
"H. Geyer",
"M. Wuhrer",
"A. Resemann",
"R. Geyer",
"C.F. Grant",
"E.A. Lefevre",
"B.V. Carr",
"H. Prentice",
"S. Gubbins",
"A.J. Pollard",
"C. Charreyre",
"B. Charleston",
"C. Grimaldi",
"D. Finco",
"M.M. Fort",
"D. Gliddon",
"K. Harper",
"W.S. Helms",
"J.A. Mitchell",
"R. O’Lone",
"S.T. Parish",
"M.-S. Piche",
"D.M. Reed",
"G. Reichmann",
"P.C. Ryan",
"R. Stebbings",
"M. Walker",
"H.G. Haggerty",
"T. Hartung",
"E. Corsini",
"C.J. Janeway",
"P. Travers",
"M. Walport",
"M.J. Shlomchik",
"P.W.F. Karmaus",
"A.L. Karmaus",
"R. Kaul",
"T.T. Kawabata",
"E.W. Evans",
"R. Kawai",
"S. Ito",
"T. Aida",
"H. Hattori",
"T. Kimura",
"T. Furukawa",
"K. Mori",
"A. Sanbuissho",
"T. Kawada",
"L.D. Koller",
"C.F. Kuper",
"J. van Bilsen",
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"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
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| 0.999996
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medical_knowledge
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011DB975795A2F99BE9259140A301F1F20722D9A_p22
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011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[3]/sec[1]/sec[0]/p[1]
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Tests in vitro et ex vivo
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biomedical
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Le test de prolifération lymphocytaire repose sur la capacité des lymphocytes (T ou B) à répondre à une stimulation antigénique, ce qui constitue un paramètre de l’immunité cellulaire. Cette réponse est mesurée par leur capacité de prolifération en culture in vitro . La stimulation antigénique est médiée par l’utilisation de mitogènes comme le lipopolysaccharide d’ Escherichia coli pour les lymphocytes B et les anticorps anti-CD3 et anti-CD28 pour les lymphocytes T. La prolifération est estimée par la mesure de l’incorporation de la thymidine tritiée dans l’ADN, ou par la quantification de la bromodésoxyuridine ou de l’antigène PCNA ( Proliferating Cell Nuclear Antigen ) par cytométrie en flux.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
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"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
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011DB975795A2F99BE9259140A301F1F20722D9A
|
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biomedical
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Study
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[
0.9931640625,
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L’activité des cellules NK est mesurée si l’immunophénotypage montre une anomalie numérique de ces cellules ou si une augmentation du taux d’incidence d’infections virales ou de tumeurs est observée chez les animaux lors des études précliniques. Il s’agît d’un test de relargage du chrome 51 ( 51 Cr) par les cellules cibles, en l’occurrence des cellules tumorales ne présentant pas à leur surface des molécules du complexe majeur d’histocompatibilité (CMH) de classe I préalablement marquées par le 51 Cr et qui sont lysées par les cellules NK secrétant les perforines et les granzymes lors d’une coculture. La quantification de la radioactivité libérée par les cellules informe sur l’efficacité de la lyse des cellules cibles par les cellules NK. Des méthodes non radioactives utilisant la calcéine acétoxyméthylée ou l’ester succinimidylique de carboxyfluorescéine sont de plus en plus utilisées. L’activité cytolytique des lymphocytes TCD8+ est aussi mesurée par le test du relargage du 51 Cr mais nécessite une activation préalable par les lymphocytes TCD4+ helper afin d’exprimer à leur surface des récepteurs spécifiques de l’antigène.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
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"S. Perrot",
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"G.R. Burleson",
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"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
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medical_knowledge
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011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[3]/sec[1]/sec[0]/p[3]
|
Tests in vitro et ex vivo
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| 1.306428
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biomedical
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Study
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[
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0.00016021728515625
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Les macrophages et les polynucléaires jouent un rôle dans l’inflammation via leur capacité de migration par chimiotactisme, de phagocytose, de présentation d’antigènes ou encore de synthèse de cytokines pro-inflammatoires . Le chimiotactisme est évalué par le test de migration cellulaire dans une chambre de Boyden avec les cellules d’un côté de la membrane et les molécules chimio-attractantes de l’autre . La capacité migratoire est quantifiée par microscopie et comptage cellulaire, par cytométrie en flux ou par la mesure de l’impédance électrique des cellules . Le test de phagocytose utilise des agents immunogènes (billes de latex, particules de zymosan, bactéries, champignons) couplés avec un fluorochrome . Ces agents sont incubés pendant quelques heures avec les macrophages ou les polynucléaires et phagocytés par ces derniers. Après incubation, la capacité à phagocyter des cellules est déterminée par microscopie confocale (macrophages contenant des particules fluorescentes) ou par cytométrie en flux (mesure de l’intensité de fluorescence) .
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
"H. Van Loveren",
"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
"J.H. Dean",
"J.R. Hincks",
"B. Remandet",
"J. Descotes",
"J. Descotes",
"J. Descotes",
"P. Wexler",
"R.Z. Dintzis",
"B. Vogelstein",
"H.M. Dintzis",
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"EMA",
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"M. Mitjans",
"E. Corsini",
"D. Germolec",
"R. Luebke",
"A. Rooney",
"K. Shipkowski",
"R. Vandebriel",
"H. van Loveren",
"D.R. Germolec",
"K.A. Shipkowski",
"R.P. Frawley",
"E. Evans",
"H. Geyer",
"M. Wuhrer",
"A. Resemann",
"R. Geyer",
"C.F. Grant",
"E.A. Lefevre",
"B.V. Carr",
"H. Prentice",
"S. Gubbins",
"A.J. Pollard",
"C. Charreyre",
"B. Charleston",
"C. Grimaldi",
"D. Finco",
"M.M. Fort",
"D. Gliddon",
"K. Harper",
"W.S. Helms",
"J.A. Mitchell",
"R. O’Lone",
"S.T. Parish",
"M.-S. Piche",
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"G. Reichmann",
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"R. Stebbings",
"M. Walker",
"H.G. Haggerty",
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"E. Corsini",
"C.J. Janeway",
"P. Travers",
"M. Walport",
"M.J. Shlomchik",
"P.W.F. Karmaus",
"A.L. Karmaus",
"R. Kaul",
"T.T. Kawabata",
"E.W. Evans",
"R. Kawai",
"S. Ito",
"T. Aida",
"H. Hattori",
"T. Kimura",
"T. Furukawa",
"K. Mori",
"A. Sanbuissho",
"T. Kawada",
"L.D. Koller",
"C.F. Kuper",
"J. van Bilsen",
"H. Cnossen",
"G. Houben",
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"A. Wolterbeek",
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"H. Lebrec",
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"M.S. Christin-Piché",
"J. Shenton",
"D.Y. Logel",
"P.R. Jaschke",
"S. Lorenzo-Herrero",
"C. Sordo-Bahamonde",
"S. González",
"A. López-Soto",
"M.I. Luster",
"S. Mahalingam",
"J. Peter",
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"M. Ho",
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"OECD",
"OECD",
"OECD",
"M. Oellerich",
"G. Brandhorst",
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"A. Dasgupta",
"J.S. Orange",
"M. Ballow",
"E.R. Stiehm",
"Z.K. Ballas",
"J. Chinen",
"M. De La Morena",
"D. Kumararatne",
"T.O. Harville",
"P. Hesterberg",
"M. Koleilat",
"S. McGhee",
"E.E. Perez",
"J. Raasch",
"R. Scherzer",
"H. Schroeder",
"C. Seroogy",
"A. Huissoon",
"R.U. Sorensen",
"R. Katial",
"V.L. Peachee",
"M.J. Smith",
"M.J. Beck",
"D.G. Stump",
"K.L. White",
"L. Peyton Myers",
"L.M. Plitnick",
"D.J. Herzyk",
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"A.M. Kaplan",
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"B.W. Neun",
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"T. Rabadi",
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"S. Liang",
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"D.R. Greaves",
"ScienceDirect",
"R. Sharon",
"P.R. McMaster",
"A.M. Kask",
"J.D. Owens",
"W.E. Paul",
"L. Taylor",
"C. Recio",
"D.R. Greaves",
"A.J. Iqbal",
"The European Commission",
"Thériaque",
"Thériaque",
"Thériaque",
"US EPA",
"US EPA",
"US EPA",
"J.G. Vos",
"J.A. Moore",
"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999994
| 3.044166
| 3.996732
| 3.012064
| 4.019022
| -0.006679
| 0.984373
| -0.001337
| 5.303553
| -7.094674
| 6.059604
| 0.025934
| -0.016303
| 0.147988
| 3.33689
|
medical_knowledge
| 0.999269
|
questions
| 0.999527
| 0
| 0.999933
| 1
| 0.99999
| 1
| 0.999438
|
011DB975795A2F99BE9259140A301F1F20722D9A_p25
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[3]/sec[1]/sec[0]/p[4]
|
Tests in vitro et ex vivo
| 3.851563
| 1.415311
|
biomedical
|
Study
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[
0.99755859375,
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[
0.740234375,
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Enfin, le test de relargage des cytokines, bien qu’il ne soit pas présent dans l’ICH S8, est utile dans le développement des produits issus des biotechnologies. Il permet de mettre en évidence le syndrome de relargage des cytokines ou tempête cytokinique (réponse anormale par une production excessive de cytokines). Ce phénomène est observé par exemple en réponse à l’administration de certains anticorps monoclonaux thérapeutiques ou de cellules CAR-T , ou encore à la suite de toute stimulation non contrôlée du système immunitaire. Le principe consiste à mettre en culture les cellules du sang total ou les cellules mononuclées du sang périphérique en présence de la molécule à tester, et de doser les cytokines sécrétées dans le surnageant de culture par une technique ELISA.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
"H. Van Loveren",
"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
"J.H. Dean",
"J.R. Hincks",
"B. Remandet",
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"J. Descotes",
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"R. Stebbings",
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"H.G. Haggerty",
"T. Hartung",
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"E.W. Evans",
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"S. Ito",
"T. Aida",
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"T. Kimura",
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"J. Chinen",
"M. De La Morena",
"D. Kumararatne",
"T.O. Harville",
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"S. McGhee",
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"J. Raasch",
"R. Scherzer",
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"R. Katial",
"V.L. Peachee",
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"D.J. Herzyk",
"L.M. Plunkett",
"A.M. Kaplan",
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"T.M. Potter",
"B.W. Neun",
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"L. Richards",
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"S. Liang",
"A.N. Rumianek",
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"ScienceDirect",
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"A.M. Kask",
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"Thériaque",
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"J.G. Vos",
"J.A. Moore",
"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999996
| 2.988369
| 3.95009
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| 4.010899
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| 0.964526
| -0.001489
| 3.971735
| -5.405223
| 5.945347
| 0.037219
| 1.013886
| 0.027618
| 2.791461
|
medical_knowledge
| 0.998267
|
questions
| 0.999608
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| 0.999936
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| 0.999983
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| 0.999852
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011DB975795A2F99BE9259140A301F1F20722D9A_p26
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011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[3]/sec[1]/sec[1]/p[0]
|
Tests in vivo
| 2.861328
| 1.25863
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biomedical
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Other
|
[
0.9931640625,
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[
0.1634521484375,
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Les tests fonctionnels in vivo permettent de suivre les mécanismes en aval d’un processus d’immunisation qui ne peut pas se faire in vitro . Ces tests fonctionnels in vivo comprennent l’évaluation de la réponse humorale, de l’hypersensibilité retardée et de la résistance de l’hôte.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
"H. Van Loveren",
"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
"J.H. Dean",
"J.R. Hincks",
"B. Remandet",
"J. Descotes",
"J. Descotes",
"J. Descotes",
"P. Wexler",
"R.Z. Dintzis",
"B. Vogelstein",
"H.M. Dintzis",
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"S.A. Elmore",
"EMA",
"EMA",
"S.T. Espenschied",
"R.M. Tighe",
"K.M. Gowdy",
"J.T. Farmer",
"R.R. Dietert",
"A.S. Faqi",
"V. Galbiati",
"M. Mitjans",
"E. Corsini",
"D. Germolec",
"R. Luebke",
"A. Rooney",
"K. Shipkowski",
"R. Vandebriel",
"H. van Loveren",
"D.R. Germolec",
"K.A. Shipkowski",
"R.P. Frawley",
"E. Evans",
"H. Geyer",
"M. Wuhrer",
"A. Resemann",
"R. Geyer",
"C.F. Grant",
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"H. Prentice",
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"H. Hattori",
"T. Kimura",
"T. Furukawa",
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"A. Sanbuissho",
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"L.D. Koller",
"C.F. Kuper",
"J. van Bilsen",
"H. Cnossen",
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"A. López-Soto",
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"Z.K. Ballas",
"J. Chinen",
"M. De La Morena",
"D. Kumararatne",
"T.O. Harville",
"P. Hesterberg",
"M. Koleilat",
"S. McGhee",
"E.E. Perez",
"J. Raasch",
"R. Scherzer",
"H. Schroeder",
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"A. Huissoon",
"R.U. Sorensen",
"R. Katial",
"V.L. Peachee",
"M.J. Smith",
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"D.G. Stump",
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"L. Peyton Myers",
"L.M. Plitnick",
"D.J. Herzyk",
"L.M. Plunkett",
"A.M. Kaplan",
"R.A. Becker",
"T.M. Potter",
"B.W. Neun",
"M.A. Dobrovolskaia",
"T. Rabadi",
"M.F. Brady",
"L. Richards",
"B. Erko",
"K. Ponpetch",
"S.J. Ryan",
"S. Liang",
"A.N. Rumianek",
"D.R. Greaves",
"ScienceDirect",
"R. Sharon",
"P.R. McMaster",
"A.M. Kask",
"J.D. Owens",
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"D.R. Greaves",
"A.J. Iqbal",
"The European Commission",
"Thériaque",
"Thériaque",
"Thériaque",
"US EPA",
"US EPA",
"US EPA",
"J.G. Vos",
"J.A. Moore",
"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999996
| 2.684865
| 4.061153
| 2.894191
| 3.865222
| -0.009512
| 0.967744
| -0.003114
| 4.859884
| -5.746692
| 6.729764
| -0.009049
| 0.017097
| 0.225738
| 3.777354
|
medical_knowledge
| 0.998223
|
questions
| 0.999465
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| 0.999938
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| 0.999995
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|
011DB975795A2F99BE9259140A301F1F20722D9A_p27
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[3]/sec[1]/sec[1]/p[1]
|
Tests in vivo
| 2.988281
| 2.736132
|
biomedical
|
Other
|
[
0.99267578125,
0.0005574226379394531,
0.006999969482421875
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[
0.16943359375,
0.82763671875,
0.0021762847900390625,
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] |
L’évaluation de la réponse humorale est essentielle en immunotoxicologie car elle permet d’explorer l’ensemble des fonctions immunitaires liées à la réponse adaptative humorale . Elle consiste à immuniser l’animal par un antigène thymo-dépendant ou thymo-indépendant.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
"H. Van Loveren",
"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
"J.H. Dean",
"J.R. Hincks",
"B. Remandet",
"J. Descotes",
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"K.A. Shipkowski",
"R.P. Frawley",
"E. Evans",
"H. Geyer",
"M. Wuhrer",
"A. Resemann",
"R. Geyer",
"C.F. Grant",
"E.A. Lefevre",
"B.V. Carr",
"H. Prentice",
"S. Gubbins",
"A.J. Pollard",
"C. Charreyre",
"B. Charleston",
"C. Grimaldi",
"D. Finco",
"M.M. Fort",
"D. Gliddon",
"K. Harper",
"W.S. Helms",
"J.A. Mitchell",
"R. O’Lone",
"S.T. Parish",
"M.-S. Piche",
"D.M. Reed",
"G. Reichmann",
"P.C. Ryan",
"R. Stebbings",
"M. Walker",
"H.G. Haggerty",
"T. Hartung",
"E. Corsini",
"C.J. Janeway",
"P. Travers",
"M. Walport",
"M.J. Shlomchik",
"P.W.F. Karmaus",
"A.L. Karmaus",
"R. Kaul",
"T.T. Kawabata",
"E.W. Evans",
"R. Kawai",
"S. Ito",
"T. Aida",
"H. Hattori",
"T. Kimura",
"T. Furukawa",
"K. Mori",
"A. Sanbuissho",
"T. Kawada",
"L.D. Koller",
"C.F. Kuper",
"J. van Bilsen",
"H. Cnossen",
"G. Houben",
"J. Garthoff",
"A. Wolterbeek",
"G.S. Ladics",
"H. Lebrec",
"L. Cowan",
"M. Lagrou",
"C. Krejsa",
"M.B. Neradilek",
"N.L. Polissar",
"L. Black",
"J. Bussière",
"H. Lebrec",
"B. Molinier",
"D. Boverhof",
"M. Collinge",
"W. Freebern",
"K. Henson",
"D.T. Mytych",
"H.D. Ochs",
"R. Wange",
"Y. Yang",
"L. Zhou",
"J. Arrington",
"M.S. Christin-Piché",
"J. Shenton",
"D.Y. Logel",
"P.R. Jaschke",
"S. Lorenzo-Herrero",
"C. Sordo-Bahamonde",
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"M. Oellerich",
"G. Brandhorst",
"M. Shipkova",
"E. Wieland",
"A. Dasgupta",
"J.S. Orange",
"M. Ballow",
"E.R. Stiehm",
"Z.K. Ballas",
"J. Chinen",
"M. De La Morena",
"D. Kumararatne",
"T.O. Harville",
"P. Hesterberg",
"M. Koleilat",
"S. McGhee",
"E.E. Perez",
"J. Raasch",
"R. Scherzer",
"H. Schroeder",
"C. Seroogy",
"A. Huissoon",
"R.U. Sorensen",
"R. Katial",
"V.L. Peachee",
"M.J. Smith",
"M.J. Beck",
"D.G. Stump",
"K.L. White",
"L. Peyton Myers",
"L.M. Plitnick",
"D.J. Herzyk",
"L.M. Plunkett",
"A.M. Kaplan",
"R.A. Becker",
"T.M. Potter",
"B.W. Neun",
"M.A. Dobrovolskaia",
"T. Rabadi",
"M.F. Brady",
"L. Richards",
"B. Erko",
"K. Ponpetch",
"S.J. Ryan",
"S. Liang",
"A.N. Rumianek",
"D.R. Greaves",
"ScienceDirect",
"R. Sharon",
"P.R. McMaster",
"A.M. Kask",
"J.D. Owens",
"W.E. Paul",
"L. Taylor",
"C. Recio",
"D.R. Greaves",
"A.J. Iqbal",
"The European Commission",
"Thériaque",
"Thériaque",
"Thériaque",
"US EPA",
"US EPA",
"US EPA",
"J.G. Vos",
"J.A. Moore",
"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999998
| 2.798033
| 4.037928
| 2.919667
| 3.975271
| -0.026198
| 0.999099
| -0.001526
| 5.177557
| -6.149052
| 6.59709
| -0.095193
| -0.023746
| -0.033864
| 3.668528
|
medical_knowledge
| 0.999391
|
questions
| 0.999747
| 0
| 0.999955
| 1
| 0.999993
| 1
| 0.999446
|
011DB975795A2F99BE9259140A301F1F20722D9A_p28
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[3]/sec[1]/sec[1]/p[2]
|
Tests in vivo
| 3.625
| 1.378332
|
biomedical
|
Other
|
[
0.9951171875,
0.0006055831909179688,
0.004261016845703125
] |
[
0.316650390625,
0.6806640625,
0.0020160675048828125,
0.0006647109985351562
] |
L’évaluation de la réponse thymo-dépendante ( T-cell Dependent Antibody Response ou TDAR) s’effectue en deux temps, avec d’abord l’immunisation des animaux par un antigène thymo-dépendant, puis la mesure des anticorps spécifiques dirigés contre cet antigène. Ce test est recommandé en première intention car il permet d’explorer les différentes composantes de l’immunité humorale comme les cellules présentatrices d’antigène, les lymphocytes T et B mais aussi la synthèse des IgM et des IgG spécifiques contre l’antigène. Ce test sera plus largement développé dans la partie suivante.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
"H.V. Loveren",
"W.H. De Jong",
"H. Van Loveren",
"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
"J.H. Dean",
"J.R. Hincks",
"B. Remandet",
"J. Descotes",
"J. Descotes",
"J. Descotes",
"P. Wexler",
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"EMA",
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"R.M. Tighe",
"K.M. Gowdy",
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"R. Luebke",
"A. Rooney",
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"R. Vandebriel",
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"D.R. Germolec",
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"R.P. Frawley",
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"M. Wuhrer",
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"R. Geyer",
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"E.A. Lefevre",
"B.V. Carr",
"H. Prentice",
"S. Gubbins",
"A.J. Pollard",
"C. Charreyre",
"B. Charleston",
"C. Grimaldi",
"D. Finco",
"M.M. Fort",
"D. Gliddon",
"K. Harper",
"W.S. Helms",
"J.A. Mitchell",
"R. O’Lone",
"S.T. Parish",
"M.-S. Piche",
"D.M. Reed",
"G. Reichmann",
"P.C. Ryan",
"R. Stebbings",
"M. Walker",
"H.G. Haggerty",
"T. Hartung",
"E. Corsini",
"C.J. Janeway",
"P. Travers",
"M. Walport",
"M.J. Shlomchik",
"P.W.F. Karmaus",
"A.L. Karmaus",
"R. Kaul",
"T.T. Kawabata",
"E.W. Evans",
"R. Kawai",
"S. Ito",
"T. Aida",
"H. Hattori",
"T. Kimura",
"T. Furukawa",
"K. Mori",
"A. Sanbuissho",
"T. Kawada",
"L.D. Koller",
"C.F. Kuper",
"J. van Bilsen",
"H. Cnossen",
"G. Houben",
"J. Garthoff",
"A. Wolterbeek",
"G.S. Ladics",
"H. Lebrec",
"L. Cowan",
"M. Lagrou",
"C. Krejsa",
"M.B. Neradilek",
"N.L. Polissar",
"L. Black",
"J. Bussière",
"H. Lebrec",
"B. Molinier",
"D. Boverhof",
"M. Collinge",
"W. Freebern",
"K. Henson",
"D.T. Mytych",
"H.D. Ochs",
"R. Wange",
"Y. Yang",
"L. Zhou",
"J. Arrington",
"M.S. Christin-Piché",
"J. Shenton",
"D.Y. Logel",
"P.R. Jaschke",
"S. Lorenzo-Herrero",
"C. Sordo-Bahamonde",
"S. González",
"A. López-Soto",
"M.I. Luster",
"S. Mahalingam",
"J. Peter",
"Z. Xu",
"D. Bordoloi",
"M. Ho",
"V.S. Kalyanaraman",
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"G. Brandhorst",
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"E. Wieland",
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"J.S. Orange",
"M. Ballow",
"E.R. Stiehm",
"Z.K. Ballas",
"J. Chinen",
"M. De La Morena",
"D. Kumararatne",
"T.O. Harville",
"P. Hesterberg",
"M. Koleilat",
"S. McGhee",
"E.E. Perez",
"J. Raasch",
"R. Scherzer",
"H. Schroeder",
"C. Seroogy",
"A. Huissoon",
"R.U. Sorensen",
"R. Katial",
"V.L. Peachee",
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"D.J. Herzyk",
"L.M. Plunkett",
"A.M. Kaplan",
"R.A. Becker",
"T.M. Potter",
"B.W. Neun",
"M.A. Dobrovolskaia",
"T. Rabadi",
"M.F. Brady",
"L. Richards",
"B. Erko",
"K. Ponpetch",
"S.J. Ryan",
"S. Liang",
"A.N. Rumianek",
"D.R. Greaves",
"ScienceDirect",
"R. Sharon",
"P.R. McMaster",
"A.M. Kask",
"J.D. Owens",
"W.E. Paul",
"L. Taylor",
"C. Recio",
"D.R. Greaves",
"A.J. Iqbal",
"The European Commission",
"Thériaque",
"Thériaque",
"Thériaque",
"US EPA",
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"US EPA",
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"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999996
| 3.094359
| 4.018559
| 3.034317
| 3.955161
| -0.003974
| 0.971983
| -0.003657
| 4.206373
| -5.505435
| 6.37332
| 0.054546
| 1.006887
| 0.161481
| 3.255138
|
medical_knowledge
| 0.994565
|
questions
| 0.999431
| 0
| 0.999699
| 1
| 0.999956
| 1
| 0.999354
|
011DB975795A2F99BE9259140A301F1F20722D9A_p29
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[3]/sec[1]/sec[1]/p[3]
|
Tests in vivo
| 4.054688
| 1.218908
|
biomedical
|
Study
|
[
0.998046875,
0.0003113746643066406,
0.00167083740234375
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[
0.9521484375,
0.045867919921875,
0.0016508102416992188,
0.00023686885833740234
] |
L’évaluation de la réponse thymo-indépendante ( T-cell Independent Antibody Response ou TIAR) n’est utilisée que dans des cas très précis. En effet elle permet de déterminer l’état fonctionnel des lymphocytes B et de préciser les mécanismes toxiques de la molécule testée sur cette population cellulaire . Comme pour le test TDAR, l’évaluation de la réponse thymo-indépendante repose sur le principe d’immunisation puis de mesure des anticorps spécifiques . Les antigènes thymo-indépendants utilisés sont le 2,4 dinitrophényl-Ficoll (DNP-Ficoll), le lipopolysaccharide conjugué à l’haptène 2,4,6-trinitrophényl (TNP-LPS), l’acide polyinosinique-polycytidylique (CpG) et la flagelline .
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
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"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
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L’hypersensibilité retardée à un antigène permet d’évaluer l’immunité cellulaire chez les souris, les rats et les singes en utilisant le test de stimulation locale du ganglion lymphatique ( Local Lymph Node Assay ou LLNA) ou de prolifération locale du ganglion lymphatique ( Local Lymph Node Proliferation ou LLNP) . Le principe de ces tests repose sur l’immunisation quotidienne des animaux avec un antigène (KLH ou keyhole limpet hemocyanin , ovalbumine, anatoxine tétanique ou des nanoparticules) pendant trois jours. L’antigène est appliqué sur la peau de l’oreille de l’animal dans le test LLNA et injecté dans le test LLNP. Après une phase de repos de 3 jours, la thymidine tritiée est injectée chez l’animal qui est sacrifié 6 heures plus tard et les ganglions lymphatiques sont prélevés pour analyse. Les paramètres qui sont analysés sur l’animal entier ou sur des prélèvements sont la taille de l’inflammation au niveau des oreilles (rougeur, œdème ; paramètre macroscopique), l’infiltration des macrophages et des lymphocytes T au niveau des oreilles et des ganglions drainants (paramètre microscopique) et la mesure de la lymphoprolifération par la thymidine tritiée.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
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"B.W. Neun",
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"B. Erko",
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"A.N. Rumianek",
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"Thériaque",
"Thériaque",
"Thériaque",
"US EPA",
"US EPA",
"US EPA",
"J.G. Vos",
"J.A. Moore",
"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
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biomedical
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Enfin, l’étude de résistance de l’hôte face à l’inoculation d’un agent infectieux (bactérie, champignon, virus ou parasite), ou de cellules cancéreuses en présence de la molécule à tester, est une autre approche pour évaluer la fonction immunitaire dans sa globalité . L’étude de résistance de l’hôte s’intéresse à la capacité d’un organisme à éliminer un agent infectieux (clairance). Ce test dure en général 28 jours et utilise deux espèces de rongeurs (rats, souris), dont l’une est le contrôle négatif. Le virus de la grippe est le modèle infectieux le plus utilisé mais d’autres agents pathogènes peuvent l’être également pour cibler une population cellulaire ou un organe spécifique. Ainsi, Streptococcus pneumoniae est employé pour l’étude des neutrophiles, des macrophages, des anti-inflammatoires ou de molécules ciblant TNFα, Listeria monocytogenes pour les cellules de Küpfler et les macrophages alvéolaires, Candida albicans comme modèle fongique, le cytomégalovirus murin pour la latence et la réactivation virale, et Plasmodium yoelii et Trichinella spiralis pour les modèles parasitaires. Après inoculation, la charge biologique, c’est-à-dire la quantité de micro-organismes présents dans un tissu comme le sang, la rate, le poumon ou le foie, est mesurée à différents temps. La clairance de l’agent infectieux s’appuie ainsi sur l’évolution de la charge biologique mesurée au sein de la matrice ou d’un organe. Pour les modèles tumoraux, les lignées cellulaires utilisées sont B16F10 (mélanome) et PYB6 (sarcome).
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
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"J. Botham",
"E. Corsini",
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"M. Hamze",
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"Y. Qu",
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] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999997
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| 3.942703
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011DB975795A2F99BE9259140A301F1F20722D9A_p32
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011DB975795A2F99BE9259140A301F1F20722D9A
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sec[4]/p[0]
|
Le test TDAR en immunotoxicologie
| 4.359375
| -0.013889
|
biomedical
|
Study
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[
0.99853515625,
0.0003886222839355469,
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[
0.99658203125,
0.0022716522216796875,
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0.00010275840759277344
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La réponse thymo-dépendante concerne les antigènes protéiques et implique plusieurs acteurs de l’immunité, nécessitant donc une évaluation in vivo . Le test TDAR permet une évaluation fonctionnelle in vivo du système immunitaire de l’animal lorsque celui-ci reçoit un traitement expérimental. Pour évaluer cette réponse, un antigène fortement immunogène est injecté aux animaux selon un schéma vaccinal préalablement défini (une seule ou plusieurs immunisations), et la réponse immunitaire est appréciée par la quantification (par ELISA) des anticorps IgM et IgG qui sont produits spécifiquement contre l’antigène utilisé . Ce test permet de suivre la réponse humorale spécifique dans des conditions reproductibles de stimulation antigénique. C’est pourquoi le test TDAR est obligatoire selon la ligne directrice 443 de l’OCDE pour l’évaluation de produits chimiques qui ne sont pas soumis à d’autres règlementations comme c’est le cas pour les médicaments à usage humain et vétérinaire, les cosmétiques, les dispositifs médicaux, les substances radioactives, les produits agroalimentaires, les tissus d’origine humaine ou animale. Il est ensuite recommandé en première intention par la ligne directrice ICH S8 pour l’évaluation de l’immunotoxicité lorsque le produit testé cible les cellules de l’immunité, ou si une immunotoxicité est fortement suspectée par ailleurs ( Tableau 2 ). Il permet notamment de déceler des phénomènes d’immunodépression en cas de diminution de la réponse mais peut aussi être adapté pour révéler les immunostimulations (schéma vaccinal et doses différentes). Comme pour les autres techniques utilisées en immunotoxicité, différents paramètres doivent être déterminés pour effectuer un test TDAR.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
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"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
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"G.R. Burleson",
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"M. De La Morena",
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"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999997
| 3.149758
| 4.056372
| 3.118911
| 4.035827
| 0.010579
| 0.944857
| -0.002845
| 5.062243
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011DB975795A2F99BE9259140A301F1F20722D9A_p33
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[4]/sec[0]/p[0]
|
Choix de l’espèce
| 3.882813
| -0.301552
|
biomedical
|
Study
|
[
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[
0.91064453125,
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Le choix de l’espèce suit la ligne directrice ICH S8. Contrairement à l’homme, le chien et le singe, les rongeurs ne possèdent pas de système immunitaire fonctionnel à la naissance , il est donc recommandé d’utiliser des rongeurs âgés d’au moins 42 jours pour de tels tests. L’effectif par groupe et par sexe trouvé dans la littérature reprend les recommandations de la ligne directrice OPPTS 870.7800 , avec 8–10 pour les rongeurs, 5 pour les non rongeurs et 3 pour les primates non humains. Les groupes d’animaux utilisés dans un test TDAR sont en général au nombre de 5, incluant un groupe témoin négatif recevant le solvant de l’antigène, un groupe témoin positif recevant une molécule connue pour avoir un effet immunosuppresseur puissant comme le cyclophosphamide, la dexaméthasone ou la cyclosporine et trois groupes recevant la molécule à tester à différentes doses (faible, moyenne et élevée) .
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
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"B. Remandet",
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"J. Descotes",
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"A. Rooney",
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"M.M. Fort",
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"M.-S. Piche",
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"G. Reichmann",
"P.C. Ryan",
"R. Stebbings",
"M. Walker",
"H.G. Haggerty",
"T. Hartung",
"E. Corsini",
"C.J. Janeway",
"P. Travers",
"M. Walport",
"M.J. Shlomchik",
"P.W.F. Karmaus",
"A.L. Karmaus",
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"T.T. Kawabata",
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"J. van Bilsen",
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"A. Wolterbeek",
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"H. Lebrec",
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"A. López-Soto",
"M.I. Luster",
"S. Mahalingam",
"J. Peter",
"Z. Xu",
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"M. Ho",
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"K. Muthumani",
"P.L. Martin",
"S. Meunier",
"M. de Bourayne",
"M. Hamze",
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"M. De La Morena",
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"T.O. Harville",
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"R.A. Becker",
"T.M. Potter",
"B.W. Neun",
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"T. Rabadi",
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"A.J. Iqbal",
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"Thériaque",
"Thériaque",
"US EPA",
"US EPA",
"US EPA",
"J.G. Vos",
"J.A. Moore",
"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999997
| 2.805978
| 4.040545
| 3.054941
| 3.979949
| 0.015105
| 0.962277
| -0.001845
| 2.616367
| -3.700543
| 6.496394
| 1.001194
| 1.023437
| 0.054061
| 3.404069
|
clinical_guidance
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|
questions
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011DB975795A2F99BE9259140A301F1F20722D9A_p34
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[4]/sec[1]/p[0]
|
Choix de l’antigène
| 3.664063
| 1.516371
|
biomedical
|
Study
|
[
0.9970703125,
0.00022459030151367188,
0.0027618408203125
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[
0.82861328125,
0.169189453125,
0.0017986297607421875,
0.00033855438232421875
] |
Le choix d’un antigène thymo-dépendant est une étape critique dans l’élaboration du test TDAR. En effet, cet antigène va conditionner l’immunisation de l’animal mais aussi le dosage analytique (fixé au fond des puits de la plaque d’ELISA, il va être reconnu par les anticorps IgM et IgG présents dans l’échantillon à doser). Un antigène thymo-dépendant idéal à administrer doit être immunogène (sans besoin d’adjuvants), faible en endotoxines et utilisable chez différentes espèces animales . Le tableau 3 reprend les principales caractéristiques d’antigènes utilisés pour le test TDAR.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
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"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
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011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[4]/sec[1]/p[1]
|
Choix de l’antigène
| 4.292969
| 1.043623
|
biomedical
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Study
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[
0.99658203125,
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[
0.98291015625,
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Keyhole limpet hemocyanin (KLH) est une protéine de grande taille (4–8 MDa, 600–800 kDa par sous-unité), issue d’un mollusque marin ( Megathura crenulata ), qui transporte l’oxygène. KLH est l’antigène le plus couramment employé car il donne des résultats d’immunisation robustes chez les mammifères, peut être utilisé comme transporteur pour les haptènes ou en tant qu’adjuvant, est facilement accessible dans le commerce et permet l’évaluation de la réponse primaire (IgM) comme secondaire (IgG) par technique ELISA . Son inconvénient réside dans la présence potentielle d’une réactivité croisée au niveau des anticorps anti-KLH chez les primates non humains (NHP). En effet, l’épitope de KLH possède une structure proche de celui d’un antigène présent chez le parasite Schistosoma mansoni , qui a un taux d’infection élevé chez les NHP (environ 10 % chez les souches africaines) . Cette réactivité croisée peut donc rendre l’interprétation des résultats délicate car le modèle animal ayant rencontré le parasite présente une concentration d’anticorps plus élevée qu’un animal naïf. Dans ce cas, il n’est pas possible d’évaluer la fonction immunitaire à la suite d’une primo-immunisation à la KLH.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
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"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
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biomedical
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Les érythrocytes de mouton ( Sheep Red Blood Cells ou SRBC), qui présentent une très bonne immunogénicité , ont été historiquement le premier type d’antigène utilisé dans le test TDAR. Ils constituent l’antigène d’immunisation pour les tests TDAR dirigés contre les produits environnementaux (pesticides) et autres produits chimiques selon la ligne directrice 870.7800 de l’OPPTS . Ils sont moins employés dans le domaine pharmaceutique car ils ont une faible stabilité et une durée de conservation relativement brève. Le choix de la source d’approvisionnement constitue donc une étape critique dans l’élaboration d’un test TDAR utilisant cet antigène. De plus, les SRBC sont déconseillés pour immuniser les chiens car des réactions d’hypersensibilité ont été décrites . Enfin, la récupération des SRBC nécessite de sacrifier les animaux pour prélever la rate, contrairement aux autres antigènes.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
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"J.-J. Legrand",
"J. Descotes",
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"J. Botham",
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"E. Evans",
"D. Germolec",
"M. Holsapple",
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"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
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"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999998
| 3.136912
| 4.009753
| 2.980816
| 3.942872
| 0.022816
| 0.955605
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| 6.577944
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011DB975795A2F99BE9259140A301F1F20722D9A_p37
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011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[4]/sec[1]/p[3]
|
Choix de l’antigène
| 3.935547
| -1.517211
|
biomedical
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Other
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[
0.9951171875,
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[
0.35498046875,
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Le vaccin contre le tétanos ( tetanus toxoid ou TT) est une anatoxine de la bactérie Clostridium tetani , l’agent infectieux du tétanos . Pour le test TDAR, cet antigène peut être utilisé comme alternative à la KLH car il induit une réponse clinique plus visible (érythème, épaississement cutané, œdème) . La majorité des hommes et des primates utilisés comme animaux de laboratoire étant déjà vaccinée contre cette bactérie, il est important de confirmer le statut vaccinal d’un primate non humain avant immunisation. Un inconvénient est que la plupart des vaccins commercialisés contiennent un adjuvant (par exemple l’hydroxyde d’aluminium) qui peut entraîner une exacerbation de la réponse immunitaire. De ce fait, le TT est plutôt utilisé pour étudier la fonction de mémoire immunitaire (rappel vaccinal).
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
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"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
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"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
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"H. Lu",
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"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
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"G.R. Burleson",
"V.J. Johnson",
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"E. Corsini",
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"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
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"J. Descotes",
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"K. Mori",
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"J. van Bilsen",
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"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999995
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| 4.049052
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|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[4]/sec[1]/p[4]
|
Choix de l’antigène
| 4.273438
| -0.859906
|
biomedical
|
Study
|
[
0.99755859375,
0.0003981590270996094,
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[
0.88232421875,
0.1107177734375,
0.0064849853515625,
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La protéine HBsAg est un antigène de surface situé au niveau de l’enveloppe du virus de l’hépatite B. Sa présence dans le sérum du patient est un marqueur d’infection par ce virus. Par ses caractéristiques immunogènes, la protéine HBsAg fait partie de la composition du vaccin contre l’hépatite B . Cette protéine HBsAg est une alternative à l’utilisation de la KLH d’une part pour la facilité de son approvisionnement (vaccin) et d’autre part pour une utilisation plus sûre satisfaisant aux exigences règlementaires de qualité et de sécurité avant la mise sur le marché . De nos jours, cet antigène est devenu quasiment historique en raison d’une meilleure disponibilité de la KLH. La protéine HBsAg est moins rencontrée chez les NHP que le TT, elle est donc utilisable pour mimer une primo-infection avant l’étude des mécanismes de rappel. Par ailleurs, la réponse immunitaire est plus importante et moins variable qu’avec le TT.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
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"A. Pinsino",
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"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
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"W.J. Freebern",
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"G.R. Burleson",
"V.J. Johnson",
"R.W. Luebke",
"L. Burns-Naas",
"M. Pallardy",
"H.-C. Chen",
"E. Corsini",
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"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
"J.H. Dean",
"J.R. Hincks",
"B. Remandet",
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"J. Descotes",
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"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999996
| 3.140769
| 4.0181
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| 3.880337
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| 1.000922
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|
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011DB975795A2F99BE9259140A301F1F20722D9A_p39
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[4]/sec[1]/p[5]
|
Choix de l’antigène
| 2.541016
| 1.80517
|
biomedical
|
Other
|
[
0.98583984375,
0.0013818740844726562,
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[
0.0704345703125,
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Le bactériophage phiX174 (ΦX174) est un virus à ADN simple brin circulaire de la famille des Microviridae . Un des avantages de cet antigène est la possibilité de l’utiliser comme agent d’immunisation chez plusieurs espèces animales (mammifères et autres vertébrés). L’inconvénient majeur de ΦX174 est sa difficulté d’approvisionnement, cet antigène n’étant pas commercialisé . En conséquence, cela limite l’utilisation de ΦX174 aux études non cliniques.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
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"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999996
| 2.783127
| 4.032505
| 2.926098
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011DB975795A2F99BE9259140A301F1F20722D9A_p40
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[4]/sec[2]/p[0]
|
Choix de la dose et de la voie d’administration
| 2.580078
| -0.036331
|
biomedical
|
Study
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[
0.99072265625,
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[
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L’administration de l’antigène se fait par voie parentérale, avec des doses qui dépendent de l’antigène, de la voie et de l’espèce utilisés ( Tableau 4 ).
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
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"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999997
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011DB975795A2F99BE9259140A301F1F20722D9A_p41
|
011DB975795A2F99BE9259140A301F1F20722D9A
|
sec[4]/sec[3]/p[0]
|
Choix de la durée de traitement
| 4.199219
| -0.708654
|
biomedical
|
Study
|
[
0.99755859375,
0.000469207763671875,
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[
0.990234375,
0.00846099853515625,
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Bien que la ligne directrice ICH S8 recommande de réaliser une étude de 28 jours en moyenne, plusieurs critères tels que la demi-vie des anticorps IgM et IgG, les mécanismes résolutifs suivant l’immunisation mais aussi la nouvelle réponse à la suite de la deuxième immunisation, peuvent conditionner la durée, notamment lorsque la mémoire immunitaire est évaluée. Comme illustré dans la figure 1 , la deuxième exposition induit une réponse immunitaire plus efficace que la première, montrant l’importance de réaliser une étude longue afin de pouvoir observer cet effet. Le moment de l’immunisation est également un critère à prendre en compte dans l’élaboration du protocole d’étude. L’immunisation peut être réalisée une ou deux fois selon les besoins de l’étude. Par exemple, pour générer des contrôles positifs, une seule immunisation suffit car la réponse est déjà importante, tandis que pour évaluer la mémoire immunitaire, deux immunisations sont nécessaires . L’administration de la molécule à évaluer et du cyclophosphamide se fait au premier jour de l’étude. La figure 2 présente des exemples de protocole d’étude pour le test TDAR sur une durée de 28 jours. Dans ce cas, la première immunisation est réalisée à J7 chez les singes et à J14 chez les rongeurs . Pour une étude de plus longue durée (3 mois), deux immunisations sont réalisées afin d’évaluer les réponses primaire et secondaire, la deuxième immunisation étant effectuée 4 à 6 semaines après la première afin de laisser le taux d’anticorps diminuer . Les prélèvements sanguins se font en général tous les 7 jours à partir du premier jour d’immunisation.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
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"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
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| 0.999999
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011DB975795A2F99BE9259140A301F1F20722D9A
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sec[4]/sec[4]/p[0]
|
Choix de la méthode analytique
| 4.328125
| 1.429266
|
biomedical
|
Study
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[
0.99853515625,
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[
0.998046875,
0.0014495849609375,
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0.000080108642578125
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La méthode analytique doit permettre la quantification du taux d’anticorps dirigés contre l’antigène d’immunisation. La majorité des tests TDAR utilise une technique ELISA (directe, indirecte, par compétition ou en sandwich) mais on peut trouver dans la littérature l’électro-chimio-luminescence ou encore la technique Plaque-Forming Cell Assay (PFC) ( Tableau 5 ). Les tests ELISA sont ceux classiquement utilisés en immunologie. L’électro-chimio-luminescence implique la détection de la lumière produite par une réaction électrochimique, grâce au couplage de l’anticorps de détection avec un luminophore à base de ruthénium (Ru(bpy) 3 2+ ). Enfin, le PFC consiste à quantifier le nombre de plasmocytes dans la rate après immunisation (souris ou rat) par les SRBC . Quatre à cinq jours après immunisation par ces cellules, l’animal est sacrifié, les splénocytes sont isolés et mis en suspension dans du sérum de cochon d’Inde (contenant les facteurs du complément) avec les SRBC et une solution d’agar-agar. Cette suspension est incubée dans une boîte de Pétri pendant 3 heures à 37 °C. Les plasmocytes vont produire des anticorps IgM anti-SRBC qui diffusent dans la boîte de Pétri, reconnaissent l’antigène SRBC et s’y fixent. Ils vont ensuite changer de conformation et activer la cascade du complément. Le système du complément va induire la lyse des SRBC et la décoloration de la zone (appelée « plaque »). L’observation se fait au microscope et les plaques sont comptées. Cela permet de déterminer le « PFC », à savoir le nombre de cellules qui produisent des anticorps et donc de plaques par rate ou par million de splénocytes. Les avantages et inconvénients de ces trois méthodes analytiques sont repris dans le tableau 5 . La validation des méthodes intègre la précision évaluée par le coefficient de variation (CV) qui doit être inférieur à 30 %. Les techniques ELISA et ECL permettent plus facilement de respecter ce critère.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
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"C. Boisseau",
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"D. Germolec",
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"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
"S.C.M. Burleson",
"W.J. Freebern",
"F.G. Burleson",
"G.R. Burleson",
"V.J. Johnson",
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"M. Wuhrer",
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"C.F. Grant",
"E.A. Lefevre",
"B.V. Carr",
"H. Prentice",
"S. Gubbins",
"A.J. Pollard",
"C. Charreyre",
"B. Charleston",
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"D. Finco",
"M.M. Fort",
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"S.T. Parish",
"M.-S. Piche",
"D.M. Reed",
"G. Reichmann",
"P.C. Ryan",
"R. Stebbings",
"M. Walker",
"H.G. Haggerty",
"T. Hartung",
"E. Corsini",
"C.J. Janeway",
"P. Travers",
"M. Walport",
"M.J. Shlomchik",
"P.W.F. Karmaus",
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"R. Kaul",
"T.T. Kawabata",
"E.W. Evans",
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"S. Ito",
"T. Aida",
"H. Hattori",
"T. Kimura",
"T. Furukawa",
"K. Mori",
"A. Sanbuissho",
"T. Kawada",
"L.D. Koller",
"C.F. Kuper",
"J. van Bilsen",
"H. Cnossen",
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"Z.K. Ballas",
"J. Chinen",
"M. De La Morena",
"D. Kumararatne",
"T.O. Harville",
"P. Hesterberg",
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"S. McGhee",
"E.E. Perez",
"J. Raasch",
"R. Scherzer",
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"L. Peyton Myers",
"L.M. Plitnick",
"D.J. Herzyk",
"L.M. Plunkett",
"A.M. Kaplan",
"R.A. Becker",
"T.M. Potter",
"B.W. Neun",
"M.A. Dobrovolskaia",
"T. Rabadi",
"M.F. Brady",
"L. Richards",
"B. Erko",
"K. Ponpetch",
"S.J. Ryan",
"S. Liang",
"A.N. Rumianek",
"D.R. Greaves",
"ScienceDirect",
"R. Sharon",
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"A.M. Kask",
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"A.J. Iqbal",
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"Thériaque",
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"Thériaque",
"US EPA",
"US EPA",
"US EPA",
"J.G. Vos",
"J.A. Moore",
"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
|
fr
| 0.999996
| 3.208865
| 3.970069
| 3.42972
| 4.158458
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| 1.04887
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| 3.257241
|
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| 0.995276
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011DB975795A2F99BE9259140A301F1F20722D9A
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| 4.207031
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biomedical
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L’immunotoxicologie étudie le dysfonctionnement immunitaire à la suite d’une exposition à un xénobiotique. Cette branche récente de la toxicologie est de nos jours de plus en plus demandée dans l’évaluation de la sécurité de divers produits de consommation avant leur commercialisation, dont les médicaments (notamment les immunomodulateurs et les produits issus des biotechnologies). L’approche par palier permet d’évaluer un potentiel risque immunotoxique par des tests observationnels cliniques et biologiques, puis de confirmer cet effet par des tests fonctionnels si nécessaire. Le test fonctionnel de première intention en immunotoxicologie est le test TDAR qui évalue chez l’animal in vivo la capacité du système immunitaire à établir une réponse humorale thymo-dépendante après une immunisation par un antigène. Cette capacité est modifiée par les molécules immunotoxiques. L’analyse du test TDAR repose couramment sur la titration des anticorps IgG et IgM anti-KLH par technique ELISA. Bien que considéré comme le gold standard des tests fonctionnels en immunotoxicologie, le test TDAR ne dispose pas de protocole standardisé permettant aux laboratoires d’adapter leur procédure.
|
[
"Cathy Nguyen",
"Lars Petter Jordheim",
"W. Ai",
"H. Li",
"N. Song",
"L. Li",
"H. Chen",
"American College of Toxicology",
"S.E. Anderson",
"H.L. Shane",
"M. Auguste",
"D. Melillo",
"A. Corteggio",
"R. Marino",
"L. Canesi",
"A. Pinsino",
"P. Italiani",
"D. Boraschi",
"G. Bannish",
"C. Boisseau",
"S. Perrot",
"C. Bouchez",
"F. Gervais",
"R. Fleurance",
"B. Palate",
"J.-J. Legrand",
"J. Descotes",
"D.R. Boverhof",
"G. Ladics",
"B. Luebke",
"J. Botham",
"E. Corsini",
"E. Evans",
"D. Germolec",
"M. Holsapple",
"S.E. Loveless",
"H. Lu",
"J.W. van der Laan",
"K.L. White",
"Y. Yang",
"G.R. Burleson",
"F.G. Burleson",
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"J.H. Dean",
"J.H. Dean",
"M.L. Padarathsingh",
"T.R. Jerrells",
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"J.R. Hincks",
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"W.S. Helms",
"J.A. Mitchell",
"R. O’Lone",
"S.T. Parish",
"M.-S. Piche",
"D.M. Reed",
"G. Reichmann",
"P.C. Ryan",
"R. Stebbings",
"M. Walker",
"H.G. Haggerty",
"T. Hartung",
"E. Corsini",
"C.J. Janeway",
"P. Travers",
"M. Walport",
"M.J. Shlomchik",
"P.W.F. Karmaus",
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"T. Kawada",
"L.D. Koller",
"C.F. Kuper",
"J. van Bilsen",
"H. Cnossen",
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"A.J. Iqbal",
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"Thériaque",
"Thériaque",
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"US EPA",
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"J.G. Vos",
"J.A. Moore",
"W. Yao",
"M. Ding",
"L. Bao",
"Y. Zhao",
"D. Wang",
"Y. Li",
"Y. Qu",
"C. Hao"
] |
https://doi.org/10.1051/jbio/2022020
|
N/A
|
N/A
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medical_knowledge
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011DB975795A2F99BE9259140A301F1F20722D9A
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sec[5]/p[1]
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biomedical
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Study
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L’enjeu majeur pour l’évaluation de l’immunotoxicité dans les différents domaines (santé, agroalimentaire, chimie…) devrait être le remplacement d’animaux de laboratoire par des essais fiables et reproductibles utilisant du matériel biologique standardisé et facile d’accès comme des lignées cellulaires. De nouveaux tests permettent l’étude de tel ou tel paramètre ou lignée cellulaire de façon isolée , ce qui diminue l’utilisation des animaux tout en augmentant le nombre d’expériences à effectuer. Cependant, la corrélation entre les résultats des tests in vitro et la réalité in vivo n’est au mieux que partielle . Afin de garantir une pertinence biologique des tests, ceux-ci devraient intégrer un ensemble de cellules différentes représentées dans des proportions et des niveaux d’activité et d’activation similaires à ceux trouvés dans l’organisme, voire dans différents organes. Cela semble aujourd’hui une perspective difficile à atteindre, mais les technologies actuelles permettant l’élaboration et l’étude d’organoïdes, de sphéroïdes et de tissus bio-imprimés devraient permettre le développement d’outils pouvant remplacer du moins partiellement, petit à petit, l’emploi d’animaux dans ces tests. Une autre voie de recherche réside dans l’utilisation d’autres animaux, peut-être mieux tolérés au niveau sociétal, comme les moules et les oursins .
|
[
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https://doi.org/10.1051/jbio/2022020
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Le diagnostic précoce et l’instauration d’un traitement adapté sont les seuls garants d’un pronostic fonctionnel définitif optimal.
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[
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"K. Atarraf",
"M. Arroud",
"M. Rami",
"A. El Madi",
"A. Afifi",
"Y. Bouabdallah"
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https://doi.org/10.1016/S0929-693X(08)72414-X
|
N/A
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https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
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L’exanthème est défini comme une éruption cutanée érythémateuse et diffuse d’apparition brutale et transitoire (apparaissant en quelques heures et guérissant en quelques jours), révélatrice d’une affection sous-jacente. Souvent, il comporte des macules érythémateuses qui peuvent être associées à d’autres lésions élémentaires (papules, plaques, vésicules, purpura, voire nécrose). Les exanthèmes fébriles sont une cause fréquente de consultation et/ou d’hospitalisation. Ils s’observent au cours de nombreuses maladies infectieuses principalement d’origine virale mais également bactérienne (éruptions toxiniques, septicémie à méningocoque, infection à mycoplasmes, etc.). Néanmoins, devant tout exanthème fébrile, il faut garder à l’esprit la possibilité d’une étiologie médicamenteuse (toxidermie), d’un syndrome de Kawasaki ou plus rarement de maladie auto-immune ou hématologique.
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"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
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"J.P. Lacour"
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https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
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https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
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Dans un certain nombre de cas, l’exanthème adopte une présentation clinique stéréotypée, permettant d’évoquer l’agent étiologique responsable, généralement viral, et de définir le mode d’évolutivité des symptômes. Considérés à tort comme l’apanage des enfants, la plupart de ces exanthèmes infectieux s’observe également, avec une fréquence moindre, chez l’adulte et sont de ce fait parfois sous-diagnostiqués.
|
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"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999996
| 3.024651
| 4.028669
| 2.95174
| 3.7706
| -0.024786
| 1.019911
| 0.002357
| 2.172408
| -3.836774
| 3.789373
| -0.000009
| 0.028779
| -0.091101
| 4.57612
|
medical_knowledge
| 0.999702
|
questions
| 0.976599
| 0
| 0.999738
| 1
| 0.999998
| 1
| 0.999574
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p2
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[0]/p[2]
|
Introduction
| 1.87207
| 0.430739
|
biomedical
|
Other
|
[
0.96923828125,
0.01194000244140625,
0.01885986328125
] |
[
0.0154266357421875,
0.97998046875,
0.0009870529174804688,
0.0038433074951171875
] |
Malgré tout, la liste des étiologies infectieuses virales est longue et chaque agent infectieux n’est pas associé à un tableau clinique, en particulier dermatologique, stéréotypé.
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
"P. Parola",
"M. Grandadam",
"S. Fourcade",
"M. Oliver",
"P. Brouqui",
"F. Desruelles",
"M.Y. Maiga",
"F. Oberti",
"P. Cales",
"S.H. Han",
"A. Chantepie",
"P. Mauran",
"J.R. Lusson",
"M.C. Vaillant",
"A. Bozio",
"A.E. Silva",
"Y. Maeno",
"A. Hashmi",
"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999998
| 2.135787
| 4.116902
| 2.018599
| 3.190649
| -0.0057
| 1.017536
| 0.000571
| 5.117932
| -3.880826
| 4.984879
| 0.013464
| 0.025736
| 0.015556
| 4.503342
|
medical_knowledge
| 0.994737
|
questions
| 0.998396
| 0
| 0.999976
| 1
| 1
| 1
| 0.998741
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p3
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[0]/p[3]
|
Introduction
| 1.963867
| -1.132294
|
biomedical
|
Other
|
[
0.97900390625,
0.00881195068359375,
0.01197052001953125
] |
[
0.0120849609375,
0.98388671875,
0.0014200210571289062,
0.0027179718017578125
] |
La démarche diagnostique doit intégrer l’ensemble des éléments à notre disposition : épidémiologiques, cliniques (signes dermatologiques et non dermatologiques) et biologiques.
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
"P. Parola",
"M. Grandadam",
"S. Fourcade",
"M. Oliver",
"P. Brouqui",
"F. Desruelles",
"M.Y. Maiga",
"F. Oberti",
"P. Cales",
"S.H. Han",
"A. Chantepie",
"P. Mauran",
"J.R. Lusson",
"M.C. Vaillant",
"A. Bozio",
"A.E. Silva",
"Y. Maeno",
"A. Hashmi",
"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999997
| 2.136508
| 4.01339
| 2.106655
| 3.228501
| 0.001224
| 0.995341
| -0.001074
| -0.721183
| -2.062161
| 5.08054
| -0.005075
| 0.015935
| 0.389435
| 4.544411
|
clinical_guidance
| 0.893804
|
questions
| 0.997878
| 4
| 0.62919
| 1
| 0.999718
| 1
| 0.996091
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p4
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[1]/sec[0]/p[0]
|
Démarche diagnostique devant un exanthème
| 2.037109
| 0.593844
|
biomedical
|
Other
|
[
0.9287109375,
0.046783447265625,
0.0244140625
] |
[
0.0096893310546875,
0.966796875,
0.001277923583984375,
0.0223846435546875
] |
L’exanthème peut se définir comme une éruption érythémateuse diffuse aiguë généralisée. Cette définition ne préjuge pas de la lésion élémentaire ni de sa cause.
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
"P. Parola",
"M. Grandadam",
"S. Fourcade",
"M. Oliver",
"P. Brouqui",
"F. Desruelles",
"M.Y. Maiga",
"F. Oberti",
"P. Cales",
"S.H. Han",
"A. Chantepie",
"P. Mauran",
"J.R. Lusson",
"M.C. Vaillant",
"A. Bozio",
"A.E. Silva",
"Y. Maeno",
"A. Hashmi",
"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999995
| 2.311774
| 4.282269
| 2.061396
| 3.296918
| -0.02182
| 1.007487
| -0.001963
| 1.817375
| -4.368262
| 5.398806
| 0.019866
| 0.022164
| -0.007148
| 4.683772
|
medical_knowledge
| 0.996465
|
questions
| 0.996118
| 0
| 0.99975
| 1
| 0.999987
| 1
| 0.998754
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p5
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[1]/sec[0]/p[1]
|
Démarche diagnostique devant un exanthème
| 2.333984
| -0.01324
|
biomedical
|
Other
|
[
0.990234375,
0.005767822265625,
0.0038242340087890625
] |
[
0.171142578125,
0.81982421875,
0.0020008087158203125,
0.00688934326171875
] |
La démarche diagnostique doit donc s’appuyer sur une description soigneuse de l’éruption cutanée et un examen clinique complet. L’épidémiologie est également fondamentale dans cette démarche diagnostique ( Tableau 1 ).
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
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"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
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"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
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"B.W. McCrindle",
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"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
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"J.S. Bjorge Nelson",
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"L. Misery",
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"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
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"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999999
| 2.111119
| 3.963854
| 1.960534
| 2.934196
| -0.004854
| 0.957056
| -0.001292
| 0.646763
| -2.417016
| 5.194729
| 0.82616
| 0.054114
| 0.002767
| 4.80795
|
medical_knowledge
| 0.756049
|
questions
| 0.99116
| 0
| 0.990392
| 1
| 0.999899
| 1
| 0.992912
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p6
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[1]/sec[0]/p[2]
|
Démarche diagnostique devant un exanthème
| 3.119141
| -2.35141
|
biomedical
|
Other
|
[
0.99267578125,
0.004550933837890625,
0.002956390380859375
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[
0.01959228515625,
0.9765625,
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On peut aussi s’aider d’examens biologiques simples : numération–formule sanguine, plaquettes, C reactive protein (CRP), transaminases. Une lymphopénie et un syndrome mononucléosique sont plus en faveur d’une origine virale, alors que l’hyperéosinophilie orienterait davantage vers une étiologie médicamenteuse . En dehors d’un drug reaction with eosinophilia and systemic symptoms (DRESS), l’existence d’une cytolyse est un argument en faveur d’une éruption virale (rougeole, Epstein-Barr virus [EBV], cytomégalovirus [CMV], virus de l’immunodéficience humaine [VIH], etc.).
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
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"P. Poubeau",
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"A.E. Silva",
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"H. Kikuta",
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"T. Osato",
"D. Lipsker",
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"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
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"R. Gianotti",
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"N. Prose",
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"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
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"B. Bioulac-Sage",
"R. Gutzmer",
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"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999999
| 2.851897
| 4.006618
| 2.989635
| 4.035295
| -0.022852
| 0.949552
| -0.001272
| 0.525076
| -3.507047
| 0.152299
| 0.081759
| 0.998541
| 0.905506
| 3.629334
|
medical_knowledge
| 0.991927
|
questions
| 0.991405
| 0
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| 0.999742
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|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[1]/sec[0]/p[3]
|
Démarche diagnostique devant un exanthème
| 3.058594
| -0.801602
|
biomedical
|
Other
|
[
0.9951171875,
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[
0.0234375,
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L’interprétation des sérologies virales est délicate. On peut désormais isoler le virus en cause à partir de prélèvements cutanés (virus zona–varicelle [VZV]), ou muqueux (rougeole) ; on dispose des immunoglobulines M (IgM) dans certaines maladies virales qui rendent inutile l’attente d’une séroconversion IgG pour faire le diagnostic ; enfin, il existe des tests de diagnostic rapide pour certaines maladies (dengue par exemple).
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
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"P. Cales",
"S.H. Han",
"A. Chantepie",
"P. Mauran",
"J.R. Lusson",
"M.C. Vaillant",
"A. Bozio",
"A.E. Silva",
"Y. Maeno",
"A. Hashmi",
"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999995
| 2.863353
| 3.949385
| 2.972951
| 3.815971
| 0.016769
| 0.960508
| -0.00223
| 1.246405
| -5.392684
| 6.318065
| 0.037465
| 0.97468
| 0.22654
| 2.964466
|
medical_knowledge
| 0.99954
|
questions
| 0.991189
| 0
| 0.999916
| 1
| 0.999996
| 1
| 0.999901
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p8
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[1]/sec[0]/p[4]
|
Démarche diagnostique devant un exanthème
| 2.140625
| 0.799769
|
biomedical
|
Other
|
[
0.9765625,
0.0178375244140625,
0.00568389892578125
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[
0.02734375,
0.958984375,
0.0011930465698242188,
0.01263427734375
] |
La biopsie cutanée est inutile dans la majorité des cas car elle est non spécifique. Les résultats histologiques sont quasi similaires dans les éruptions d’origine virale ou médicamenteuse.
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
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"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
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"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999997
| 2.101216
| 4.066529
| 2.047491
| 3.10357
| -0.003986
| 0.97248
| -0.001563
| 1.881438
| -3.21676
| 4.398729
| 0.022944
| 0.065497
| -0.048357
| 4.778782
|
medical_knowledge
| 0.992231
|
questions
| 0.994043
| 0
| 0.999864
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| 0.999991
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| 0.999366
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p9
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[1]/sec[1]/p[0]
|
Diagnostics différentiels des exanthèmes viraux
| 2.142578
| 0.611684
|
biomedical
|
Other
|
[
0.98193359375,
0.00745391845703125,
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[
0.0177154541015625,
0.978515625,
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Les étiologies principales des exanthèmes sont les infections virales et les toxidermies. Mais d’autres infections (bactériennes, rarement parasitaire telle que la toxoplasmose) et certaines maladies de système sont des causes d’exanthème. Chez l’enfant, les causes virales sont plus fréquentes .
|
[
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"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
"P. Parola",
"M. Grandadam",
"S. Fourcade",
"M. Oliver",
"P. Brouqui",
"F. Desruelles",
"M.Y. Maiga",
"F. Oberti",
"P. Cales",
"S.H. Han",
"A. Chantepie",
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"J.R. Lusson",
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"A. Bozio",
"A.E. Silva",
"Y. Maeno",
"A. Hashmi",
"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999995
| 2.325299
| 3.960915
| 2.565237
| 3.346696
| -0.005136
| 0.976436
| 0.00211
| 2.276722
| -3.8419
| 4.937863
| 0.033759
| -0.017234
| 0.192163
| 4.784666
|
medical_knowledge
| 0.999499
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questions
| 0.979232
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|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[1]/sec[1]/p[1]
|
Diagnostics différentiels des exanthèmes viraux
| 2.300781
| -0.302435
|
biomedical
|
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|
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[
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Les meilleurs arguments en faveur d’une toxidermie sont : • l’existence d’un prurit ; • le polymorphisme lésionnel ; • l’absence d’énanthème ; • l’absence ou la discrétion de la fièvre ; • l’existence d’une hyperéosinophilie .
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
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"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
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"M. Lalande",
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"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
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"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999996
| 2.315163
| 4.034103
| 2.573405
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| 1.040753
| 4.471337
|
medical_knowledge
| 0.875136
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questions
| 0.996706
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0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[1]/sec[1]/p[2]
|
Diagnostics différentiels des exanthèmes viraux
| 2.423828
| -2.336669
|
biomedical
|
Other
|
[
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[
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Les meilleurs arguments en faveur de l’origine virale sont : • épidémiologiques (jeune âge, notion de contage, période épidémique, absence de vaccination) ; • cliniques (énanthème associé, conjonctivite, absence de prurit, arthralgies, myalgies, fièvre, polyadénopathies, symptômes respiratoires ou digestifs) ; • biologiques (lymphopénie, syndrome mononucléosique, thrombopénie).
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
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"S. Matsumoto",
"T. Osato",
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"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999997
| 2.619254
| 3.994579
| 2.999863
| 3.895833
| 0.006862
| 0.976857
| 0.000275
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| -3.445192
| 1.481797
| -0.041363
| 0.002809
| 1.167028
| 4.544188
|
medical_knowledge
| 0.873358
|
questions
| 0.997206
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| 0.999891
| 1
| 0.999764
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|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[1]/sec[1]/p[3]
|
Diagnostics différentiels des exanthèmes viraux
| 1.991211
| 1.281823
|
biomedical
|
Other
|
[
0.98291015625,
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[
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Les étiologies des exanthèmes maculopapuleux et vésiculobulleux sont dominées par les infections virales.
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
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"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
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"A. Hashmi",
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"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
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"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
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"R. Gutzmer",
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"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999998
| 1.989049
| 4.366971
| 2.094635
| 3.529049
| -0.015202
| 1.014504
| -0.001822
| 4.044153
| -4.689998
| 4.568834
| -0.005373
| -0.022517
| 0.031276
| 4.346069
|
medical_knowledge
| 0.99554
|
questions
| 0.988127
| 0
| 0.999965
| 1
| 0.999995
| 1
| 0.997456
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p13
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[1]/sec[1]/p[4]
|
Diagnostics différentiels des exanthèmes viraux
| 4.074219
| -2.372507
|
biomedical
|
Study
|
[
0.9970703125,
0.0015592575073242188,
0.0012378692626953125
] |
[
0.904296875,
0.07635498046875,
0.0179901123046875,
0.0015344619750976562
] |
La présence d’un purpura doit faire envisager avant tout certains diagnostics d’urgence tels qu’une méningococcémie ou une fièvre hémorragique virale. Néanmoins, un purpura peut être banal au cours d’une éruption maculopapuleuse, notamment au niveau des membres inférieurs. Une étude italienne publiée en 2012 s’est penchée sur le diagnostic étiologique, souvent difficile, des exanthèmes atypiques . Elle a inclus 260 patients présentant ce type de manifestations cutanées (dont 108 enfants). Le but de cette étude était d’établir une corrélation entre le tableau clinique et une origine infectieuse ou médicamenteuse. Il est apparu, entre autres, que la grande majorité des éruptions à caractère purpurique était d’origine infectieuse (avec une majorité d’étiologie virale). L’existence d’un énanthème était aussi un élément pour une origine infectieuse, et là encore le caractère purpurique de ce dernier était dans 80 % des cas associé à une étiologie infectieuse. On peut retenir de ce travail que le caractère purpurique de l’exanthème et/ou de l’énanthème serait vraisemblablement un élément en faveur de l’étiologie infectieuse.
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
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"S. Aberle",
"H. Holzmann",
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"K. Ueda",
"K. Okada",
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"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
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"J.L. Sillivan",
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"G. Lange",
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"C. Aquilina",
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"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
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"M.Y. Maiga",
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"S.H. Han",
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"A. Bozio",
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"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
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"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
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"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
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"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999997
| 3.063719
| 3.965216
| 2.98498
| 3.852732
| 0.007068
| 1.014144
| 0.002391
| 4.604835
| -2.44524
| 2.911785
| 0.982875
| 0.086458
| 0.005064
| 1.767511
|
research_findings
| 0.831394
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questions
| 0.895136
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| 0.99815
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| 0.999101
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0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p14
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[2]/sec[0]/sec[0]/p[0]
|
Varicelle
| 2.255859
| -1.844748
|
biomedical
|
Other
|
[
0.978515625,
0.007282257080078125,
0.01422882080078125
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[
0.0252227783203125,
0.97021484375,
0.0008983612060546875,
0.0038089752197265625
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La varicelle est la primo-infection avec le VZV. L’incidence de la maladie est plus élevée au printemps. Neuf enfants sur dix auront eu la varicelle à l’âge de 10ans. La varicelle est très contagieuse, sa transmission interhumaine se fait surtout par voie aérienne. La contagiosité s’étend de un à deux jours avant le début de l’éruption et jusqu’à la disparition des vésicules.
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
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"L. Cotte",
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"G. Guillet",
"J. Maleville",
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"O. Jonquet",
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"N. Prose",
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"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
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"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999996
| 2.766191
| 3.950466
| 2.844569
| 3.423883
| 0.027255
| 0.96655
| 0.001453
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| 6.637084
| 1.009871
| 0.787194
| -0.096815
| 4.648169
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medical_knowledge
| 0.998967
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tasks
| 0.848145
| 0
| 0.999898
| 1
| 0.999997
| 1
| 0.999206
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0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p15
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[2]/sec[0]/sec[0]/p[1]
|
Varicelle
| 3.185547
| -0.338414
|
biomedical
|
Other
|
[
0.87744140625,
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[
0.0633544921875,
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0.08099365234375
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L’incubation est de 14jours en moyenne. Les prodromes (fièvre, céphalées) sont généralement peu importants. Un exanthème érythématomaculeux prurigineux intéressant principalement le tronc précède l’apparition des vésicules. Les papules puis les vésicules apparaissent initialement à la partie supérieure du corps et intéressent notamment le cuir chevelu. Le reste du corps est atteint avec une progression céphalocaudale des lésions. Il existe un énanthème associé avec des érosions postvésiculeuses retrouvées également dans la cavité buccale (vésicules le plus souvent rompues lors de l’examen de la cavité buccale du fait de leur fragilité). Les muqueuses génitales peuvent également être touchées. Les vésicules ombiliquées se troublent puis évoluent vers une croûte.
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
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"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
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"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
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"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
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"J.C. Nicolas",
"G. Lange",
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"J.R. Lusson",
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"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
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"O. Jonquet",
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"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
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"M. Lalande",
"D. Bessis",
"J.D. Cherry",
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"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
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"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999998
| 2.779042
| 3.97014
| 3.089781
| 3.897458
| -0.000547
| 1.005618
| -0.000096
| -0.963247
| -2.096577
| 5.288056
| 1.003244
| 0.027551
| -0.080256
| 4.900638
|
medical_knowledge
| 0.959647
|
questions
| 0.980555
| 0
| 0.999861
| 1
| 0.999985
| 1
| 0.999611
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p16
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[2]/sec[0]/sec[0]/p[2]
|
Varicelle
| 1.932617
| -1.723617
|
biomedical
|
Other
|
[
0.87939453125,
0.006649017333984375,
0.114013671875
] |
[
0.06549072265625,
0.93212890625,
0.0009188652038574219,
0.001445770263671875
] |
Plusieurs poussées se succèdent sur trois à six jours précédées et accompagnées inconstamment de fièvre entraînant la coexistence d’éléments d’âges différents (il s’agissait autrefois d’un élément de diagnostic différentiel de la variole, une seule poussée dans cette dernière).
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
"P. Parola",
"M. Grandadam",
"S. Fourcade",
"M. Oliver",
"P. Brouqui",
"F. Desruelles",
"M.Y. Maiga",
"F. Oberti",
"P. Cales",
"S.H. Han",
"A. Chantepie",
"P. Mauran",
"J.R. Lusson",
"M.C. Vaillant",
"A. Bozio",
"A.E. Silva",
"Y. Maeno",
"A. Hashmi",
"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999997
| 2.185784
| 3.892072
| 2.305892
| 3.211785
| 0.020803
| 0.958566
| 0.001023
| 1.669803
| -4.173038
| 5.580185
| 0.985969
| -0.051475
| -0.154075
| 4.080857
|
medical_knowledge
| 0.996238
|
questions
| 0.951134
| 0
| 0.999912
| 1
| 0.999998
| 1
| 0.99964
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p17
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[2]/sec[0]/sec[0]/p[3]
|
Varicelle
| 3.037109
| -0.580754
|
biomedical
|
Other
|
[
0.994140625,
0.0029087066650390625,
0.0028820037841796875
] |
[
0.06732177734375,
0.92919921875,
0.0008759498596191406,
0.0023860931396484375
] |
La confirmation diagnostique n’est pas nécessaire dans les formes typiques non compliquées. Elle repose sur la sérologie (détection d’IgM, séroconversion IgG) et/ou la mise en évidence par polymerase chain reaction (PCR) du VZV dans le liquide d’une vésicule (culture de la ponction d’une vésicule possible également).
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
"P. Parola",
"M. Grandadam",
"S. Fourcade",
"M. Oliver",
"P. Brouqui",
"F. Desruelles",
"M.Y. Maiga",
"F. Oberti",
"P. Cales",
"S.H. Han",
"A. Chantepie",
"P. Mauran",
"J.R. Lusson",
"M.C. Vaillant",
"A. Bozio",
"A.E. Silva",
"Y. Maeno",
"A. Hashmi",
"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999998
| 2.686011
| 3.999742
| 2.907354
| 4.021281
| -0.022089
| 0.949755
| -0.002321
| 1.15706
| -4.726665
| 6.208843
| 0.092697
| 1.076597
| 0.109774
| 4.559854
|
medical_knowledge
| 0.986271
|
questions
| 0.993305
| 0
| 0.999744
| 1
| 0.999987
| 1
| 0.999696
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p18
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[2]/sec[0]/sec[0]/sec[0]/p[0]
|
Complications de la varicelle
| 1.919922
| -1.118172
|
biomedical
|
Other
|
[
0.96875,
0.0158538818359375,
0.015594482421875
] |
[
0.01251983642578125,
0.9814453125,
0.0010480880737304688,
0.00518035888671875
] |
La varicelle est plus profuse et se complique plus volontiers chez l’adolescent et l’adulte ; la survenue d’une varicelle chez l’immunodéprimé expose à des complications (neurologiques, hépatiques, pulmonaires) plus fréquentes et plus sévères.
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
"P. Parola",
"M. Grandadam",
"S. Fourcade",
"M. Oliver",
"P. Brouqui",
"F. Desruelles",
"M.Y. Maiga",
"F. Oberti",
"P. Cales",
"S.H. Han",
"A. Chantepie",
"P. Mauran",
"J.R. Lusson",
"M.C. Vaillant",
"A. Bozio",
"A.E. Silva",
"Y. Maeno",
"A. Hashmi",
"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999998
| 2.346327
| 3.968059
| 2.632023
| 3.408413
| 0.009088
| 0.959894
| 0.001884
| -0.260682
| -4.433998
| 6.2444
| -0.011203
| -0.008733
| 0.057931
| 4.968829
|
medical_knowledge
| 0.998567
|
questions
| 0.748602
| 0
| 0.999943
| 1
| 0.999998
| 1
| 0.999337
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p19
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[2]/sec[0]/sec[0]/sec[0]/p[1]
|
Complications de la varicelle
| 2.621094
| -1.129125
|
biomedical
|
Other
|
[
0.98828125,
0.004909515380859375,
0.006671905517578125
] |
[
0.1356201171875,
0.85888671875,
0.001155853271484375,
0.0041351318359375
] |
La varicelle néonatale, secondaire à la survenue d’une varicelle maternelle entre j−5 et j+2 de l’accouchement, est associée à une mortalité élevée de 20 à 30 %, en raison de l’absence de transmission d’anticorps maternels.
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
"P. Parola",
"M. Grandadam",
"S. Fourcade",
"M. Oliver",
"P. Brouqui",
"F. Desruelles",
"M.Y. Maiga",
"F. Oberti",
"P. Cales",
"S.H. Han",
"A. Chantepie",
"P. Mauran",
"J.R. Lusson",
"M.C. Vaillant",
"A. Bozio",
"A.E. Silva",
"Y. Maeno",
"A. Hashmi",
"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999997
| 2.347813
| 4.065396
| 2.881348
| 3.915819
| -0.011031
| 1.02948
| -0.000459
| 4.434311
| -2.362863
| 5.279565
| 0.985046
| -0.016866
| -0.001819
| 4.435485
|
medical_knowledge
| 0.980918
|
tasks
| 0.979552
| 0
| 0.999984
| 1
| 0.999999
| 1
| 0.999522
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p20
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[2]/sec[0]/sec[0]/sec[0]/p[2]
|
Complications de la varicelle
| 2.785156
| -0.812253
|
biomedical
|
Other
|
[
0.9873046875,
0.007091522216796875,
0.005397796630859375
] |
[
0.0217132568359375,
0.97265625,
0.000762939453125,
0.00487518310546875
] |
À ne pas confondre avec la varicelle congénitale, qui est secondaire à la survenue d’une varicelle maternelle avant la quatrième semaine de grossesse : l’infection fœtale par le VZV est à l’origine de cicatrices cutanées déprimées, achromiques ou pigmentées, de microphtalmie, de cataracte, de choriorétinite, de microcéphalie, de retard mental, d’hypoplasie d’un membre et de décès précoce.
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
"P. Parola",
"M. Grandadam",
"S. Fourcade",
"M. Oliver",
"P. Brouqui",
"F. Desruelles",
"M.Y. Maiga",
"F. Oberti",
"P. Cales",
"S.H. Han",
"A. Chantepie",
"P. Mauran",
"J.R. Lusson",
"M.C. Vaillant",
"A. Bozio",
"A.E. Silva",
"Y. Maeno",
"A. Hashmi",
"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999997
| 2.899885
| 4.02648
| 3.089914
| 3.970722
| 0.002783
| 0.988368
| -0.001448
| 0.984969
| -2.585731
| 5.517799
| 1.008492
| 0.77299
| 1.025539
| 4.525456
|
medical_knowledge
| 0.998949
|
tasks
| 0.555073
| 0
| 0.999909
| 1
| 0.999996
| 1
| 0.999617
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p21
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[2]/sec[0]/sec[0]/sec[0]/p[3]
|
Complications de la varicelle
| 1.236328
| -0.897584
|
other
|
Other
|
[
0.38623046875,
0.0162353515625,
0.59765625
] |
[
0.00983428955078125,
0.98779296875,
0.00080108642578125,
0.0015659332275390625
] |
Après la 25 e semaine de grossesse, le risque est celui d’un zona dans l’enfance .
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
"P. Parola",
"M. Grandadam",
"S. Fourcade",
"M. Oliver",
"P. Brouqui",
"F. Desruelles",
"M.Y. Maiga",
"F. Oberti",
"P. Cales",
"S.H. Han",
"A. Chantepie",
"P. Mauran",
"J.R. Lusson",
"M.C. Vaillant",
"A. Bozio",
"A.E. Silva",
"Y. Maeno",
"A. Hashmi",
"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999997
| 1.919719
| 4.623882
| 1.774888
| 3.195476
| -0.022336
| 1.05091
| 0.003972
| 0.473907
| -1.357227
| 3.435632
| 0.972459
| 0.005466
| 0.038975
| 4.267311
|
medical_knowledge
| 0.997715
|
tasks
| 0.925986
| 0
| 0.999637
| 1
| 0.999978
| 1
| 0.998251
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p22
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[2]/sec[0]/sec[0]/sec[0]/p[4]
|
Complications de la varicelle
| 3.652344
| -1.313504
|
biomedical
|
Other
|
[
0.9716796875,
0.0255279541015625,
0.00269317626953125
] |
[
0.09930419921875,
0.88818359375,
0.0037975311279296875,
0.008575439453125
] |
Les complications intrinsèques sont assez rares chez l’enfant (pneumonie, méningite, ataxie secondaire à une cérébellite), mais les complications cutanées bactériennes sont au premier plan, en particulier chez l’enfant de moins de 4ans. Un enfant ayant une hyperthermie persistante au cours d’une varicelle doit être soigneusement examiné à la recherche d’une surinfection cutanée bactérienne, à staphylocoque doré (tableau d’impétigos bulleux ou de lésions nécrotiques multiples) ou à streptocoque bêtahémolytique (tableau de dermohypodermite bactérienne pouvant évoluer vers l’abcédation ou au pire une fasciite nécrosante) . Le rôle des traitements locaux a été documenté et plus particulièrement celui du talc comme facteur des plus graves complications infectieuses (à proscrire !).
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
"P. Parola",
"M. Grandadam",
"S. Fourcade",
"M. Oliver",
"P. Brouqui",
"F. Desruelles",
"M.Y. Maiga",
"F. Oberti",
"P. Cales",
"S.H. Han",
"A. Chantepie",
"P. Mauran",
"J.R. Lusson",
"M.C. Vaillant",
"A. Bozio",
"A.E. Silva",
"Y. Maeno",
"A. Hashmi",
"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999998
| 3.010179
| 4.014668
| 3.032387
| 3.921422
| 0.001252
| 1.005392
| -0.00149
| -0.512509
| -3.065706
| 4.929341
| 1.007453
| 0.044522
| 0.198858
| 4.410203
|
medical_knowledge
| 0.954029
|
tasks
| 0.984562
| 0
| 0.999399
| 1
| 0.999965
| 1
| 0.9997
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p23
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[2]/sec[0]/sec[0]/sec[1]/p[0]
|
Traitement
| 2.789063
| -2.866852
|
biomedical
|
Other
|
[
0.927734375,
0.0623779296875,
0.00981903076171875
] |
[
0.0080413818359375,
0.984375,
0.000469207763671875,
0.007167816162109375
] |
Le traitement chez l’enfant immunocompétent est symptomatique (soins d’hygiène simples sans recourir de façon systématique et prolongée aux antiseptiques locaux, trop vite irritants ; paracétamol et antihistaminique). Le traitement fait appel à l’aciclovir chez l’enfant immunodéprimé ou dans la varicelle congénitale . Enfin, devant un tableau de dermohypodermite bactérienne invasive du petit enfant, un traitement antibiotique intraveineux doit être rapidement débuté en milieu hospitalier.
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
"P. Parola",
"M. Grandadam",
"S. Fourcade",
"M. Oliver",
"P. Brouqui",
"F. Desruelles",
"M.Y. Maiga",
"F. Oberti",
"P. Cales",
"S.H. Han",
"A. Chantepie",
"P. Mauran",
"J.R. Lusson",
"M.C. Vaillant",
"A. Bozio",
"A.E. Silva",
"Y. Maeno",
"A. Hashmi",
"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999998
| 2.983371
| 3.979759
| 3.065351
| 3.938244
| 0.035235
| 1.018187
| -0.002567
| -2.289313
| -2.027708
| 4.479203
| -0.006918
| 0.092944
| -0.084404
| 3.824907
|
clinical_guidance
| 0.963317
|
tasks
| 0.994545
| 0
| 0.675647
| 1
| 0.999198
| 1
| 0.999549
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p24
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[2]/sec[0]/sec[0]/sec[1]/p[1]
|
Traitement
| 2.386719
| -3.79193
|
biomedical
|
Other
|
[
0.92578125,
0.062408447265625,
0.01177215576171875
] |
[
0.01007080078125,
0.9794921875,
0.0005621910095214844,
0.009918212890625
] |
L’utilisation d’aspirine est totalement contre-indiquée pouvant être responsable du syndrome de Reye (encéphalopathie aiguë avec atteinte hépatique sévère). L’utilisation d’anti-inflammatoires non stéroïdiens (AINS) est aussi à éviter pouvant favoriser les complications à type de surinfections bactériennes cutanées.
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
"P. Parola",
"M. Grandadam",
"S. Fourcade",
"M. Oliver",
"P. Brouqui",
"F. Desruelles",
"M.Y. Maiga",
"F. Oberti",
"P. Cales",
"S.H. Han",
"A. Chantepie",
"P. Mauran",
"J.R. Lusson",
"M.C. Vaillant",
"A. Bozio",
"A.E. Silva",
"Y. Maeno",
"A. Hashmi",
"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999996
| 2.416131
| 4.010467
| 2.894782
| 3.960395
| -0.006946
| 0.977779
| -0.003745
| -2.294164
| -3.837044
| 4.744755
| -0.073946
| 1.030879
| 0.110228
| 4.595603
|
drug_information
| 0.931527
|
questions
| 0.983873
| 0
| 0.991827
| 1
| 0.999906
| 1
| 0.999717
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p25
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[2]/sec[0]/sec[0]/sec[1]/p[2]
|
Traitement
| 2.488281
| -0.309961
|
biomedical
|
Other
|
[
0.97509765625,
0.00542449951171875,
0.0194091796875
] |
[
0.051605224609375,
0.9453125,
0.0008096694946289062,
0.0025177001953125
] |
Il faut garder à l’esprit que le zona (lié à la récurrence du virus VZV) de l’enfant n’est pas une situation exceptionnelle et son évolution est généralement peu douloureuse et bénigne. Le recours à des investigations complémentaires et à un traitement spécifique n’est habituellement pas nécessaire, sauf dans le cas d’un zona ophtalmique ou en présence d’atypies cliniques et/ou d’extension des vésicules en dehors du métamère primitivement atteint .
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
"P. Parola",
"M. Grandadam",
"S. Fourcade",
"M. Oliver",
"P. Brouqui",
"F. Desruelles",
"M.Y. Maiga",
"F. Oberti",
"P. Cales",
"S.H. Han",
"A. Chantepie",
"P. Mauran",
"J.R. Lusson",
"M.C. Vaillant",
"A. Bozio",
"A.E. Silva",
"Y. Maeno",
"A. Hashmi",
"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999998
| 2.980701
| 3.952515
| 2.973111
| 3.929148
| -0.015671
| 1.015092
| -0.000987
| -0.131774
| -2.977227
| 3.944507
| 0.078125
| 0.595915
| -0.005188
| 4.073795
|
medical_knowledge
| 0.984459
|
tasks
| 0.986768
| 0
| 0.998518
| 1
| 0.999971
| 1
| 0.999758
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p26
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[2]/sec[0]/sec[1]/p[0]
|
Syndrome pieds–mains–bouche
| 2.001953
| -1.163446
|
biomedical
|
Other
|
[
0.9677734375,
0.00762176513671875,
0.0247039794921875
] |
[
0.01434326171875,
0.982421875,
0.0007662773132324219,
0.0025196075439453125
] |
Le syndrome pieds–mains–bouche est un exanthème vésiculeux. Cet exanthème viral concerne essentiellement les enfants (de moins de 10ans) bien que des transmissions intrafamiliales soient souvent rapportées, et survient sous la forme de petites épidémies (crèches). Il s’agit d’une affection très contagieuse avec transmission interhumaine orale ou orofécale.
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
"P. Parola",
"M. Grandadam",
"S. Fourcade",
"M. Oliver",
"P. Brouqui",
"F. Desruelles",
"M.Y. Maiga",
"F. Oberti",
"P. Cales",
"S.H. Han",
"A. Chantepie",
"P. Mauran",
"J.R. Lusson",
"M.C. Vaillant",
"A. Bozio",
"A.E. Silva",
"Y. Maeno",
"A. Hashmi",
"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999996
| 2.77959
| 4.005572
| 2.900072
| 3.547189
| 0.011169
| 1.016776
| 0.002994
| 0.048718
| -3.915212
| 5.983466
| 0.972189
| -0.055576
| -0.043101
| 4.66423
|
medical_knowledge
| 0.996457
|
tasks
| 0.92137
| 0
| 0.99961
| 1
| 0.999987
| 1
| 0.999102
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p27
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[2]/sec[0]/sec[1]/p[1]
|
Syndrome pieds–mains–bouche
| 2.474609
| -0.265181
|
biomedical
|
Other
|
[
0.98974609375,
0.0038299560546875,
0.006343841552734375
] |
[
0.05230712890625,
0.94384765625,
0.0009036064147949219,
0.0030269622802734375
] |
En France, ce syndrome est lié à une infection à coxsackie A16 dans la grande majorité des cas (plus rarement aux coxsackies A4, A5, A6, A7, A9, A10, B1, B2, B3 ou B5). Des formes épidémiques graves ont été rapportées, principalement en Asie et en Australie, avec l’entérovirus 71 (complications essentiellement neurologiques) .
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
"P. Parola",
"M. Grandadam",
"S. Fourcade",
"M. Oliver",
"P. Brouqui",
"F. Desruelles",
"M.Y. Maiga",
"F. Oberti",
"P. Cales",
"S.H. Han",
"A. Chantepie",
"P. Mauran",
"J.R. Lusson",
"M.C. Vaillant",
"A. Bozio",
"A.E. Silva",
"Y. Maeno",
"A. Hashmi",
"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999996
| 2.08505
| 4.014605
| 2.978103
| 3.830759
| 0.007309
| 1.011172
| 0.000691
| 5.169999
| -4.769318
| 3.350292
| 0.916806
| 0.063756
| 0.519832
| 3.97566
|
medical_knowledge
| 0.983786
|
questions
| 0.890454
| 0
| 0.999978
| 1
| 0.999999
| 1
| 0.999594
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4_p28
|
0138CF4BD08E363A8D86EAC357B27ACD8494BCF4
|
sec[0]/sec[2]/sec[0]/sec[1]/p[2]
|
Syndrome pieds–mains–bouche
| 3.210938
| 0.911631
|
biomedical
|
Other
|
[
0.9921875,
0.004177093505859375,
0.0034618377685546875
] |
[
0.0638427734375,
0.93115234375,
0.0014553070068359375,
0.003582000732421875
] |
À la différence de la plupart des exanthèmes peu spécifiques associés aux entérovirus, le syndrome pieds–mains–bouche adopte une clinique caractéristique permettant en règle un diagnostic étiologique. La confirmation du diagnostic par prélèvement viral n’est de ce fait habituellement pas nécessaire . Celui-ci peut être établi par l’isolement du virus dans les vésicules cutanées surtout et/ou sur le pharynx et dans les selles par cultures cellulaires ou inoculation au souriceau et par l’ascension du taux des anticorps à deux prélèvements à dix jours d’intervalle.
|
[
"C. Fleuret",
"P. Plantin",
"E. Caumes",
"E. Caumes",
"T.B. Fitzpatrick",
"R.A. Johnson",
"S. Aractingi",
"J.C. Roujeau",
"F. Drago",
"B. Kellner",
"L. Kitai",
"C. Léauté-labrèze",
"U. Heininger",
"J.F. Seward",
"P. Gillard",
"M. de la Brassine",
"C.C. Huang",
"C.C. Liu",
"Y.C. Chang",
"R. Osterback",
"T. Vuorinen",
"M. Linna",
"P. Susi",
"T. Hyypiä",
"M. Waris",
"G.C. Clementz",
"A.J. Mancini",
"V. Bernier",
"C. Labrèze",
"F. Bury",
"A. Taïeb",
"J.L. Davia",
"P.H. Bel",
"V.Z. Ninet",
"M.A. Bracho",
"F. González-Candelas",
"A. Salazar",
"C. Baudon",
"J.P. Stahl",
"D. Salmon",
"F. Bruneel",
"E. Caumes",
"F. Freymuth",
"J.P. Bru",
"S. Kasper",
"F. Allerberger",
"S. Aberle",
"H. Holzmann",
"M. Redlberger",
"E. Daghofer",
"K. Kusuhara",
"K. Ueda",
"K. Okada",
"M. Yoshida",
"K. Fukui",
"T. Orita",
"P. Pruksananonda",
"C.B. Hall",
"R.A. Insel",
"K. McIntyre",
"P.E. Pellett",
"C.E. Long",
"C. Bialecki",
"H.M. Feder",
"J.M. Grant-Kels",
"A. Etienne",
"M. Harms",
"M. Harms",
"R. Feldmann",
"J.H. Saurat",
"S. Aractingi",
"K. Luzuriaga",
"J.L. Sillivan",
"J.C. Nicolas",
"G. Lange",
"B.O. Linhardt",
"K. Weisman",
"K. Ulrich",
"C. Aquilina",
"R. Viraben",
"F. Drago",
"M.G. Aragone",
"C. Lugani",
"A. Rebora",
"J.E. Froeschle",
"P. Feorino",
"H. Gelfand",
"A. Kogon",
"I. Spigland",
"T.E. Forthingham",
"L. Evelback",
"C. Williams",
"C. Hall",
"J.D. Cherry",
"P. Gérardin",
"S. Ernould",
"G. Borgherini",
"P. Poubeau",
"A. Jossaume",
"A. Gouix",
"L. Cotte",
"A. Michault",
"D. Bandyopadhyay",
"S.K. Ghosh",
"F. Simon",
"P. Parola",
"M. Grandadam",
"S. Fourcade",
"M. Oliver",
"P. Brouqui",
"F. Desruelles",
"M.Y. Maiga",
"F. Oberti",
"P. Cales",
"S.H. Han",
"A. Chantepie",
"P. Mauran",
"J.R. Lusson",
"M.C. Vaillant",
"A. Bozio",
"A.E. Silva",
"Y. Maeno",
"A. Hashmi",
"J.F. Smallborn",
"E.D. Silverman",
"B.W. McCrindle",
"H. Kikuta",
"S. Matsumoto",
"T. Osato",
"D. Lipsker",
"J.H. Saurat",
"A. Taïeb",
"P. Plantin",
"P. du Pasquier",
"G. Guillet",
"J. Maleville",
"O. Brandt",
"D. Abeck",
"R. Gianotti",
"W. Burgdorf",
"J.S. Bjorge Nelson",
"M. Seabury Stone",
"D. Bessis",
"I. Lamaury",
"O. Jonquet",
"A.S. Lycia",
"M. Seabury Stone",
"N. Prose",
"W. Tope",
"S. Miller",
"H. Kamino",
"C. Brouillard",
"P. Guyot Caquelin",
"F. Truchetet",
"L. Misery",
"A. Tran",
"M.C. Legrand",
"C. Payan",
"M. Ban",
"Y. Ichiki",
"Y. Kitajima",
"B. Guillot",
"H. Chraibi",
"C. Girard",
"O. Dereure",
"M. Lalande",
"D. Bessis",
"J.D. Cherry",
"D. Coustou",
"C. leaute-labreze",
"B. Bioulac-Sage",
"R. Gutzmer",
"R.A. Herbst",
"P. Kiehl",
"A. Taïeb",
"F. Megraud",
"V. Legrain",
"P. Mortureux",
"J. Maleville",
"H. Kosuge",
"K. Tanaka-Taya",
"H. Miyoshi",
"K. Amo",
"R. Harada",
"T. Ebihara",
"F. Drago",
"A. Rebora",
"S.B. Whitaker",
"J.J. Krupa",
"B.B. Singh",
"O. Roux",
"J.P. Lacour"
] |
https://doi.org/10.1016/j.jpp.2016.04.001
|
N/A
|
https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M
|
fr
| 0.999996
| 2.886405
| 3.933074
| 2.939413
| 3.876494
| 0.002759
| 1.006571
| -0.001448
| 3.386187
| -3.559074
| 5.365022
| 0.936162
| 0.087628
| 0.01075
| 4.688444
|
medical_knowledge
| 0.997499
|
questions
| 0.991302
| 0
| 0.999916
| 1
| 0.999991
| 1
| 0.999679
|
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